1 00:00:10,040 --> 00:00:11,148 Oh! 2 00:00:16,369 --> 00:00:19,715 We can't both shower at the same time, Lea. 3 00:00:19,739 --> 00:00:22,484 One of us would block the stream of water for the other. 4 00:00:22,508 --> 00:00:24,953 Oh, Shaun, this is not for the purpose of cleanliness. 5 00:00:24,977 --> 00:00:27,646 This is for the purpose of having sex with you. 6 00:00:29,315 --> 00:00:31,060 Oh. 7 00:00:31,084 --> 00:00:32,628 N-No. No. 8 00:00:32,652 --> 00:00:35,297 It would be inconvenient, possibly dangerous. 9 00:00:35,321 --> 00:00:37,633 Soap might get into difficult places. 10 00:00:37,657 --> 00:00:39,234 If we leaned against the shower handle, 11 00:00:39,258 --> 00:00:40,302 we could scald ourselves. 12 00:00:40,326 --> 00:00:42,771 Bottles could be disarranged. 13 00:00:42,795 --> 00:00:44,606 It was just a thought. 14 00:00:44,630 --> 00:00:46,642 It was a bad thought. 15 00:00:46,666 --> 00:00:47,743 I'm surprised. 16 00:00:47,767 --> 00:00:49,367 You're such an intelligent person. 17 00:00:50,970 --> 00:00:53,615 I'll... reset your alarm. 18 00:00:57,343 --> 00:00:59,822 It's a three-day weekend and a full moon. 19 00:00:59,846 --> 00:01:01,356 People are gonna do stupid things. 20 00:01:01,380 --> 00:01:04,326 I'm asking everyone to take an extra trauma call in the E.R. 21 00:01:04,350 --> 00:01:06,462 Make yourselves available if you're needed. 22 00:01:06,486 --> 00:01:07,941 Questions? 23 00:01:08,488 --> 00:01:10,499 How'd you get the bruise? 24 00:01:10,523 --> 00:01:11,767 First casualty of the full moon. 25 00:01:11,791 --> 00:01:13,168 I smacked my head on a cupboard door 26 00:01:13,192 --> 00:01:14,670 when I was reaching for my coffee mug. 27 00:01:14,694 --> 00:01:15,871 Any other questions? 28 00:01:15,895 --> 00:01:19,041 Why is there a Subaru in your parking space? 29 00:01:19,065 --> 00:01:20,542 Because it's my car. 30 00:01:20,566 --> 00:01:21,577 You have a car? 31 00:01:21,601 --> 00:01:23,579 You're gonna be seeing a lot of it. I sold the Ducati. 32 00:01:23,603 --> 00:01:24,580 What? No. 33 00:01:24,604 --> 00:01:25,814 It just wasn't practical. 34 00:01:25,838 --> 00:01:27,049 Is it already gone? Because... 35 00:01:27,073 --> 00:01:29,518 A guy from Craigslist snatched it up. 36 00:01:29,542 --> 00:01:32,711 Any other questions... Not dealing with the bike? 37 00:01:34,413 --> 00:01:36,258 It wasn't that much of a bruise. 38 00:01:37,383 --> 00:01:39,761 But the doctor at the ski resort told us 39 00:01:39,785 --> 00:01:41,430 I might develop a hematoma? 40 00:01:41,454 --> 00:01:44,167 It's not unusual, but it'll need to be drained. 41 00:01:44,624 --> 00:01:47,569 I see you were treated for melanoma six years ago, 42 00:01:47,593 --> 00:01:49,638 and, more recently, breast cancer. 43 00:01:49,662 --> 00:01:51,173 Hence the ski trip. 44 00:01:51,197 --> 00:01:52,951 A celebration. 45 00:01:53,399 --> 00:01:55,577 One year cancer-free. Also five years cancer-free. 46 00:01:58,237 --> 00:02:02,251 I don't suppose a long needle will be involved in this? 47 00:02:02,275 --> 00:02:04,219 Your hematoma extends pretty deep, 48 00:02:04,243 --> 00:02:05,854 so the needle will have to be long. 49 00:02:05,878 --> 00:02:07,523 But it's over quickly. 50 00:02:07,547 --> 00:02:09,525 Sorry, I have to intervene before this deal goes south. 51 00:02:09,549 --> 00:02:11,469 You don't mind if I step out? 52 00:02:13,064 --> 00:02:15,809 Would you like us to wait for your husband to come back? 53 00:02:16,240 --> 00:02:17,350 No. 54 00:02:17,823 --> 00:02:19,067 Let's go ahead. 55 00:02:22,421 --> 00:02:24,612 How do you get frostbite in San Jose? 56 00:02:24,636 --> 00:02:25,941 Cryotherapy accident. 57 00:02:25,965 --> 00:02:27,843 I stayed in the booth a little too long. 58 00:02:27,867 --> 00:02:29,945 I was going to stand outside for the full three minutes, 59 00:02:29,969 --> 00:02:31,647 - but he said... - I said, "No need." 60 00:02:31,671 --> 00:02:33,515 I'd set the stopwatch on my phone... 61 00:02:33,539 --> 00:02:36,218 After which, my thoughts immediately drifted, and... 62 00:02:36,242 --> 00:02:38,187 I came back to find him frozen in carbonite. 63 00:02:39,170 --> 00:02:41,346 You know, I'm more worried about the fever. 64 00:02:41,370 --> 00:02:43,292 Was the cryotherapy meant to treat something? 65 00:02:43,316 --> 00:02:44,626 No. Routine self-care. 66 00:02:44,650 --> 00:02:46,828 We've made life extension part of our health regime... 67 00:02:46,852 --> 00:02:49,484 Supplements, meditation, exercise. 68 00:02:49,518 --> 00:02:51,496 Three of my gaming apps have gone viral. 69 00:02:51,520 --> 00:02:54,309 I'm lucky enough to afford basically whatever I want, 70 00:02:54,333 --> 00:02:56,405 so I spend it on my health. 71 00:02:56,438 --> 00:02:59,838 No, I figure fever, must be an infection. 72 00:02:59,866 --> 00:03:02,806 Well, I know that frostbite can make you vulnerable. 73 00:03:02,830 --> 00:03:07,729 It just... It didn't seem severe enough to... 74 00:03:07,753 --> 00:03:10,549 Oh, sorry. I feel a little queasy. 75 00:03:10,710 --> 00:03:11,787 Aah! 76 00:03:11,811 --> 00:03:12,854 Wyatt. 77 00:03:12,878 --> 00:03:13,922 Ow! 78 00:03:22,255 --> 00:03:24,032 I need a medical transport team, stat. 79 00:03:24,056 --> 00:03:26,268 Perforated bowel. He needs immediate surgery. 80 00:03:27,875 --> 00:03:35,875 Synced & corrected by -robtor- www.addic7ed.com 81 00:03:35,900 --> 00:03:38,216 No. No. Why do people hate wind farms? 82 00:03:38,240 --> 00:03:40,251 Everyone thinks they're noisy. 83 00:03:40,275 --> 00:03:41,886 This could make a turbine sound as quiet 84 00:03:41,910 --> 00:03:43,388 as a page turning in a library. 85 00:03:43,412 --> 00:03:44,856 That's not worth our investing in? 86 00:03:44,880 --> 00:03:46,424 Did you even look... Hold on. 87 00:03:46,448 --> 00:03:48,292 Anything I need to know? 88 00:03:48,316 --> 00:03:49,460 Hematoma's drained. 89 00:03:49,484 --> 00:03:51,362 We're sending a sample to Pathology... routine. 90 00:03:51,386 --> 00:03:52,730 Should have it back sometime tomorrow. 91 00:03:52,754 --> 00:03:54,589 - Thank you. - Mm-hmm. 92 00:03:55,157 --> 00:03:57,635 I couldn't help overhearing a little. 93 00:03:57,659 --> 00:03:59,494 Are you a venture capitalist? 94 00:04:00,529 --> 00:04:02,740 The only people who ask me if I'm a VC 95 00:04:02,764 --> 00:04:05,433 are people who want a VC to invest in their project. 96 00:04:07,188 --> 00:04:11,235 Maybe, after we get your wife healthy again, we could talk? 97 00:04:11,306 --> 00:04:12,283 Call whenever you're ready. 98 00:04:12,307 --> 00:04:14,018 My life is listening to ideas. 99 00:04:14,042 --> 00:04:15,553 If it's good, I'll run it by my two partners. 100 00:04:15,577 --> 00:04:16,603 If it's really good, 101 00:04:16,644 --> 00:04:18,846 we'll take a 30% equity position in your company. 102 00:04:21,183 --> 00:04:22,308 Yeah. 103 00:04:22,651 --> 00:04:24,885 Yeah, you're the one who wanted us to get into clean technology. 104 00:04:27,055 --> 00:04:28,989 I think I've been asked out on a date. 105 00:04:30,931 --> 00:04:32,142 Nice. 106 00:04:32,167 --> 00:04:33,277 No, I work with him. 107 00:04:33,302 --> 00:04:35,213 - Hasn't stopped you before. - I supervise him. 108 00:04:35,238 --> 00:04:36,282 Schedules can be changed. 109 00:04:36,307 --> 00:04:37,718 He's polyamorous. 110 00:04:38,622 --> 00:04:41,245 Unless he also texted you a ring, it's just a date. 111 00:04:41,269 --> 00:04:42,803 And you need to get out more. 112 00:04:44,172 --> 00:04:45,272 So do I. 113 00:04:51,146 --> 00:04:54,026 You want to take down the splenocolic ligament. 114 00:04:54,050 --> 00:04:57,029 Just don't nick the inferior mesenteric artery. 115 00:04:57,053 --> 00:05:00,867 I feel the I.M.A. under my finger. 116 00:05:00,891 --> 00:05:02,849 Placing the stapler. 117 00:05:03,326 --> 00:05:04,934 And cutting. 118 00:05:05,727 --> 00:05:07,006 I voted "approve." 119 00:05:09,934 --> 00:05:11,611 Disapprove. 120 00:05:11,635 --> 00:05:13,446 No opinion. 121 00:05:13,470 --> 00:05:14,447 There's a poll? 122 00:05:14,471 --> 00:05:16,849 Yes... About shower sex. 123 00:05:16,873 --> 00:05:19,585 I know it's wrong to discuss shower sex at work, 124 00:05:19,609 --> 00:05:21,287 so I did a poll instead. 125 00:05:21,311 --> 00:05:22,722 Much better. 126 00:05:22,746 --> 00:05:25,124 Dr. Murphy, do you really want people knowing the details 127 00:05:25,148 --> 00:05:26,325 of your personal life? 128 00:05:26,349 --> 00:05:29,862 You don't think they took it as an abstract question? 129 00:05:29,886 --> 00:05:32,717 No. We all take it as something that happened between you and Lea. 130 00:05:32,741 --> 00:05:34,100 And that there was a fight. 131 00:05:34,124 --> 00:05:35,635 Sometime before 8:00 a.m. today, 132 00:05:35,659 --> 00:05:37,860 which was when the poll was sent out. 133 00:05:39,396 --> 00:05:41,107 You are very astute. 134 00:05:41,131 --> 00:05:44,343 I'm seeing diffuse dilation of the large bowel here. 135 00:05:44,367 --> 00:05:45,683 Is that normal? 136 00:05:46,736 --> 00:05:49,270 Some calcified lesions. 137 00:05:50,140 --> 00:05:51,617 Wall's thin, too. 138 00:05:51,641 --> 00:05:52,785 Hirschsprung's. 139 00:05:52,809 --> 00:05:54,720 I thought Hirschsprung's was a disease only babies 140 00:05:54,744 --> 00:05:55,821 and young children got. 141 00:05:55,845 --> 00:05:57,111 It is. 142 00:05:57,781 --> 00:05:58,991 But he has it. 143 00:06:06,238 --> 00:06:07,842 We treated the Hirschsprung's 144 00:06:07,885 --> 00:06:10,056 by removing the dilated part of your colon. 145 00:06:10,080 --> 00:06:11,824 It won't impact your life, 146 00:06:11,848 --> 00:06:13,492 but we would like an explanation. 147 00:06:13,516 --> 00:06:14,860 Dr. Murphy doesn't mean 148 00:06:14,884 --> 00:06:16,495 we expect you to be a diagnostician. 149 00:06:16,519 --> 00:06:17,796 It's just... 150 00:06:17,820 --> 00:06:19,565 this was kind of singular. 151 00:06:19,589 --> 00:06:21,934 So, if you have any thoughts... 152 00:06:21,958 --> 00:06:25,227 Did anyone in your family suddenly develop these symptoms? 153 00:06:28,698 --> 00:06:32,644 I did something singular to myself about six months ago. 154 00:06:32,980 --> 00:06:35,414 I modified my genetic code. 155 00:06:35,438 --> 00:06:38,183 I did a CRISPR procedure under the guidance of some researchers 156 00:06:38,207 --> 00:06:39,585 I know in China through my work. 157 00:06:39,609 --> 00:06:41,353 They put together a series of cocktails. 158 00:06:41,377 --> 00:06:45,824 They FedExed them to be, and Sophie helped me inject them 159 00:06:45,848 --> 00:06:47,126 into my bone marrow. 160 00:06:47,150 --> 00:06:48,494 Why? 161 00:06:48,518 --> 00:06:49,895 If you know anything about CRISPR, 162 00:06:49,919 --> 00:06:51,997 you know how risky it is to tinker with your genome. 163 00:06:52,021 --> 00:06:54,744 You have no idea what problems you might let loose. 164 00:06:54,768 --> 00:06:57,369 I needed to optimize my telomerase activity. 165 00:06:57,393 --> 00:06:59,004 It's the enzyme responsible for correcting 166 00:06:59,028 --> 00:07:00,038 cell replication errors... 167 00:07:00,062 --> 00:07:01,206 Essentially, the cause of aging. 168 00:07:01,230 --> 00:07:02,474 You can't stop aging 169 00:07:02,498 --> 00:07:04,576 through changing your telomerase activity. 170 00:07:04,600 --> 00:07:08,247 You might extend your life a little, but exercise... 171 00:07:08,271 --> 00:07:09,715 It does the same thing. 172 00:07:09,739 --> 00:07:10,716 Much less risky. 173 00:07:10,740 --> 00:07:12,317 Your decision makes no sense. 174 00:07:12,341 --> 00:07:15,954 Extending my life by a few years is only my short-term goal. 175 00:07:15,978 --> 00:07:18,090 Look, you know how fast medicine is moving. 176 00:07:18,114 --> 00:07:19,992 The day isn't that far away when cloning 177 00:07:20,016 --> 00:07:23,028 will make transplants as easy as switching out a light socket. 178 00:07:23,052 --> 00:07:24,830 AI will start to make breakthroughs 179 00:07:24,854 --> 00:07:26,498 that we can't predict or understand. 180 00:07:26,522 --> 00:07:29,489 Medical knowledge will rise exponentially. 181 00:07:29,513 --> 00:07:32,271 There are babies born now who could live to see it, 182 00:07:32,295 --> 00:07:34,306 could live to be 1,000 years old. 183 00:07:34,330 --> 00:07:35,941 Maybe more. Maybe forever. 184 00:07:36,294 --> 00:07:38,577 Or at least, as long as they want to. 185 00:07:38,601 --> 00:07:41,013 So, our plan is to give my CRISPR a year 186 00:07:41,037 --> 00:07:43,081 to make sure the telomerase change works, 187 00:07:43,105 --> 00:07:45,473 and then we'll do her. 188 00:07:47,210 --> 00:07:49,198 We'll aspirate a sample of your bone marrow. 189 00:07:49,222 --> 00:07:51,456 See if we can figure out what the hell you did. 190 00:07:58,800 --> 00:07:59,911 Hey. 191 00:07:59,936 --> 00:08:04,216 Um... I don't think coffee's a good idea. 192 00:08:04,460 --> 00:08:06,271 Entire civilizations rely on it. 193 00:08:06,295 --> 00:08:08,373 But I don't think you're referring to the beverage itself. 194 00:08:08,397 --> 00:08:10,209 I don't think it's a good idea for first-years 195 00:08:10,233 --> 00:08:11,543 and fourth-years to go out. 196 00:08:11,567 --> 00:08:14,513 I am bound to supervise you at some point in the future, 197 00:08:14,537 --> 00:08:17,716 and it'd get complicated trying to change dates out, 198 00:08:17,740 --> 00:08:20,652 and the fact is... 199 00:08:20,676 --> 00:08:23,622 seeing somebody you work with rarely ends happily. 200 00:08:23,646 --> 00:08:25,757 So, I appreciate you thinking of me, but I... 201 00:08:25,781 --> 00:08:27,595 Oh, you thought it was a date. 202 00:08:29,018 --> 00:08:30,762 I'm still new here, and I thought it was 203 00:08:30,786 --> 00:08:33,392 a good opportunity to get to know each other. 204 00:08:34,090 --> 00:08:36,268 Coffee's perfect because you're asking 205 00:08:36,292 --> 00:08:39,037 the least amount of commitment from another human being. 206 00:08:39,061 --> 00:08:41,106 It's not even lunch. 207 00:08:41,130 --> 00:08:43,141 If it's still a "no," it's still a "no," 208 00:08:43,165 --> 00:08:45,529 but I'll let you re-think your answer. 209 00:08:51,794 --> 00:08:53,448 _ 210 00:08:53,482 --> 00:08:55,451 _ 211 00:08:58,936 --> 00:09:01,848 He only claimed it wasn't a date to save face. 212 00:09:01,873 --> 00:09:04,385 Or maybe I just assumed. 213 00:09:04,410 --> 00:09:05,687 But why did I assume? 214 00:09:05,712 --> 00:09:07,557 I don't think I'm some kind of narcissist 215 00:09:07,582 --> 00:09:10,794 who thinks every man wants to get close to me. 216 00:09:10,819 --> 00:09:14,332 Or we both assumed it's a date because it's a date. 217 00:09:14,357 --> 00:09:16,535 This is fun. I like being your bestie. 218 00:09:16,560 --> 00:09:17,871 Slumber party? 219 00:09:23,682 --> 00:09:26,661 I made a poll to test the popularity of shower sex. 220 00:09:26,685 --> 00:09:27,829 I heard. 221 00:09:27,853 --> 00:09:29,931 I fielded some questions about that. 222 00:09:29,955 --> 00:09:34,503 "Approve" has won, but don't get too excited, Lea. 223 00:09:34,527 --> 00:09:36,938 It's only 58-38, 224 00:09:36,962 --> 00:09:39,508 with several complicated noncommittals, 225 00:09:39,532 --> 00:09:41,877 so clearly my attitude is reasonable. 226 00:09:41,901 --> 00:09:44,146 We don't have room for a... 227 00:09:44,170 --> 00:09:46,314 skier exercise thing. 228 00:09:46,338 --> 00:09:49,351 I'm only putting it together so I can take a picture 229 00:09:49,375 --> 00:09:50,685 and sell it online. 230 00:09:50,709 --> 00:09:53,011 Why do you have it if you don't want it? 231 00:09:58,818 --> 00:10:01,605 My ex sent it. 232 00:10:02,621 --> 00:10:04,466 "Ex"? 233 00:10:04,490 --> 00:10:06,318 Husband. 234 00:10:07,426 --> 00:10:09,304 I left this thing in the attic 235 00:10:09,328 --> 00:10:11,540 until I got settled somewhere with enough space. 236 00:10:11,564 --> 00:10:13,341 And okay, that was 10 years ago, 237 00:10:13,365 --> 00:10:15,010 but it's not like it was in his way. 238 00:10:18,771 --> 00:10:23,051 We got married, not for long, right out of high school. 239 00:10:23,075 --> 00:10:24,753 Literally the boy next door. 240 00:10:24,777 --> 00:10:26,855 We grew up together. People expected it. 241 00:10:26,879 --> 00:10:30,092 It... was a big mistake. 242 00:10:30,116 --> 00:10:32,160 We both realized it pretty quickly. 243 00:10:36,922 --> 00:10:39,101 Why would you even want to live forever? 244 00:10:39,125 --> 00:10:40,469 You'd be bored out of your mind. 245 00:10:41,594 --> 00:10:42,938 The person I am now 246 00:10:42,962 --> 00:10:47,318 is miles away from the person I was at 14. 247 00:10:47,700 --> 00:10:50,196 I only get more distant every year. 248 00:10:50,923 --> 00:10:54,408 You learn to understand, 249 00:10:55,273 --> 00:10:58,287 love books that you once hated, 250 00:10:59,078 --> 00:11:01,923 sometimes people you once hated. 251 00:11:01,948 --> 00:11:06,696 Music that you didn't get the point of becomes magical. 252 00:11:06,819 --> 00:11:08,670 And a thousand new doors will open. 253 00:11:08,701 --> 00:11:10,800 I look forward to the adventure. 254 00:11:11,290 --> 00:11:12,503 Ow. 255 00:11:12,527 --> 00:11:15,460 Sorry. Adventure's not always gonna be fun. 256 00:11:16,675 --> 00:11:20,221 I figure it takes 40 or 50 years 257 00:11:20,246 --> 00:11:22,758 just to get over the things your parents did. 258 00:11:22,783 --> 00:11:24,494 If only we lived long enough, 259 00:11:24,519 --> 00:11:28,499 the human race might finally have a chance to grow up. 260 00:11:34,865 --> 00:11:37,410 What size shoes do you wear? 261 00:11:37,435 --> 00:11:38,994 7 1/2. 262 00:11:40,005 --> 00:11:42,117 "Dr. Allen's Walking On Clouds Inserts." 263 00:11:42,142 --> 00:11:44,553 Putting "doctor" in the name is always good marketing strategy. 264 00:11:44,578 --> 00:11:47,257 They're designed to reduce inflammation 265 00:11:47,282 --> 00:11:49,394 that could lead to plantar fasciitis, 266 00:11:49,419 --> 00:11:52,231 calluses, arthritis, and they feel damn good. 267 00:11:52,256 --> 00:11:54,100 Does this have anything to do with our patient's 268 00:11:54,125 --> 00:11:55,336 venture capitalist husband? 269 00:11:55,361 --> 00:11:56,872 I need testimonials. 270 00:11:56,897 --> 00:11:58,364 Labs and Path for Hannah Palmer. 271 00:12:01,642 --> 00:12:04,554 Aren't we all busy enough learning how to be surgeons? 272 00:12:04,578 --> 00:12:07,179 Do you really want to divide your focus onto something trivial? 273 00:12:12,119 --> 00:12:15,354 Because wanting to make money taints the purity of medicine? 274 00:12:17,224 --> 00:12:18,902 I have five brothers. 275 00:12:18,926 --> 00:12:21,304 I've been taking care of people my whole life. 276 00:12:21,328 --> 00:12:24,841 Someone got hurt, they came to me to patch them up. 277 00:12:24,865 --> 00:12:28,144 I became a doctor so I could get paid for it, 278 00:12:28,168 --> 00:12:31,347 but also because I'm good at taking care of people. 279 00:12:31,371 --> 00:12:33,683 It's possible to do something for more than one reason. 280 00:12:45,252 --> 00:12:46,729 The news is bad. 281 00:12:55,789 --> 00:12:59,101 There's an abnormally healthy population 282 00:12:59,126 --> 00:13:02,172 of hematopoietic progenitor stem cells. 283 00:13:02,197 --> 00:13:03,308 He did it? 284 00:13:03,333 --> 00:13:04,543 It's significant. 285 00:13:04,568 --> 00:13:07,547 He's succeeded in optimizing enough telomerase activity 286 00:13:07,572 --> 00:13:10,051 to potentially add 10 years to his natural life. 287 00:13:10,076 --> 00:13:12,554 Well, assuming it doesn't subtract about 50. 288 00:13:12,579 --> 00:13:14,157 There's already an autoimmune reaction 289 00:13:14,182 --> 00:13:15,392 that mimics Hirschsprung's. 290 00:13:15,417 --> 00:13:16,739 Who knows what else he did? 291 00:13:16,764 --> 00:13:19,282 What if this is the opposite of an auto-immune condition? 292 00:13:19,307 --> 00:13:20,542 What if he's done something 293 00:13:20,567 --> 00:13:22,374 that lowers his resistance to infection? 294 00:13:22,399 --> 00:13:24,744 Then we'd be seeing more opportunistic infections 295 00:13:24,769 --> 00:13:26,275 of the lungs and skin. 296 00:13:26,299 --> 00:13:28,010 If you lived another 1,000 years, 297 00:13:28,034 --> 00:13:30,246 would you be with the same person at the end 298 00:13:30,270 --> 00:13:31,647 as at the beginning? 299 00:13:31,671 --> 00:13:32,905 - No. - No. 300 00:13:34,007 --> 00:13:35,551 No, if you assume monogamy. 301 00:13:35,575 --> 00:13:37,553 I mean, that puts too much strain on a relationship. 302 00:13:37,577 --> 00:13:39,622 Is one person supposed to be everything to another, 303 00:13:39,646 --> 00:13:41,457 all the time, for 1,000 years? 304 00:13:41,481 --> 00:13:45,164 Apparently Jesus agrees. On monogamy. 305 00:13:45,188 --> 00:13:47,596 He said that, in Heaven, there'll be no more marriages. 306 00:13:47,620 --> 00:13:51,033 I guess humans can't sustain a relationship that long. 307 00:13:51,057 --> 00:13:52,434 You read the New Testament, too? 308 00:13:52,458 --> 00:13:54,937 And the Qur'an. And other things. 309 00:13:54,961 --> 00:13:56,338 It's like you're a stalker. 310 00:13:56,362 --> 00:13:58,941 It's like you and God had an acrimonious divorce. 311 00:13:58,965 --> 00:14:02,401 What if he caused neurofibromatosis? 312 00:14:02,425 --> 00:14:04,847 Microscopic tumors forming on the nerve sheath? 313 00:14:04,871 --> 00:14:06,382 Mm. Possible, but there'd have been 314 00:14:06,406 --> 00:14:07,750 some evidence of Schwann cell growth 315 00:14:07,774 --> 00:14:08,880 around his colon. 316 00:14:08,904 --> 00:14:11,777 Would you still love your wife in 1,000 years? 317 00:14:13,613 --> 00:14:15,691 You have three answers. That should be enough. 318 00:14:15,715 --> 00:14:18,027 Park's marriage failed in far less time, 319 00:14:18,051 --> 00:14:19,628 and Enrique doesn't even try. 320 00:14:19,652 --> 00:14:21,263 Asher is an... 321 00:14:21,287 --> 00:14:22,731 unknown quantity. 322 00:14:22,755 --> 00:14:24,057 You're committed. 323 00:14:24,081 --> 00:14:25,724 You've made promises. 324 00:14:28,127 --> 00:14:30,172 I've made promises based on 325 00:14:30,196 --> 00:14:33,252 an understood human life-span, Murphy. 326 00:14:34,033 --> 00:14:37,112 Most likely diagnosis is autoimmune polyneuropathy. 327 00:14:37,136 --> 00:14:38,814 It damaged the enteral ganglion nerve 328 00:14:38,838 --> 00:14:40,129 and led to the perforations. 329 00:14:40,163 --> 00:14:42,511 Start him on steroids and immunosuppressants. 330 00:14:42,974 --> 00:14:44,352 Dr. Andrews. 331 00:14:44,377 --> 00:14:46,255 So, you wouldn't have gotten married 332 00:14:46,280 --> 00:14:48,057 if you thought it would be forever. 333 00:14:48,082 --> 00:14:50,828 You expect all relationships to fail over time. 334 00:14:50,853 --> 00:14:52,620 It's just a question of how long? 335 00:14:54,513 --> 00:14:56,233 I love her now. 336 00:14:56,756 --> 00:15:00,279 I intend to love her as long as I live. 337 00:15:01,134 --> 00:15:05,881 But, eventually, everything breaks. 338 00:15:14,583 --> 00:15:15,893 I always go back to comfort reading 339 00:15:15,918 --> 00:15:17,068 when I'm in the hospital. 340 00:15:17,098 --> 00:15:18,933 Cozy mysteries in little English villages, 341 00:15:18,958 --> 00:15:21,425 where nothing bad happens to anyone we like. 342 00:15:23,242 --> 00:15:25,153 We've gotten your results back. 343 00:15:25,178 --> 00:15:26,222 When will your husband be... 344 00:15:26,247 --> 00:15:27,480 Is it cancer? 345 00:15:29,989 --> 00:15:31,156 Yes. 346 00:15:33,219 --> 00:15:34,938 Thyroid carcinoma. 347 00:15:35,707 --> 00:15:37,585 We're gonna do a complete imaging series 348 00:15:37,610 --> 00:15:38,788 to pinpoint just how advanced... 349 00:15:38,813 --> 00:15:40,235 Treatment? 350 00:15:40,847 --> 00:15:44,159 Surgery to remove some or all of your thyroid 351 00:15:44,184 --> 00:15:46,563 is usually the first line of defense. 352 00:15:46,588 --> 00:15:49,166 Sometimes, we can wait, but given the hematoma 353 00:15:49,191 --> 00:15:53,338 was probably caused by the tumor invading nearby vasculatures, 354 00:15:53,363 --> 00:15:55,775 we should probably do it in the next few days. 355 00:15:55,800 --> 00:15:59,046 Later, there'll be radioactive iodine treatment... 356 00:16:00,740 --> 00:16:02,084 Panic attack? 357 00:16:07,860 --> 00:16:09,170 Her trachea's deviated to the right. 358 00:16:09,195 --> 00:16:11,607 The tumor's compressing it. We're doing surgery now. 359 00:16:22,580 --> 00:16:24,158 What happened? The nurse just said "surgery." 360 00:16:24,182 --> 00:16:25,781 Was it the hematoma? 361 00:16:26,864 --> 00:16:28,265 It's more serious. 362 00:16:29,954 --> 00:16:32,466 I-It's not cancer... 363 00:16:32,490 --> 00:16:34,135 again. 364 00:16:34,159 --> 00:16:36,333 Thyroid carcinoma. 365 00:16:36,961 --> 00:16:39,907 We've removed her thyroid. She's doing well. 366 00:16:39,931 --> 00:16:41,709 We're looking into potential causes... 367 00:16:41,733 --> 00:16:43,544 Genetic, environmental. 368 00:16:43,568 --> 00:16:47,678 There may be a deeper issue that we can find and address. 369 00:16:57,982 --> 00:16:59,690 I can't do this. 370 00:17:01,653 --> 00:17:03,694 You've done it before. 371 00:17:04,389 --> 00:17:06,113 You'll do it this time. 372 00:17:11,830 --> 00:17:13,579 Do you know what it's like... 373 00:17:14,466 --> 00:17:16,077 to wake up every morning and know your wife 374 00:17:16,101 --> 00:17:17,749 might not be here next year? 375 00:17:19,704 --> 00:17:22,850 All those treatments... 376 00:17:22,874 --> 00:17:26,320 they all... they all have this little tag attached to them 377 00:17:26,344 --> 00:17:29,757 that says, "Because she might die." 378 00:17:29,781 --> 00:17:33,360 And you see them put those gloves on 379 00:17:33,384 --> 00:17:34,595 before they hook up the chemo. 380 00:17:34,619 --> 00:17:36,059 You know why they do that. 381 00:17:37,489 --> 00:17:39,356 It's because it's poison. 382 00:17:41,626 --> 00:17:43,317 And you sit there... 383 00:17:44,462 --> 00:17:47,988 and you watch them shove poison into the person you love. 384 00:17:48,299 --> 00:17:49,907 And why? 385 00:17:51,302 --> 00:17:53,604 Because she might die. 386 00:17:55,974 --> 00:17:58,675 We're killing her because she might die. 387 00:18:03,414 --> 00:18:04,692 Go for a run. 388 00:18:05,088 --> 00:18:07,049 Go punch a wall. 389 00:18:07,452 --> 00:18:08,993 You need to release some endorphins. 390 00:18:09,017 --> 00:18:11,065 My release is my job. 391 00:18:11,089 --> 00:18:12,800 That's why I love it. 392 00:18:12,824 --> 00:18:15,669 My work requires total focus. 393 00:18:15,693 --> 00:18:16,971 And every minute I'm working 394 00:18:16,995 --> 00:18:19,269 is a minute I'm not thinking about... 395 00:18:19,864 --> 00:18:20,998 losing her. 396 00:18:26,602 --> 00:18:28,048 I have to go. 397 00:18:33,727 --> 00:18:36,938 Your pain and weakness are consistent with polyneuropathy, 398 00:18:36,962 --> 00:18:39,693 treatable with steroids and immunosuppressants. 399 00:18:39,717 --> 00:18:42,920 If you live 1,000 years, will you still love Sophie? 400 00:18:45,375 --> 00:18:46,519 Yes. 401 00:18:46,544 --> 00:18:48,355 How can you be sure? 402 00:18:48,380 --> 00:18:51,026 People change. You expect to change. 403 00:18:51,385 --> 00:18:54,475 Sophie and I will change together. 404 00:18:54,499 --> 00:18:55,709 We'll go through the same adventures 405 00:18:55,733 --> 00:18:56,811 and learn the same lessons. 406 00:18:56,835 --> 00:18:59,108 What if you go through the same adventures 407 00:18:59,137 --> 00:19:01,015 and learn different lessons? 408 00:19:01,039 --> 00:19:04,084 Even if we did, whoever, whatever we become, 409 00:19:04,108 --> 00:19:05,786 Sophie will always be beautiful. 410 00:19:05,810 --> 00:19:08,362 I mean, she could turn into a machine or a set of pixels 411 00:19:08,386 --> 00:19:11,225 or a giant purple flower, and she'll still be beautiful, 412 00:19:11,249 --> 00:19:14,451 because it's part of her essential nature. 413 00:19:17,502 --> 00:19:19,913 But if you don't know how you'll change, 414 00:19:19,938 --> 00:19:21,750 you don't know how you'll change. 415 00:19:21,775 --> 00:19:23,208 Shaun. 416 00:19:24,421 --> 00:19:25,799 We'll let you get some rest. 417 00:19:25,824 --> 00:19:27,775 The steroids should make you feel a lot better. 418 00:19:34,105 --> 00:19:38,390 Why didn't you ever mention you had an ex-husband? 419 00:19:39,203 --> 00:19:43,216 Shaun, I've barely thought about him in years. 420 00:19:43,241 --> 00:19:47,221 I didn't mention him because he's not important. 421 00:19:47,246 --> 00:19:50,225 I know. That's the problem. 422 00:19:50,314 --> 00:19:53,360 At one time, you felt he was important enough to your life 423 00:19:53,385 --> 00:19:57,065 to marry him, and now you barely think of him. 424 00:19:57,090 --> 00:20:00,736 You make long-term plans, you have expectations, 425 00:20:00,761 --> 00:20:02,472 and then something happens to you, 426 00:20:02,497 --> 00:20:05,334 and suddenly you're a different person. 427 00:20:06,871 --> 00:20:11,256 I know you don't like change, but it's not all bad. 428 00:20:11,955 --> 00:20:16,336 After all, you are working to change yourself all the time. 429 00:20:16,361 --> 00:20:22,476 I'm working to be a better surgeon, a better boyfriend, 430 00:20:22,501 --> 00:20:24,766 better at the things I've chosen, 431 00:20:24,794 --> 00:20:26,188 but this... 432 00:20:26,656 --> 00:20:28,201 other change... It's unpredictable. 433 00:20:28,226 --> 00:20:29,236 You don't choose it. 434 00:20:29,261 --> 00:20:30,984 It just comes at you. 435 00:20:31,696 --> 00:20:34,082 Oh, it's like hurricanes before 1873, 436 00:20:34,118 --> 00:20:36,178 when the Army Signal Corps first put up flags 437 00:20:36,215 --> 00:20:38,078 to warn people storms were coming. 438 00:20:38,102 --> 00:20:40,814 Before that, houses were flattened, lives destroyed, 439 00:20:40,838 --> 00:20:42,973 and there was no way to see it was heading for you. 440 00:20:42,997 --> 00:20:44,211 Shaun. 441 00:20:45,222 --> 00:20:48,968 Our relationship will not end in natural disaster. 442 00:20:48,993 --> 00:20:50,537 It did begin in one. 443 00:20:52,899 --> 00:20:56,011 I'm going to look in on my patient. 444 00:20:56,468 --> 00:20:58,198 Okay. 445 00:21:04,531 --> 00:21:08,077 Blood and saliva will tell us if there's a genetic cause, 446 00:21:08,101 --> 00:21:09,913 and the samples we take from your house 447 00:21:09,937 --> 00:21:11,938 will tell us if there's something environmental. 448 00:21:13,874 --> 00:21:16,697 I know it's s-stupid. 449 00:21:17,477 --> 00:21:20,056 I've almost felt guilty for my cancer, 450 00:21:20,080 --> 00:21:24,483 like I arbitrarily decided to be sick and burdensome. 451 00:21:26,954 --> 00:21:28,431 Do the people you're close to 452 00:21:28,455 --> 00:21:31,267 ever act like you're a burden to them? 453 00:21:31,291 --> 00:21:32,458 You mean Alan. 454 00:21:34,761 --> 00:21:36,673 He's scared. 455 00:21:36,697 --> 00:21:41,010 He takes the exit he's got and he turns to his work. 456 00:21:41,034 --> 00:21:42,845 You're okay with that? 457 00:21:50,410 --> 00:21:52,822 I accept this compromise. 458 00:21:52,846 --> 00:21:55,126 That's not the hard part. The hard part is... 459 00:21:56,016 --> 00:21:57,612 not knowing. 460 00:21:59,060 --> 00:22:02,576 Each new thing that happens, I worry, "Is this it? 461 00:22:03,857 --> 00:22:05,746 Is this where I lose him? 462 00:22:06,953 --> 00:22:08,831 Is this where he breaks?" 463 00:22:15,797 --> 00:22:18,309 So, this is boiled coffee. 464 00:22:18,334 --> 00:22:20,078 Some people call it "Turkish coffee," 465 00:22:20,240 --> 00:22:23,179 or "Greek coffee," or "Egyptian coffee"... 466 00:22:23,229 --> 00:22:24,479 Because we need to take ownership 467 00:22:24,518 --> 00:22:26,082 and put things in categories. 468 00:22:26,112 --> 00:22:27,434 Yeah. 469 00:22:27,887 --> 00:22:29,431 You actually live in this thing, 470 00:22:29,456 --> 00:22:31,668 in the hospital parking garage? 471 00:22:31,693 --> 00:22:32,870 Why not? 472 00:22:32,895 --> 00:22:34,139 Convenient for work. 473 00:22:34,164 --> 00:22:36,609 When I want to spend a few days off the beaten track, 474 00:22:36,634 --> 00:22:38,361 it's convenient for that, too. 475 00:22:38,859 --> 00:22:41,604 Ooh. I'm gonna get three sips in this. 476 00:22:41,629 --> 00:22:43,630 But three really great sips. 477 00:22:45,372 --> 00:22:47,317 That's how I try to live my life... 478 00:22:47,342 --> 00:22:51,578 Try to appreciate, savor, not pass by. 479 00:22:54,621 --> 00:22:56,671 Is that what the polyamory is about? 480 00:22:57,851 --> 00:23:00,663 Does it really work, or is it one of those theories about life 481 00:23:00,688 --> 00:23:02,499 that people regret later? 482 00:23:02,524 --> 00:23:03,701 No regrets so far. 483 00:23:03,726 --> 00:23:05,304 Mm-hmm. No, I guess not. 484 00:23:05,329 --> 00:23:07,766 Not while you're young and having fun. 485 00:23:08,643 --> 00:23:09,953 It is fun, 486 00:23:09,978 --> 00:23:11,756 but not for the reasons that you're thinking. 487 00:23:11,781 --> 00:23:13,313 It isn't about sex. 488 00:23:13,968 --> 00:23:16,880 It's about commitment, emotional connection. 489 00:23:16,905 --> 00:23:19,250 The joy I'm sure you get out of a relationship, 490 00:23:19,275 --> 00:23:20,252 I get a little more. 491 00:23:20,277 --> 00:23:22,389 Also, I have to give a little more. 492 00:23:22,509 --> 00:23:24,241 But that's meaningful, too. 493 00:23:25,272 --> 00:23:26,868 Hmm. 494 00:23:27,714 --> 00:23:29,275 Do you mind if I ask you something, 495 00:23:29,343 --> 00:23:31,217 since we're getting personal? 496 00:23:34,982 --> 00:23:36,459 Sure. 497 00:23:36,783 --> 00:23:39,218 What's your favorite misheard song lyric? 498 00:23:47,554 --> 00:23:48,987 This is nice. 499 00:23:50,977 --> 00:23:53,061 I'm glad it's not a date. 500 00:23:53,467 --> 00:23:54,977 Me, too. 501 00:23:55,002 --> 00:23:56,770 I don't believe in those categories. 502 00:24:01,221 --> 00:24:03,833 He reported widespread bilateral pain, 503 00:24:03,858 --> 00:24:04,835 then he keeled over. 504 00:24:04,860 --> 00:24:06,204 B.P. dropped to 80 over palp. 505 00:24:06,229 --> 00:24:07,340 I'll order a vasopressor. 506 00:24:07,365 --> 00:24:08,776 - Already did. - Good. 507 00:24:08,801 --> 00:24:12,714 We need an EKG, CBC, and chest images, and a new diagnosis. 508 00:24:12,739 --> 00:24:15,518 Whatever he caused with CRISPR, it's not just neuropathy. 509 00:24:15,543 --> 00:24:17,487 Something else is killing him. 510 00:24:23,544 --> 00:24:25,198 What if he's caused something that mimics 511 00:24:25,238 --> 00:24:27,274 carcinomatous autonomic neuropathy? 512 00:24:27,298 --> 00:24:29,673 It explains the B.P. and bowel issue. 513 00:24:29,911 --> 00:24:32,879 That doesn't explain the sensory issue that led to the frostbite. 514 00:24:36,071 --> 00:24:37,682 A connective tissue disorder? 515 00:24:37,706 --> 00:24:39,083 That would have shown up on the scans. 516 00:24:39,107 --> 00:24:40,621 His chest looks normal. 517 00:24:45,647 --> 00:24:48,259 Maybe we can't think of the answer because there is no answer. 518 00:24:48,283 --> 00:24:50,361 We keep trying to jam it into these categories we know, 519 00:24:50,385 --> 00:24:51,858 the diseases that we know. 520 00:24:51,882 --> 00:24:54,232 But this never existed before. 521 00:24:54,256 --> 00:24:56,200 He created a new combination of genetic code. 522 00:24:56,224 --> 00:24:58,069 That means a new combination of symptoms. 523 00:24:58,093 --> 00:25:00,304 So, we shouldn't be looking at what fits the picture, 524 00:25:00,328 --> 00:25:02,006 but at what's closest to the picture, 525 00:25:02,030 --> 00:25:03,874 so we can at least figure out a treatment. 526 00:25:03,898 --> 00:25:07,745 And what it's closest to is amyloidosis. 527 00:25:07,769 --> 00:25:10,381 This isn't an autoimmune neuropathy, 528 00:25:10,405 --> 00:25:12,783 so the nerves must be under attack by something else. 529 00:25:12,807 --> 00:25:14,885 Something like amyloid disease could leave deposits 530 00:25:14,909 --> 00:25:17,622 along the nerves, causing the symptoms we've seen. 531 00:25:17,646 --> 00:25:19,557 Where do we look for those deposits? 532 00:25:19,581 --> 00:25:21,592 The spleen. 533 00:25:27,689 --> 00:25:29,233 Drink all 8 ounces. 534 00:25:30,133 --> 00:25:32,303 We talked. We had a few laughs. 535 00:25:32,327 --> 00:25:34,138 Well, sounds date-y to me. 536 00:25:35,230 --> 00:25:36,974 I don't think Enrique's a player. 537 00:25:36,998 --> 00:25:38,509 No, he's kind of the opposite of a player. 538 00:25:38,533 --> 00:25:41,012 With him, emotional connection is the point. 539 00:25:41,036 --> 00:25:43,247 He's trying to live some idealistic fantasy 540 00:25:43,271 --> 00:25:45,216 where everyone is nice and no one is jealous. 541 00:25:45,240 --> 00:25:46,784 I am so staying away. 542 00:25:46,808 --> 00:25:47,985 Well, of course. 543 00:25:48,009 --> 00:25:49,186 Once I heard "emotional connection," 544 00:25:49,210 --> 00:25:50,955 I knew the game was over. 545 00:25:50,979 --> 00:25:52,323 What does that mean? 546 00:25:52,347 --> 00:25:54,058 I'm against emotion? 547 00:25:54,082 --> 00:25:56,227 I'm not the one with "cold-hearted bitch" 548 00:25:56,251 --> 00:25:57,928 as my social media hashtag. 549 00:25:57,952 --> 00:25:59,130 She's an excellent doctor. 550 00:25:59,154 --> 00:26:00,598 Every time you've loved somebody, 551 00:26:00,622 --> 00:26:02,566 it's ended in disappointment or death... 552 00:26:02,590 --> 00:26:03,668 Sometimes both. 553 00:26:03,692 --> 00:26:05,002 It's like a reflex now. 554 00:26:05,026 --> 00:26:08,105 You just expect that everything ends badly, so why start? 555 00:26:08,129 --> 00:26:11,542 So, despite the many practical reasons not to go out 556 00:26:11,566 --> 00:26:13,544 with a first-year, this is all about me? 557 00:26:13,568 --> 00:26:16,079 Is that a diamond ring? 558 00:26:17,272 --> 00:26:18,449 I mean, it's pretty. 559 00:26:18,473 --> 00:26:20,084 Our patient caught her fiancé cheating. 560 00:26:20,108 --> 00:26:22,186 Big fight. He demanded the ring back. 561 00:26:22,210 --> 00:26:23,587 She swallowed it. 562 00:26:23,611 --> 00:26:24,789 I did. 563 00:26:24,813 --> 00:26:27,391 You don't even know if this is "going out," and that's the point. 564 00:26:27,415 --> 00:26:29,360 It doesn't matter what Enrique's offering. 565 00:26:29,384 --> 00:26:31,729 Whether it's friendship or romance, you're not investing. 566 00:26:31,753 --> 00:26:32,963 You're risk-averse. 567 00:26:32,987 --> 00:26:34,131 Your portfolio right now 568 00:26:34,155 --> 00:26:36,200 is entirely in T-Bills and money market. 569 00:26:36,224 --> 00:26:37,468 I have no idea what that means. 570 00:26:37,492 --> 00:26:39,170 And it's too bad, because a guy that can make you laugh 571 00:26:39,194 --> 00:26:41,138 might be just what you need right now. 572 00:26:41,623 --> 00:26:43,541 It's progressed to your large intestine. 573 00:26:43,565 --> 00:26:45,943 Here's a plastic bag. Put it over the toilet seat. 574 00:26:45,967 --> 00:26:48,179 You'll have every opportunity to recover your property. 575 00:26:52,059 --> 00:26:54,826 Don't run away from a chance at love. 576 00:26:56,202 --> 00:26:58,121 It's a date... 577 00:26:58,780 --> 00:27:00,791 maybe. I don't know. 578 00:27:00,815 --> 00:27:01,982 Oh. 579 00:27:03,618 --> 00:27:05,529 Her house is full of T.C.E... 580 00:27:05,553 --> 00:27:06,764 A side effect from chip-making 581 00:27:06,788 --> 00:27:08,666 back in Silicon Valley's early days. 582 00:27:08,690 --> 00:27:10,634 So, they move away from their toxic home, 583 00:27:10,658 --> 00:27:12,103 and hopefully things get a little better. 584 00:27:12,127 --> 00:27:13,404 Probably not much. 585 00:27:13,428 --> 00:27:15,406 She also has a genetic predisposition. 586 00:27:15,430 --> 00:27:17,241 It's both? 587 00:27:17,265 --> 00:27:19,066 She shouldn't go outside in a rainstorm. 588 00:27:20,426 --> 00:27:22,446 How do you tell a woman that her third cancer 589 00:27:22,470 --> 00:27:24,271 likely won't be close to her last? 590 00:27:27,375 --> 00:27:29,943 Unfortunately, this is a teaching moment. 591 00:27:32,747 --> 00:27:35,326 Dr. Allen, after 12 hours on duty, 592 00:27:35,350 --> 00:27:38,028 I can report that your inserts came through. 593 00:27:38,052 --> 00:27:40,309 Check your e-mail. You'll find my testimonial. 594 00:27:41,369 --> 00:27:42,500 Claire. Olivia. 595 00:27:50,198 --> 00:27:53,134 And if you're right, what will you do? 596 00:27:53,435 --> 00:27:56,046 We'll treat the symptoms with targeted drug therapies. 597 00:27:56,070 --> 00:27:58,589 There really isn't a disease, as such, that we can address. 598 00:27:58,631 --> 00:28:00,007 Ow. 599 00:28:05,951 --> 00:28:06,995 The pain shifted? 600 00:28:07,019 --> 00:28:08,129 Yeah. 601 00:28:08,153 --> 00:28:09,330 Oh. 602 00:28:09,354 --> 00:28:10,632 Never mind about the ultrasound. 603 00:28:10,656 --> 00:28:12,033 It'll be easier to check for deposits 604 00:28:12,057 --> 00:28:13,101 after the organ's been removed. 605 00:28:13,125 --> 00:28:14,435 After it's... Yeah. 606 00:28:14,459 --> 00:28:16,294 His spleen's about to rupture. Call a transport team. 607 00:28:27,603 --> 00:28:30,648 It's called Li-Fraumeni Syndrome... LFS. 608 00:28:30,672 --> 00:28:32,383 An inherited predisposition 609 00:28:32,407 --> 00:28:35,119 to developing a wide range of cancers. 610 00:28:35,143 --> 00:28:37,088 Yes, there was a toxin in your environment 611 00:28:37,112 --> 00:28:38,756 that likely played a role in this, 612 00:28:38,780 --> 00:28:40,992 but there will be other triggers in the future. 613 00:28:41,808 --> 00:28:43,194 Your body is super sensitive 614 00:28:43,218 --> 00:28:45,886 and will respond with tumors for the rest of your life. 615 00:28:53,194 --> 00:28:55,906 I know that's a shock, 616 00:28:55,930 --> 00:28:58,409 but here's what you should know... 617 00:28:58,433 --> 00:29:02,102 Most cancers are treatable if found early enough. 618 00:29:05,440 --> 00:29:08,352 We know the most common associated with LFS, 619 00:29:08,376 --> 00:29:10,554 and we can do surveillance... 620 00:29:10,578 --> 00:29:14,048 Nip anything in the bud before it becomes a problem. 621 00:29:15,583 --> 00:29:19,830 It may not seem this way now, but this is good. 622 00:29:19,854 --> 00:29:21,866 We know what we're dealing with. 623 00:29:21,890 --> 00:29:24,902 We're warned, and we'll be ready. 624 00:29:32,667 --> 00:29:34,912 He won't be able to handle this. 625 00:29:39,641 --> 00:29:42,620 Liver, pancreas... Other organs look normal. 626 00:29:42,644 --> 00:29:43,954 Ah. 627 00:29:43,978 --> 00:29:47,058 But there are calcified lesions along these nerves. 628 00:29:47,082 --> 00:29:49,160 He's gonna be in pain like this for the rest of his life. 629 00:29:49,184 --> 00:29:52,463 No. There's a reasonable chance it'll get worse 630 00:29:52,487 --> 00:29:53,864 as time goes on. 631 00:29:53,888 --> 00:29:55,933 I need my sharp-blunt curved scissors. 632 00:29:55,957 --> 00:29:58,292 What if we used CRISPR to reverse CRISPR? 633 00:29:59,828 --> 00:30:02,673 Researchers have identified a protein in certain bacteria 634 00:30:02,697 --> 00:30:04,642 that inhibits CRISPR. 635 00:30:04,666 --> 00:30:07,044 What if we insert the DNA that makes that protein 636 00:30:07,068 --> 00:30:08,379 into our patient's genome? 637 00:30:08,403 --> 00:30:10,348 That would deactivate the CRISPR gene. 638 00:30:10,372 --> 00:30:11,716 So, CRISPR messed him up permanently, 639 00:30:11,740 --> 00:30:13,451 and you think we should do more of it? 640 00:30:13,475 --> 00:30:15,252 I don't know. Our patient is a risk-taker. 641 00:30:15,276 --> 00:30:16,921 We'd need a delivery mechanism. 642 00:30:16,945 --> 00:30:19,223 The code would have to be introduced through a virus... 643 00:30:19,247 --> 00:30:22,282 A virus that specifically targets nerves. 644 00:30:24,018 --> 00:30:25,696 Polio targets nerves. 645 00:30:25,720 --> 00:30:27,665 Because this isn't risky enough. 646 00:30:27,689 --> 00:30:29,133 Polio is such a dangerous virus 647 00:30:29,157 --> 00:30:31,569 because it's so good at penetrating the nervous system. 648 00:30:49,611 --> 00:30:50,955 Dr. Murphy? 649 00:30:55,016 --> 00:31:00,030 She's going to be this way... forever. 650 00:31:00,054 --> 00:31:03,033 She'll have good periods and bad periods. 651 00:31:03,057 --> 00:31:06,286 But she will always have to be on her guard. 652 00:31:06,761 --> 00:31:10,373 Is she always gonna have to be on guard against you, too? 653 00:31:11,071 --> 00:31:12,282 What does that mean? 654 00:31:12,307 --> 00:31:14,585 Chronic illness puts strain on relationships. 655 00:31:14,736 --> 00:31:18,416 Statistically, it is more often the man who can't handle it. 656 00:31:18,440 --> 00:31:20,718 Our marriage is none of your business. 657 00:31:20,742 --> 00:31:22,252 Her health is my business. 658 00:31:22,277 --> 00:31:24,328 And your behavior adds to her stress. 659 00:31:26,714 --> 00:31:30,995 You look at her, and you imagine she's gone, and that is hard. 660 00:31:31,019 --> 00:31:32,252 I get it. 661 00:31:34,322 --> 00:31:37,275 She thinks the same thing when she looks at you. 662 00:31:38,026 --> 00:31:40,646 I never complain to her. I know it's nobody's fault. 663 00:31:40,670 --> 00:31:43,607 You don't think she knows you have trouble with all this? 664 00:31:43,631 --> 00:31:46,076 Every time something new happens, 665 00:31:46,100 --> 00:31:48,913 she wonders, is this the straw 666 00:31:48,937 --> 00:31:51,539 that is gonna break your marriage? 667 00:31:52,379 --> 00:31:54,924 You've got her living in a constant state of uncertainty. 668 00:31:54,949 --> 00:31:57,837 That is practically the definition of stress. 669 00:31:59,130 --> 00:32:02,927 So, this is the "straighten up and fly right" lecture. 670 00:32:02,951 --> 00:32:04,084 No. 671 00:32:06,054 --> 00:32:08,014 I am... 672 00:32:08,857 --> 00:32:13,894 I'm telling you to consider how best to time your divorce. 673 00:32:15,263 --> 00:32:18,175 There are gonna be a lot of new issues dropping on Hannah, 674 00:32:18,199 --> 00:32:19,720 and if you're gonna end up leaving anyway, 675 00:32:19,761 --> 00:32:21,093 you should start planning now. 676 00:32:21,129 --> 00:32:22,419 I don't want to leave my wife. 677 00:32:22,444 --> 00:32:24,072 My best advice? 678 00:32:25,112 --> 00:32:28,868 Help her through this next round of treatment as best you can, 679 00:32:29,383 --> 00:32:31,245 and then get out. 680 00:32:32,173 --> 00:32:35,619 It's hard living with someone who needs so much. 681 00:32:35,644 --> 00:32:39,624 I know you feel there is a point where you have nothing left, 682 00:32:39,649 --> 00:32:41,422 where you're ready to break. 683 00:32:43,003 --> 00:32:48,041 Just... don't break when she needs you most. 684 00:32:49,250 --> 00:32:51,328 Get out before that happens. 685 00:33:11,543 --> 00:33:13,788 Reading an article that's five years old? 686 00:33:13,812 --> 00:33:16,625 Dr. Glassman was once involved in an experimental attempt 687 00:33:16,649 --> 00:33:19,594 to treat Parkinson's with CRISPR technology. 688 00:33:19,618 --> 00:33:20,695 It failed. 689 00:33:20,719 --> 00:33:22,564 So, it's both old and it didn't work? 690 00:33:22,588 --> 00:33:25,233 Dr. Glassman likes his failures to be informative. 691 00:33:25,257 --> 00:33:27,268 That's why his articles are longer. 692 00:33:27,292 --> 00:33:29,887 Do you worry about losing the people you love? 693 00:33:35,601 --> 00:33:38,346 Because we can't stop ourselves from changing, 694 00:33:38,370 --> 00:33:40,682 which means we might stop loving someone, 695 00:33:40,706 --> 00:33:42,217 or they might stop loving us. 696 00:33:42,241 --> 00:33:44,235 It is a very bad thing. 697 00:33:44,861 --> 00:33:46,287 It is. 698 00:33:49,348 --> 00:33:53,662 So, no one can ever feel... safe. 699 00:33:53,686 --> 00:33:57,655 How can you keep going if you never feel safe? 700 00:34:02,061 --> 00:34:04,829 Well, sometimes, not changing is just as dangerous. 701 00:34:07,700 --> 00:34:11,345 So, how do you know when to do what? 702 00:34:13,806 --> 00:34:16,051 If you find the answer to that, let me know. 703 00:34:22,514 --> 00:34:24,325 - I have it. - You do? 704 00:34:24,349 --> 00:34:27,262 Dr. Glassman used varicella zoster virus 705 00:34:27,286 --> 00:34:30,098 as the delivery mechanism, which didn't work. 706 00:34:30,122 --> 00:34:32,200 His first choice was herpes simplex, 707 00:34:32,224 --> 00:34:33,868 but the technology was not up 708 00:34:33,892 --> 00:34:35,670 to putting their DNA package into it. 709 00:34:36,142 --> 00:34:38,073 The technology has improved. 710 00:34:38,097 --> 00:34:39,464 It can be done. 711 00:34:45,771 --> 00:34:47,415 Using conventional treatments, 712 00:34:47,439 --> 00:34:49,084 there's nothing more we can do for you. 713 00:34:49,108 --> 00:34:51,976 The pain will be permanent, and it could get worse. 714 00:34:53,345 --> 00:34:57,225 Well, I've not been one to be limited by the conventional. 715 00:34:58,149 --> 00:35:00,079 We think we can reverse the CRISPR. 716 00:35:00,104 --> 00:35:03,131 You want to reverse what I did? My telomerase change? 717 00:35:03,156 --> 00:35:04,701 They want to stop your pain. 718 00:35:04,726 --> 00:35:06,637 Soph, it's temporary. 719 00:35:06,662 --> 00:35:07,999 What is it, 40 years? 720 00:35:08,037 --> 00:35:11,077 That's nothing. Our real lives are ahead of us. 721 00:35:11,102 --> 00:35:13,447 Hey, look, as long as this doesn't kill me, 722 00:35:13,472 --> 00:35:16,718 I've made the right choice, no matter how bad things get. 723 00:35:16,743 --> 00:35:17,787 No. 724 00:35:19,664 --> 00:35:24,201 I was willing to exercise for hours and fast, 725 00:35:24,225 --> 00:35:26,558 to give up all sugar and alcohol 726 00:35:26,585 --> 00:35:29,324 and do all the other things that we needed to do 727 00:35:29,348 --> 00:35:33,219 to get to a future that I knew might never come. 728 00:35:34,326 --> 00:35:38,099 But now, you're asking me to watch you suffer 729 00:35:38,504 --> 00:35:40,315 for the rest of your life. 730 00:35:49,134 --> 00:35:52,280 You're the one who embraces change. 731 00:35:53,445 --> 00:35:58,960 So, change to the person who can be happy with me... 732 00:35:59,278 --> 00:36:01,046 here and now. 733 00:36:09,822 --> 00:36:12,256 Doctors, would you mind waiting outside? 734 00:36:18,703 --> 00:36:21,142 Why did she want us to leave? 735 00:36:21,874 --> 00:36:23,819 I think she's delivering an ultimatum. 736 00:36:36,993 --> 00:36:38,604 Are you sure about this? 737 00:36:38,629 --> 00:36:41,341 It seems there's always something else 738 00:36:41,366 --> 00:36:42,967 that I have to give up. 739 00:36:45,691 --> 00:36:48,518 But this isn't like sugar or cigarettes. 740 00:36:48,542 --> 00:36:50,796 You won't get over this in a hurry. 741 00:36:51,242 --> 00:36:52,757 No. 742 00:36:53,532 --> 00:36:55,133 Not in 1,000 years. 743 00:37:05,010 --> 00:37:06,771 Are you gonna be okay? 744 00:37:07,032 --> 00:37:08,209 I'm fine. 745 00:37:08,234 --> 00:37:11,280 Alan's at work, but there should be a taxi waiting. 746 00:37:11,305 --> 00:37:14,017 I won't say goodbye, Dr. Browne, 747 00:37:14,042 --> 00:37:17,655 'cause I'll probably be seeing you again pretty soon. 748 00:37:20,417 --> 00:37:23,263 I sent your cab away. 749 00:37:23,288 --> 00:37:25,581 I'm sorry I wasn't here sooner. 750 00:37:25,911 --> 00:37:29,558 I had to present a proposal to my partners. 751 00:37:37,126 --> 00:37:38,871 I'm selling them my share of the business. 752 00:37:43,181 --> 00:37:45,593 Is... Is there something else you want to do? 753 00:37:47,586 --> 00:37:48,563 Yes. 754 00:37:48,587 --> 00:37:50,500 ♪ What you're doing here? ♪ 755 00:37:50,524 --> 00:37:52,423 I want to be your husband. 756 00:37:59,719 --> 00:38:03,201 I realized I was so... 757 00:38:03,257 --> 00:38:06,455 afraid of losing you in the future... 758 00:38:09,067 --> 00:38:10,444 I was losing you now. 759 00:38:38,392 --> 00:38:40,025 Sorry. 760 00:38:40,065 --> 00:38:43,040 I hear your VC contact decided to quit the business. 761 00:38:45,049 --> 00:38:46,660 He did the right thing. 762 00:38:51,683 --> 00:38:53,893 ♪ Baby, don't lie to me ♪ 763 00:38:53,917 --> 00:38:55,421 You know... 764 00:38:56,822 --> 00:38:59,534 my feet are killing me. 765 00:39:21,927 --> 00:39:25,007 I'm open. To being friends. 766 00:39:25,048 --> 00:39:26,194 That's great. 767 00:39:26,231 --> 00:39:28,954 I'm open, too, to wherever this goes. 768 00:39:29,882 --> 00:39:32,360 It's going to friendship. 769 00:39:32,657 --> 00:39:34,001 Understood. 770 00:39:34,026 --> 00:39:35,581 But life is about change, 771 00:39:35,606 --> 00:39:37,217 which means, one day, you might change your mind. 772 00:39:37,242 --> 00:39:39,788 And if you did, I'd be open to that, too. 773 00:39:39,813 --> 00:39:41,313 It's not gonna happen. 774 00:39:44,163 --> 00:39:45,240 Okay. 775 00:39:53,410 --> 00:39:54,646 _ 776 00:39:54,670 --> 00:39:56,670 _ 777 00:39:56,704 --> 00:39:58,704 _ 778 00:40:05,937 --> 00:40:08,216 First, there should be no soap involved. 779 00:40:08,241 --> 00:40:10,119 Also, we need to stay at one end of the shower, 780 00:40:10,144 --> 00:40:13,556 so we don't accidentally knock into the temperature control. 781 00:40:13,965 --> 00:40:15,976 What changed your mind? 782 00:40:16,194 --> 00:40:19,207 I've been thinking about change over time. 783 00:40:19,232 --> 00:40:21,110 I spoke with people and also graphed 784 00:40:21,135 --> 00:40:22,712 several possibilities for us, 785 00:40:22,737 --> 00:40:24,549 using time as the horizontal axis 786 00:40:24,574 --> 00:40:25,817 and change as the vertical. 787 00:40:25,842 --> 00:40:28,955 I realized that the problem isn't really change. 788 00:40:28,980 --> 00:40:33,127 It's whether two people change in the same direction. 789 00:40:33,152 --> 00:40:35,174 We want to keep our coordinates close to each other 790 00:40:35,199 --> 00:40:37,164 for the rest of our lives. 791 00:40:38,630 --> 00:40:40,442 We certainly do. 792 00:40:41,127 --> 00:40:43,979 But people sometimes do drift apart. 793 00:40:44,004 --> 00:40:45,082 Yes. 794 00:40:45,119 --> 00:40:47,485 You need a warning when you and your partner 795 00:40:47,510 --> 00:40:48,921 might be starting to veer off, 796 00:40:48,946 --> 00:40:50,623 so you can both change course a little. 797 00:40:50,648 --> 00:40:52,893 You don't want a surprise realization when it's too late. 798 00:40:52,918 --> 00:40:54,296 Surprises are awful. 799 00:40:54,321 --> 00:40:57,466 The U.S. Army Signal Corps used flags to warn of hurricanes. 800 00:40:57,491 --> 00:40:59,469 I brought us this. 801 00:41:00,144 --> 00:41:02,712 A cowbell? 802 00:41:02,737 --> 00:41:05,883 If you see us heading in different directions, 803 00:41:05,908 --> 00:41:07,152 you ring it. 804 00:41:07,178 --> 00:41:09,723 Do we really need a bell? Can't I just tell you? 805 00:41:10,917 --> 00:41:13,162 Oh! When you ring it, I'll pay attention. 806 00:41:13,187 --> 00:41:14,698 I really hate the sound. 807 00:41:15,260 --> 00:41:17,730 Only in emergencies. 808 00:41:18,596 --> 00:41:21,917 I've already moved the shampoo bottles. 809 00:41:22,708 --> 00:41:23,852 What? 810 00:41:26,147 --> 00:41:27,591 Oh. 811 00:41:27,616 --> 00:41:29,361 You mean now? 812 00:41:32,790 --> 00:41:35,035 Don't worry about putting the bottles back. 813 00:41:35,060 --> 00:41:36,104 I'll do it later. 814 00:41:37,164 --> 00:41:39,161 I love you. 815 00:41:39,187 --> 00:41:42,046 It's no trouble. I remember where they all go.