1
00:00:03,307 --> 00:00:04,341
Those are yours.
2
00:00:05,176 --> 00:00:07,600
We bought them together.
3
00:00:07,624 --> 00:00:10,619
Because you "found the pattern soothing."
4
00:00:15,453 --> 00:00:18,665
♪
5
00:00:18,689 --> 00:00:20,504
I'm gonna miss you, Shaun.
6
00:00:21,359 --> 00:00:22,659
I love Carly.
7
00:00:24,996 --> 00:00:26,340
And that's great.
8
00:00:26,364 --> 00:00:28,566
I am so happy for you.
9
00:00:28,590 --> 00:00:33,680
Now you can hang the toilet paper
incorrectly anytime you want.
10
00:00:33,704 --> 00:00:35,406
And Carly and I can go back
11
00:00:35,430 --> 00:00:37,479
to the way things were before our fight.
12
00:00:38,923 --> 00:00:42,155
Well, sometimes couples need
a little time to recover.
13
00:00:42,179 --> 00:00:43,390
We won't.
14
00:00:43,414 --> 00:00:45,859
Carly asked for you to move out.
15
00:00:45,883 --> 00:00:48,085
You are moving out.
16
00:00:48,109 --> 00:00:51,012
♪
17
00:00:51,036 --> 00:00:53,439
How many kidneys do I need
in my body to attend prom?
18
00:00:53,463 --> 00:00:54,631
(CHUCKLING) Ryan...
19
00:00:54,655 --> 00:00:56,257
Even if the surgery removes my kidney,
20
00:00:56,281 --> 00:00:57,649
it'll be laparoscopic,
21
00:00:57,673 --> 00:01:00,676
so my inpatient time
will be seven days, tops.
22
00:01:00,700 --> 00:01:02,876
And then three more days of rest at home.
23
00:01:02,900 --> 00:01:04,798
I can take my girlfriend to prom, right?
24
00:01:05,936 --> 00:01:07,648
That's not a purely medical decision.
25
00:01:07,672 --> 00:01:09,182
I have to draw some blood.
26
00:01:09,206 --> 00:01:11,151
What are the chances
Dr. Melendez might be able
27
00:01:11,175 --> 00:01:13,220
to remove the tumor
but spare Ryan's kidney?
28
00:01:13,244 --> 00:01:15,055
Well, the MRI will let us know
29
00:01:15,079 --> 00:01:16,690
how much the chemo shrunk the tumor,
30
00:01:16,714 --> 00:01:19,050
but you shouldn't count on it.
31
00:01:19,074 --> 00:01:22,229
One chili burger,
extra mustard, extra pickles.
32
00:01:22,253 --> 00:01:24,031
Hi. Morning, Mr. Cooper.
33
00:01:24,055 --> 00:01:25,866
I'm not sure he can have
that with his surgery...
34
00:01:25,890 --> 00:01:28,071
Oh, he's fine until about 6:30 tonight.
35
00:01:28,793 --> 00:01:30,003
CLAIRE: I know you.
36
00:01:30,027 --> 00:01:32,739
Angie... Valens.
37
00:01:32,763 --> 00:01:34,241
I helped put in your chemo port.
38
00:01:34,265 --> 00:01:36,677
I owe you a big thank-you. (CHUCKLES)
39
00:01:36,701 --> 00:01:38,578
We met in chemo.
40
00:01:38,602 --> 00:01:40,714
They should put us in a public
service announcement or something.
41
00:01:40,738 --> 00:01:44,293
Yeah... "I lost a tumor and gained
a boyfriend. Thanks, chemo."
42
00:01:44,317 --> 00:01:45,809
(LAUGHTER)
43
00:01:48,546 --> 00:01:49,890
James McDougall?
44
00:01:49,914 --> 00:01:51,191
That's who we're here for, too.
45
00:01:51,215 --> 00:01:53,694
All of you can head over to Bay 4.
46
00:01:53,718 --> 00:01:55,896
Guy saw me six months ago
for a stress fracture.
47
00:01:55,920 --> 00:01:58,298
He's a lunatic ultra-marathoner.
48
00:01:58,322 --> 00:02:01,021
I just hope he didn't go too
hard too soon and break it again.
49
00:02:04,128 --> 00:02:05,628
(BREATHES SHAKILY)
50
00:02:07,298 --> 00:02:09,776
He didn't break it again.
51
00:02:09,800 --> 00:02:12,168
♪
52
00:02:13,220 --> 00:02:16,056
(THEME MUSIC PLAYING)
53
00:02:16,080 --> 00:02:24,091
Synced & corrected by -robtor-
www.addic7ed.com
54
00:02:24,115 --> 00:02:26,513
DR. LIM: Your GP was right to start
you on ketoprofen for the swelling,
55
00:02:26,537 --> 00:02:28,373
but clearly, it isn't working.
56
00:02:28,397 --> 00:02:29,823
That's why Drs. Murphy and Reznick
57
00:02:29,847 --> 00:02:31,998
are going to block off some
of your lymphatic channels.
58
00:02:32,022 --> 00:02:33,834
It should reduce production.
59
00:02:33,858 --> 00:02:36,064
The more pressing concern is why.
60
00:02:36,088 --> 00:02:38,558
Have you ever had surgery
on your lymph nodes?
61
00:02:39,529 --> 00:02:41,975
What about cancer or radiation treatment?
62
00:02:41,999 --> 00:02:44,144
No. Physically, I've always been healthy.
63
00:02:44,168 --> 00:02:45,421
Physically?
64
00:02:45,445 --> 00:02:48,735
I was diagnosed with Persistent
Depressive Disorder when I was 16.
65
00:02:50,040 --> 00:02:52,519
That's why you got to get me
back out on the road, Doc.
66
00:02:52,543 --> 00:02:54,688
Are antidepressants
not effective for you?
67
00:02:54,712 --> 00:02:56,289
I mean, they help.
68
00:02:56,313 --> 00:02:59,159
But running really is key.
69
00:02:59,183 --> 00:03:01,795
Saved my marriage and... And my life.
70
00:03:01,819 --> 00:03:04,047
Lymphedema can be caused by an infection.
71
00:03:04,071 --> 00:03:06,387
He doesn't have a fever.
72
00:03:06,411 --> 00:03:08,101
Ketoprofen can suppress fevers.
73
00:03:08,125 --> 00:03:09,292
Let's get some cultures
74
00:03:09,316 --> 00:03:11,352
and start him on broad-spec antibiotics.
75
00:03:11,376 --> 00:03:13,377
♪
76
00:03:15,900 --> 00:03:19,312
As requested, your restock on enemas.
77
00:03:19,336 --> 00:03:20,537
Nice cover.
78
00:03:22,072 --> 00:03:23,216
How've you been feeling?
79
00:03:23,240 --> 00:03:25,285
The methotrexate is working great.
80
00:03:25,309 --> 00:03:27,487
No pain, no redness.
81
00:03:27,511 --> 00:03:29,356
Stiffness, flu-like symptoms?
82
00:03:29,380 --> 00:03:30,792
No. All good.
83
00:03:30,816 --> 00:03:32,292
(FAUCET HANDLES SQUEAK)
84
00:03:32,316 --> 00:03:33,960
How long are you planning to hide out
85
00:03:33,984 --> 00:03:37,159
doing RA exams and clipping
diabetics' toenails?
86
00:03:37,988 --> 00:03:40,233
Dizziness, headaches, nausea?
87
00:03:40,257 --> 00:03:43,749
I... Sometimes I'm a little
queasy after I eat.
88
00:03:44,161 --> 00:03:46,752
You had to love neurosurgery.
89
00:03:47,665 --> 00:03:49,302
How about we try to get you a medication
90
00:03:49,326 --> 00:03:51,093
that doesn't irritate your stomach?
91
00:03:51,117 --> 00:03:53,717
No. My hands feel great.
That's all I care about.
92
00:03:54,839 --> 00:03:57,984
You used to open up skulls and
poke around people's brains.
93
00:03:58,008 --> 00:04:00,355
There's no way this fulfills you.
94
00:04:00,379 --> 00:04:02,189
I enjoy it.
95
00:04:02,213 --> 00:04:04,991
Or, rather, I usually enjoy it.
96
00:04:05,015 --> 00:04:06,693
(INHALES SHARPLY)
97
00:04:06,717 --> 00:04:08,398
I'll let you get back to it.
98
00:04:10,621 --> 00:04:12,682
Maybe someone out there needs an enema.
99
00:04:12,706 --> 00:04:14,224
(DOOR CLOSES)
100
00:04:15,693 --> 00:04:17,737
(MRI MACHINE HUMMING)
101
00:04:17,761 --> 00:04:19,372
Got a measurement on the Wilms tumor?
102
00:04:19,396 --> 00:04:21,508
Mm, not quite there yet.
103
00:04:21,532 --> 00:04:24,344
You mentioned 7 centimeters as our limit
104
00:04:24,368 --> 00:04:25,779
to doing this laparoscopically.
105
00:04:25,803 --> 00:04:27,914
What if we pushed it to 7.2?
106
00:04:27,938 --> 00:04:30,283
Would speed up recovery.
107
00:04:30,307 --> 00:04:31,755
By a few days.
108
00:04:33,277 --> 00:04:34,955
Forget I brought it up.
109
00:04:34,979 --> 00:04:37,457
Ryan wanting to take
his girlfriend to prom
110
00:04:37,481 --> 00:04:40,055
should not factor into our surgical plan.
111
00:04:40,918 --> 00:04:42,095
Is he nuts about her?
112
00:04:42,119 --> 00:04:44,965
Ohh. Crazy, head over heels in love.
113
00:04:44,989 --> 00:04:46,032
They both are.
114
00:04:46,056 --> 00:04:47,200
Idiots.
115
00:04:47,224 --> 00:04:49,302
(CHUCKLES)
116
00:04:49,326 --> 00:04:52,939
I wouldn't mind being
an idiot like that again.
117
00:04:52,963 --> 00:04:56,142
Though, I'm not sure
I ever felt that way,
118
00:04:56,166 --> 00:04:57,644
totally happy.
119
00:04:57,668 --> 00:04:59,095
So therapy's going well?
120
00:04:59,119 --> 00:05:00,580
(CHUCKLES)
121
00:05:00,604 --> 00:05:02,786
No metastasis in the lungs.
122
00:05:04,308 --> 00:05:05,509
Look at that.
123
00:05:05,533 --> 00:05:07,467
♪
124
00:05:11,348 --> 00:05:12,893
Your tumor is gone.
125
00:05:12,917 --> 00:05:14,417
(GASPS)
126
00:05:15,130 --> 00:05:16,497
Gone?
127
00:05:17,588 --> 00:05:19,165
How's that possible? (CHUCKLES)
128
00:05:19,189 --> 00:05:21,735
The chemotherapy worked
better than we expected.
129
00:05:21,759 --> 00:05:24,671
Wait, like, no tumor? Zero?
130
00:05:24,695 --> 00:05:27,140
- No need for surgery whatsoever?
- CLAIRE: That is right.
131
00:05:27,164 --> 00:05:29,009
These are discharge forms.
132
00:05:29,033 --> 00:05:30,777
(LAUGHS)
133
00:05:30,801 --> 00:05:32,145
(SQUEALS, GIGGLES)
134
00:05:32,169 --> 00:05:34,314
Both of my kidneys
are taking you to prom!
135
00:05:34,338 --> 00:05:35,749
Aah! Hell, yeah, we are!
136
00:05:35,773 --> 00:05:37,517
(LAUGHS)
137
00:05:37,541 --> 00:05:38,841
(LAUGHS)
138
00:05:40,444 --> 00:05:41,811
(CLEARS THROAT)
139
00:05:43,180 --> 00:05:44,514
Angie?
140
00:05:46,951 --> 00:05:48,695
- Angie!
- She's having a seizure!
141
00:05:48,719 --> 00:05:50,220
(GRUNTING)
142
00:05:50,244 --> 00:05:52,599
2 milligrams of lorazepam
and portable oxygen, stat.
143
00:05:52,623 --> 00:05:53,962
Let's get that under her head.
144
00:05:55,318 --> 00:05:57,352
(ALARM BLARING)
145
00:05:57,628 --> 00:05:59,092
His lungs are filled with fluid.
146
00:06:00,730 --> 00:06:03,366
I need a chest X-ray
and a bedside ultrasound.
147
00:06:03,390 --> 00:06:04,848
And page Dr. Reznick.
148
00:06:07,404 --> 00:06:09,149
(COUGHING)
149
00:06:09,173 --> 00:06:11,184
(PAGER BEEPING)
150
00:06:11,208 --> 00:06:13,209
♪
151
00:06:15,679 --> 00:06:16,813
(BEEPING CONTINUES)
152
00:06:17,824 --> 00:06:19,080
Imaging has confirmed
153
00:06:19,104 --> 00:06:21,239
a reoccurrence of your brain tumor.
154
00:06:22,181 --> 00:06:23,575
What stage?
155
00:06:24,517 --> 00:06:26,203
Three.
156
00:06:27,287 --> 00:06:30,598
DR. MELENDEZ: The best approach is
surgery, a wide resection of the tumor,
157
00:06:30,622 --> 00:06:33,543
followed by radiation and chemo
to encourage full remission.
158
00:06:34,827 --> 00:06:36,796
Sounds like a fun couple months.
159
00:06:37,297 --> 00:06:41,092
Full recovery will probably
take closer to eight.
160
00:06:42,502 --> 00:06:43,635
(SIGHS)
161
00:06:46,139 --> 00:06:48,099
We can get through this, baby,
just like last time.
162
00:06:50,476 --> 00:06:52,855
W-When will the surgery be?
163
00:06:52,879 --> 00:06:54,857
We need to do some additional imaging,
164
00:06:54,881 --> 00:06:56,358
and I'd like to consult a colleague
165
00:06:56,382 --> 00:06:57,826
about the best surgical approach.
166
00:06:57,850 --> 00:06:59,236
That'll take a few days.
167
00:07:00,900 --> 00:07:01,933
Take your time.
168
00:07:04,057 --> 00:07:05,057
Prom?
169
00:07:06,326 --> 00:07:07,536
(CHUCKLING) Yeah.
170
00:07:07,560 --> 00:07:09,062
Now that Ryan can go, I have to go.
171
00:07:09,086 --> 00:07:10,688
Honey.
172
00:07:10,712 --> 00:07:12,580
This is your health we're talking about.
173
00:07:12,604 --> 00:07:15,273
(VOICE BREAKING) Mom, please.
174
00:07:15,297 --> 00:07:17,599
I just want to do this one
thing like a normal kid.
175
00:07:19,005 --> 00:07:20,649
(SIGHS)
176
00:07:20,673 --> 00:07:22,259
Can you tell her it's okay?
177
00:07:24,010 --> 00:07:25,208
DR. PARK: We can't.
178
00:07:25,232 --> 00:07:26,536
Until we remove your tumor,
179
00:07:26,560 --> 00:07:28,515
you're at risk of
potentially fatal seizures.
180
00:07:30,883 --> 00:07:32,194
After you're recovered,
181
00:07:32,218 --> 00:07:33,920
you and Ryan can get all dressed up,
182
00:07:33,944 --> 00:07:36,356
and we'll go have dinner
at the Grandview. Okay?
183
00:07:43,062 --> 00:07:45,040
Prom sucks.
184
00:07:45,064 --> 00:07:46,709
My buddy had a fake ID.
185
00:07:46,733 --> 00:07:48,510
I got so drunk in the limo
that I passed out
186
00:07:48,534 --> 00:07:50,203
and never made it into the dance.
187
00:07:51,237 --> 00:07:53,290
Maybe that wasn't everybody's experience.
188
00:07:53,840 --> 00:07:55,834
I was prom king. My date was queen.
189
00:08:00,246 --> 00:08:01,787
I had the dress, I had the date,
190
00:08:01,811 --> 00:08:03,773
I had the mom who got arrested.
191
00:08:03,797 --> 00:08:05,928
Spent the night picking
her up from the drunk tank.
192
00:08:05,952 --> 00:08:07,029
Did you see Park while you were there?
193
00:08:07,053 --> 00:08:08,259
(LAUGHS)
194
00:08:08,283 --> 00:08:11,066
Go to scheduling, get Angie's
surgery set for Friday
195
00:08:11,090 --> 00:08:12,934
with the best neurosurgery OR nurses.
196
00:08:15,094 --> 00:08:16,395
Let's go see Glassman.
197
00:08:17,563 --> 00:08:18,798
DR. ANDREWS: Now I'm identifying
198
00:08:18,822 --> 00:08:20,590
the submillimeter lymphatic vessels.
199
00:08:20,614 --> 00:08:24,195
I need an 11-0 micro suture
and a 70 micron needle.
200
00:08:24,898 --> 00:08:27,305
Instead of harvesting nodes to this area,
201
00:08:27,329 --> 00:08:30,252
could we redirect lymphatics
away from his lymph system?
202
00:08:30,276 --> 00:08:31,420
DR. ANDREWS: We could.
203
00:08:31,444 --> 00:08:33,389
If you identify an appropriate vessel,
204
00:08:33,413 --> 00:08:35,257
you can make the connection.
205
00:08:35,281 --> 00:08:37,668
DR. LIM: We're clearly not
dealing with an infection.
206
00:08:37,692 --> 00:08:39,928
There must be a blockage
somewhere in his lymph system.
207
00:08:39,952 --> 00:08:41,864
Most likely cancer.
208
00:08:41,888 --> 00:08:45,100
SHAUN: His CBC didn't show
any abnormal cells.
209
00:08:45,124 --> 00:08:47,427
Lymphoma doesn't always show up.
210
00:08:47,451 --> 00:08:49,971
We need to run cytology
on his lymphatic fluid.
211
00:08:55,621 --> 00:08:57,923
It's either gonna be nasty or very nasty,
212
00:08:57,947 --> 00:09:01,917
depending upon how it attaches
to the thalamus and fornix.
213
00:09:01,941 --> 00:09:05,403
Which no imaging or testing
can possibly determine.
214
00:09:06,579 --> 00:09:08,090
So, our options are?
215
00:09:08,114 --> 00:09:11,727
Between an endoscopic approach
or an open anterior one.
216
00:09:11,751 --> 00:09:13,119
That is correct.
217
00:09:15,641 --> 00:09:20,002
I'd run a stereotactic MRI
with fiducials and DTI
218
00:09:20,026 --> 00:09:23,004
to gauge how close the white
matter tracts actually are.
219
00:09:24,263 --> 00:09:25,340
You should scrub in.
220
00:09:25,364 --> 00:09:27,009
(CHUCKLES)
221
00:09:27,033 --> 00:09:28,843
Another doctor can cover the clinic.
222
00:09:30,136 --> 00:09:33,039
I haven't been in an OR in over a year,
223
00:09:33,063 --> 00:09:35,098
and then, as a patient.
224
00:09:35,122 --> 00:09:37,186
I'm not asking you to cut.
225
00:09:37,210 --> 00:09:39,511
But it'd be a huge value
to have you there.
226
00:09:39,896 --> 00:09:41,590
(CHUCKLES SOFTLY)
227
00:09:41,614 --> 00:09:43,325
I appreciate that.
228
00:09:43,349 --> 00:09:44,693
I'll consider it.
229
00:09:44,717 --> 00:09:47,119
♪
230
00:09:52,158 --> 00:09:54,136
(DOOR OPENS)
231
00:09:54,160 --> 00:09:55,794
(DOOR CLOSES)
232
00:09:59,132 --> 00:10:02,177
Hello. We need to run cytology
on this lymphatic fluid.
233
00:10:02,201 --> 00:10:04,170
I would be happy to.
234
00:10:08,074 --> 00:10:09,968
Lea moved out this morning.
235
00:10:12,879 --> 00:10:14,823
- Thank you.
- You're welcome.
236
00:10:14,847 --> 00:10:16,725
Can you come over tonight?
237
00:10:16,749 --> 00:10:18,527
Uh, that probably won't work...
238
00:10:18,551 --> 00:10:20,145
Or we could go to your apartment?
239
00:10:21,554 --> 00:10:22,856
I can't.
240
00:10:24,924 --> 00:10:27,402
Lea said that it might take time
241
00:10:27,426 --> 00:10:29,371
for us to recover from our fight.
242
00:10:29,395 --> 00:10:31,140
But I told her that we were okay.
243
00:10:31,164 --> 00:10:33,266
We are.
244
00:10:33,290 --> 00:10:35,059
I made plans tonight.
245
00:10:35,083 --> 00:10:38,204
To hang out with a friend
who just got fired.
246
00:10:38,604 --> 00:10:40,957
But I would love to come over
tomorrow night.
247
00:10:41,440 --> 00:10:43,418
Okay.
248
00:10:43,442 --> 00:10:45,379
I'll put a rush on this test, too.
249
00:10:45,403 --> 00:10:47,570
♪
250
00:10:53,352 --> 00:10:56,064
Your lymphovenous
anastomosis technique...
251
00:10:56,088 --> 00:10:58,066
I was impressed.
252
00:10:58,090 --> 00:10:59,535
It's a little early in the morning
253
00:10:59,559 --> 00:11:00,917
to be sucking up, Reznick.
254
00:11:00,941 --> 00:11:03,105
Not for me.
I like to get a jump on things.
255
00:11:03,129 --> 00:11:05,407
I'm fascinated by the way
you use plastic procedures,
256
00:11:05,431 --> 00:11:08,301
like microsurgery,
in other surgical specialties.
257
00:11:08,325 --> 00:11:10,653
I thought it might make an
interesting topic for a paper.
258
00:11:11,270 --> 00:11:12,537
Want to write it with me?
259
00:11:14,140 --> 00:11:15,250
Yes.
260
00:11:15,274 --> 00:11:16,441
Let's talk and eat.
261
00:11:19,612 --> 00:11:20,912
That's not breakfast.
262
00:11:22,415 --> 00:11:24,092
I'm buying.
263
00:11:24,116 --> 00:11:26,228
What publications do you want to target?
264
00:11:26,252 --> 00:11:27,485
(SIGHS)
265
00:11:28,955 --> 00:11:31,157
Last time, Angie had
bad post-op vomiting.
266
00:11:31,181 --> 00:11:32,447
- Of course. I'll make note of it...
- Excuse me.
267
00:11:34,227 --> 00:11:37,206
She's asleep. She needs her rest.
268
00:11:37,230 --> 00:11:38,807
I'll wait out here until she's awake.
269
00:11:38,831 --> 00:11:40,742
Ryan, your immune system is weak.
270
00:11:40,766 --> 00:11:43,812
It would be so easy for you to
pick up a bug and pass it to Angie.
271
00:11:43,836 --> 00:11:45,747
I haven't been around
anyone but my dad. I swear.
272
00:11:45,771 --> 00:11:47,440
He could wear a mask.
273
00:11:51,744 --> 00:11:54,883
After Angie's surgery,
we'll see about arranging a visit.
274
00:11:54,907 --> 00:11:56,449
Please tell her Ryan came by.
275
00:11:59,685 --> 00:12:01,663
I'm sorry if I overstepped.
276
00:12:02,355 --> 00:12:03,966
I'd like to change Angie's status
277
00:12:03,990 --> 00:12:05,334
to "No visitors" on her chart.
278
00:12:05,358 --> 00:12:06,525
Yeah.
279
00:12:06,549 --> 00:12:08,717
♪
280
00:12:14,166 --> 00:12:15,611
Please take Mr. McDougall to his room.
281
00:12:15,635 --> 00:12:17,053
I'll be there in a moment.
282
00:12:19,105 --> 00:12:20,890
Is that James McDougall?
283
00:12:21,707 --> 00:12:23,518
- And the woman with him?
- His wife.
284
00:12:23,542 --> 00:12:25,454
- Is it cancer?
- (SIGHS)
285
00:12:25,478 --> 00:12:27,756
No... Worse.
286
00:12:27,780 --> 00:12:31,193
His lymphedema is caused
by a genetic mutation.
287
00:12:31,217 --> 00:12:33,662
If you don't find a
medication he responds to,
288
00:12:33,686 --> 00:12:36,031
he'll drown from the inside.
289
00:12:36,055 --> 00:12:37,822
♪
290
00:12:38,510 --> 00:12:41,322
The mutation is on James' ARAF gene...
291
00:12:41,346 --> 00:12:43,219
It makes an enzyme called kinase,
292
00:12:43,243 --> 00:12:45,426
which can cause cells to overproliferate.
293
00:12:45,450 --> 00:12:47,292
It's a genetic condition.
294
00:12:48,720 --> 00:12:50,362
What set it off now?
295
00:12:50,386 --> 00:12:51,829
Probably the stress fracture.
296
00:12:51,853 --> 00:12:53,401
Sent his immune system into overdrive,
297
00:12:53,425 --> 00:12:55,008
which fired up his lymphatic system.
298
00:12:55,868 --> 00:12:57,672
What treatment protocol
targets this mutation?
299
00:12:57,696 --> 00:12:59,607
An MEK inhibitor.
300
00:12:59,631 --> 00:13:01,092
The problem is, which one?
301
00:13:01,116 --> 00:13:04,434
There are 41 possibilities,
each with different side effects.
302
00:13:05,303 --> 00:13:06,437
Good luck.
303
00:13:06,936 --> 00:13:08,897
Well, I was hoping you could stay.
304
00:13:12,611 --> 00:13:14,611
Okay. Sure.
305
00:13:16,128 --> 00:13:17,262
(MRI MACHINE HUMMING)
306
00:13:17,286 --> 00:13:19,115
We need you to stay completely still.
307
00:13:20,458 --> 00:13:21,701
Not a problem.
308
00:13:23,588 --> 00:13:24,655
You okay?
309
00:13:25,957 --> 00:13:27,802
Ryan totally bailed.
310
00:13:27,826 --> 00:13:29,208
He hasn't come back to see me.
311
00:13:32,557 --> 00:13:34,393
If you tell her that her mom
said he couldn't visit,
312
00:13:34,417 --> 00:13:35,877
she'll be pissed at her mom.
313
00:13:35,901 --> 00:13:37,216
How's that gonna help?
314
00:13:39,738 --> 00:13:42,347
He's probably busy catching up in school.
315
00:13:45,577 --> 00:13:47,488
We had a pact.
316
00:13:47,512 --> 00:13:50,229
As long as we were together,
cancer wasn't gonna beat us.
317
00:13:51,450 --> 00:13:53,227
He broke it.
318
00:13:53,251 --> 00:13:54,595
Cancer wins.
319
00:13:54,619 --> 00:13:56,987
♪
320
00:14:00,043 --> 00:14:01,211
Do you mind finishing?
321
00:14:01,235 --> 00:14:02,769
(SIGHS)
322
00:14:05,430 --> 00:14:07,865
♪
323
00:14:13,472 --> 00:14:14,515
Imaging finished?
324
00:14:14,539 --> 00:14:15,917
Not quite.
325
00:14:15,941 --> 00:14:19,921
Mrs. Valens, Angie would
really like to see Ryan.
326
00:14:19,945 --> 00:14:21,689
I know you're concerned about infection,
327
00:14:21,713 --> 00:14:23,048
but there is minimal risk.
328
00:14:23,072 --> 00:14:26,057
Actually... Actually, none,
if they do a video chat.
329
00:14:26,952 --> 00:14:28,496
Interesting idea.
330
00:14:28,520 --> 00:14:29,769
I'll think about it.
331
00:14:32,524 --> 00:14:34,326
Angie's depressed.
332
00:14:34,350 --> 00:14:36,871
And studies have shown that
that can have a negative impact
333
00:14:36,895 --> 00:14:38,403
on her surgical outcome.
334
00:14:39,464 --> 00:14:41,476
(LAUGHS)
335
00:14:41,500 --> 00:14:45,046
Ryan doesn't always improve Angie's mood.
336
00:14:45,070 --> 00:14:47,405
A couple of weeks ago,
they had some silly fight,
337
00:14:47,429 --> 00:14:49,851
and she cried for days.
338
00:14:49,875 --> 00:14:51,619
Thank you for letting me know.
339
00:14:51,643 --> 00:14:53,154
I'm gonna do my best to cheer her up.
340
00:14:53,178 --> 00:14:55,156
She's a 16-year-old.
341
00:14:55,180 --> 00:14:56,557
She wants her boyfriend.
342
00:14:56,581 --> 00:14:58,226
Yeah.
343
00:14:58,250 --> 00:15:00,174
And how smart were you when you were 16?
344
00:15:07,759 --> 00:15:09,670
DR. REZNICK: Well,
what about Selumetinib?
345
00:15:09,694 --> 00:15:12,406
It's shown promising results
on related conditions.
346
00:15:12,430 --> 00:15:15,042
And a high occurrence of liver disease.
347
00:15:15,066 --> 00:15:18,735
Binimetinib is similar,
but has fewer complications.
348
00:15:19,504 --> 00:15:20,987
Any objections?
349
00:15:23,775 --> 00:15:25,116
Let's start James on that.
350
00:15:29,681 --> 00:15:30,714
(DOOR OPENS)
351
00:15:33,618 --> 00:15:36,697
This is exciting, working together.
352
00:15:36,721 --> 00:15:38,346
It is.
353
00:15:38,370 --> 00:15:42,925
Although, I'm used to samples
and slides instead of patients.
354
00:15:46,765 --> 00:15:49,544
Patients can be difficult.
355
00:15:49,568 --> 00:15:51,017
But you will be fine.
356
00:16:01,112 --> 00:16:03,914
♪
357
00:16:10,255 --> 00:16:11,422
Do you need something?
358
00:16:12,324 --> 00:16:13,801
(SIGHS)
359
00:16:13,825 --> 00:16:17,038
I was curious how James was
responding to the Binimetinib.
360
00:16:17,062 --> 00:16:18,272
His urine output is up,
361
00:16:18,296 --> 00:16:20,880
which suggests the lymphatic fluid...
362
00:16:21,900 --> 00:16:23,444
And his potassium is a little low.
363
00:16:23,468 --> 00:16:25,003
Can you... give him this?
364
00:16:25,027 --> 00:16:26,047
I wasn't really...
365
00:16:26,071 --> 00:16:28,639
♪
366
00:16:42,921 --> 00:16:43,998
Hi.
367
00:16:44,022 --> 00:16:45,766
I'm Dr. Lever.
368
00:16:45,790 --> 00:16:47,692
The tumor's abutting
and possibly infiltrating
369
00:16:47,716 --> 00:16:49,451
the white matter tracts of her fornix.
370
00:16:49,475 --> 00:16:51,305
We'll likely have to remove a section.
371
00:16:51,329 --> 00:16:53,741
That'll affect her ability
to form memories.
372
00:16:53,765 --> 00:16:55,109
With a lot of neuropsych rehab,
373
00:16:55,133 --> 00:16:57,871
she may be able to compensate
with other pathways.
374
00:16:57,895 --> 00:17:01,281
Studies have shown that positive
attitudes lead to positive outcomes.
375
00:17:01,305 --> 00:17:02,406
You're worried about her attitude?
376
00:17:02,430 --> 00:17:03,831
She's worried about young love.
377
00:17:03,855 --> 00:17:05,957
I'm worried about what Angie
is facing after surgery.
378
00:17:05,981 --> 00:17:08,350
Physical therapy, cognitive therapy,
379
00:17:08,374 --> 00:17:09,809
one challenge after another.
380
00:17:09,833 --> 00:17:11,472
And what she wants is so simple.
381
00:17:13,952 --> 00:17:15,434
You want to make a sad kid happy?
382
00:17:17,194 --> 00:17:18,362
I guess I do.
383
00:17:18,386 --> 00:17:20,187
Which isn't my job, and I need to stop
384
00:17:20,211 --> 00:17:21,679
getting sucked into
people's personal issues.
385
00:17:21,703 --> 00:17:23,985
Is there a way to do that
without antagonizing the mother?
386
00:17:27,899 --> 00:17:29,310
Maybe.
387
00:17:29,334 --> 00:17:30,402
(ELEVATOR BELL DINGS)
388
00:17:30,426 --> 00:17:31,701
Then make her happy.
389
00:17:35,974 --> 00:17:37,718
(BOTH BREATHING HEAVILY)
390
00:17:37,742 --> 00:17:40,577
♪
391
00:17:41,713 --> 00:17:43,080
(GIGGLES)
392
00:17:48,920 --> 00:17:51,499
We've never gotten this far before.
393
00:17:51,523 --> 00:17:52,667
No.
394
00:17:52,691 --> 00:17:54,301
We haven't.
395
00:17:54,325 --> 00:17:55,359
And you're okay?
396
00:17:56,828 --> 00:17:58,352
I am very okay.
397
00:18:07,038 --> 00:18:08,182
(GASPS)
398
00:18:08,206 --> 00:18:09,250
Carly.
399
00:18:09,274 --> 00:18:10,851
Ohh.
400
00:18:10,875 --> 00:18:12,276
(LAUGHS)
401
00:18:24,422 --> 00:18:25,522
Okay.
402
00:18:32,697 --> 00:18:35,599
Did... I do something wrong?
403
00:18:36,868 --> 00:18:38,809
No, I'm sorry. It's me.
404
00:18:40,038 --> 00:18:43,517
You said we were okay.
405
00:18:43,541 --> 00:18:44,919
I thought we were.
406
00:18:44,943 --> 00:18:46,120
I-I want us to be.
407
00:18:46,144 --> 00:18:48,222
You have no reason to still be mad.
408
00:18:48,246 --> 00:18:49,523
I'm not mad.
409
00:18:49,547 --> 00:18:50,891
I'm... I'm just...
410
00:18:50,915 --> 00:18:52,783
(CELL PHONE BEEPING)
411
00:18:57,381 --> 00:18:58,582
It's Morgan.
412
00:18:58,606 --> 00:19:01,910
The medication caused James
an upper GI bleed.
413
00:19:01,934 --> 00:19:04,703
♪
414
00:19:08,230 --> 00:19:09,875
Have you localized
the source of the bleeding?
415
00:19:09,899 --> 00:19:11,116
Working on it.
416
00:19:11,140 --> 00:19:13,412
Seems to be coming from
the antrum of the stomach.
417
00:19:13,436 --> 00:19:15,272
DR. REZNICK: We stopped the Binimetinib.
418
00:19:15,296 --> 00:19:17,716
On top of causing this, it hadn't
done much to curtail the swelling.
419
00:19:17,740 --> 00:19:19,117
Where's Dr. Lever?
420
00:19:19,141 --> 00:19:21,077
DR. ANDREWS: There's the
ulcerative lesion. Cautery.
421
00:19:24,313 --> 00:19:26,224
Zebrafish.
422
00:19:26,248 --> 00:19:27,459
They're used in medical research
423
00:19:27,483 --> 00:19:28,984
because of their quick maturation,
424
00:19:29,008 --> 00:19:31,778
and 84% of genes associated
with human disease
425
00:19:31,802 --> 00:19:33,637
have a zebrafish equivalent.
426
00:19:33,661 --> 00:19:37,031
You think we should do
a transgenic expression
427
00:19:37,055 --> 00:19:41,158
of James' ARAF mutation
into the zebrafish genome.
428
00:19:41,182 --> 00:19:42,441
Translation for those of us
429
00:19:42,465 --> 00:19:44,276
without a genetics textbook handy?
430
00:19:44,300 --> 00:19:46,611
We make mini-Jameses, as zebrafish,
431
00:19:46,635 --> 00:19:48,170
all with the same disorder.
432
00:19:48,194 --> 00:19:51,383
Then we test every conceivable
drug on those fish.
433
00:19:51,407 --> 00:19:52,918
How long before we can start testing?
434
00:19:52,942 --> 00:19:54,586
If we implant the embryos now,
435
00:19:54,610 --> 00:19:56,388
probably by late afternoon tomorrow.
436
00:19:56,412 --> 00:19:57,577
Get going.
437
00:19:57,601 --> 00:19:59,658
Shaun, go with her.
You have Path experience.
438
00:19:59,682 --> 00:20:01,793
♪
439
00:20:01,817 --> 00:20:03,518
(DOOR OPENS)
440
00:20:20,836 --> 00:20:24,015
I understand no means no.
441
00:20:24,039 --> 00:20:27,475
If you don't want to have sex,
442
00:20:27,877 --> 00:20:29,544
I accept that.
443
00:20:29,831 --> 00:20:32,214
But I am very confused.
444
00:20:32,548 --> 00:20:34,493
So am I.
445
00:20:34,517 --> 00:20:36,595
I thought I was fine u-until I...
446
00:20:36,619 --> 00:20:40,665
I told Lea to move out, like you wanted.
447
00:20:40,689 --> 00:20:43,809
You said that things were okay.
448
00:20:44,193 --> 00:20:46,854
They aren't. How do I make them okay?
449
00:20:47,696 --> 00:20:50,107
I can't tell you, because I don't know.
450
00:20:51,300 --> 00:20:54,536
♪
451
00:21:14,657 --> 00:21:16,091
When I was in chemo,
452
00:21:16,115 --> 00:21:18,384
the nurses used to force
that stuff down my throat,
453
00:21:18,408 --> 00:21:21,006
so I know you're not drinking
it because of the taste.
454
00:21:21,030 --> 00:21:22,207
(CHUCKLES LIGHTLY)
455
00:21:22,231 --> 00:21:23,875
It's fast, easy nutrition.
456
00:21:23,899 --> 00:21:26,852
That and you don't end up puking
your guts out in the bathroom.
457
00:21:28,463 --> 00:21:30,999
I was president of this
hospital for over 10 years.
458
00:21:31,023 --> 00:21:33,693
I made a few friends,
including Jack the janitor...
459
00:21:33,717 --> 00:21:36,821
Talks a lot, A's fan, horrible gossip.
460
00:21:36,845 --> 00:21:39,281
If the methotrexate is making you sick,
461
00:21:39,305 --> 00:21:40,991
we should try another medication.
462
00:21:43,785 --> 00:21:46,388
How can you guarantee
that you're not gonna throw up
463
00:21:46,412 --> 00:21:48,012
in the middle of your next surgery?
464
00:21:48,876 --> 00:21:50,277
It won't happen.
465
00:21:51,694 --> 00:21:54,206
Because it only happens
if I eat solid food.
466
00:21:54,230 --> 00:21:55,714
And I stopped.
467
00:21:57,024 --> 00:21:58,291
At least at work.
468
00:22:05,520 --> 00:22:07,821
♪
469
00:22:10,079 --> 00:22:12,624
That is a lot of fish tanks.
470
00:22:12,648 --> 00:22:17,619
Forty. So we can test all of
the possible medications for...
471
00:22:17,876 --> 00:22:19,444
Are you throwing a party?
472
00:22:19,468 --> 00:22:20,634
Hope so.
473
00:22:33,469 --> 00:22:34,636
How are you doing, Shaun?
474
00:22:36,105 --> 00:22:37,840
Since your father passed away?
475
00:22:40,109 --> 00:22:44,096
I don't think about him very much.
476
00:22:48,484 --> 00:22:51,630
My mom... died recently.
477
00:22:51,654 --> 00:22:53,647
I-I don't know if you knew that.
478
00:22:55,291 --> 00:22:57,735
She pops into my head all the time.
479
00:22:59,628 --> 00:23:01,655
Not always the nicest thoughts.
480
00:23:08,270 --> 00:23:12,124
It's okay not to love them.
481
00:23:14,143 --> 00:23:15,644
They didn't make us who we are.
482
00:23:15,668 --> 00:23:18,103
♪
483
00:23:35,030 --> 00:23:37,665
♪
484
00:23:52,848 --> 00:23:54,382
Has your mom gone home?
485
00:23:56,978 --> 00:24:00,115
There is one more thing
we have to deal with tonight.
486
00:24:00,139 --> 00:24:01,800
(SCOFFS)
487
00:24:01,824 --> 00:24:03,335
Come on.
488
00:24:03,359 --> 00:24:05,803
How many more sets of imaging
can you possibly do?
489
00:24:07,663 --> 00:24:10,542
One of these is your prom dress.
490
00:24:10,566 --> 00:24:14,312
I like the pink, but I think
you'd look gorgeous in both.
491
00:24:14,336 --> 00:24:16,270
♪
492
00:24:18,040 --> 00:24:19,484
Hurry up and choose.
493
00:24:19,508 --> 00:24:21,068
Your date'll be here soon.
494
00:24:22,878 --> 00:24:24,512
(LAUGHS)
495
00:24:34,390 --> 00:24:36,333
All the medications are in.
496
00:24:37,076 --> 00:24:41,072
Which means more waiting
to see which medicine works.
497
00:24:41,096 --> 00:24:42,715
It's hard to be patient.
498
00:24:48,303 --> 00:24:52,016
Do you think the fish control
how they react to the meds?
499
00:24:52,474 --> 00:24:53,541
No.
500
00:24:54,877 --> 00:24:57,229
It's just how their bodies respond.
501
00:24:59,895 --> 00:25:01,900
That's how I felt last night.
502
00:25:04,486 --> 00:25:07,115
I thought I was ready
for us to be together,
503
00:25:07,139 --> 00:25:11,035
but my body had a different response.
504
00:25:13,262 --> 00:25:14,939
I can't turn that response off
505
00:25:14,963 --> 00:25:16,808
any more than these fish can control
506
00:25:16,832 --> 00:25:19,577
how their mutation reacts
to the medication.
507
00:25:19,601 --> 00:25:21,636
♪
508
00:25:25,841 --> 00:25:28,052
Was our mutation
509
00:25:28,076 --> 00:25:30,929
me going to Wyoming with Lea?
510
00:25:37,686 --> 00:25:41,857
Do you think we can find
our right medication?
511
00:25:55,137 --> 00:25:58,349
♪ I found a love ♪
512
00:25:58,373 --> 00:26:00,919
♪ For me ♪
513
00:26:00,943 --> 00:26:02,687
♪
514
00:26:02,711 --> 00:26:06,424
♪ Darling, just dive right in ♪
515
00:26:06,448 --> 00:26:08,549
♪ Follow my lead ♪
516
00:26:10,452 --> 00:26:13,832
♪ I found a girl ♪
517
00:26:13,856 --> 00:26:16,134
♪ Beautiful and sweet ♪
518
00:26:16,158 --> 00:26:18,002
You look amazing.
519
00:26:18,026 --> 00:26:22,974
♪ I never knew you were
the someone waiting for me
520
00:26:22,998 --> 00:26:24,476
So do you.
521
00:26:24,500 --> 00:26:29,147
♪ 'Cause we were just kids
when we fell in love
522
00:26:29,171 --> 00:26:33,218
♪ Not knowing what it was ♪
523
00:26:33,242 --> 00:26:40,158
♪ I will not give you up this time ♪
524
00:26:40,182 --> 00:26:44,229
♪ Darling, just kiss me slow ♪
525
00:26:44,253 --> 00:26:48,500
♪ Your heart is all I own ♪
526
00:26:48,524 --> 00:26:54,706
♪ And in your eyes, you're holding mine ♪
527
00:26:54,730 --> 00:26:58,476
♪ Baby, I'm ♪
528
00:26:58,500 --> 00:27:02,146
♪ Dancing in the dark ♪
529
00:27:02,170 --> 00:27:06,351
♪ With you between my arms ♪
530
00:27:06,375 --> 00:27:09,988
♪ Barefoot on the grass ♪
531
00:27:10,012 --> 00:27:13,448
♪ Listening to our favorite song ♪
532
00:27:13,472 --> 00:27:16,842
♪ When you said you looked a mess ♪
533
00:27:16,866 --> 00:27:20,265
♪ I whispered underneath my breath ♪
534
00:27:20,289 --> 00:27:21,566
Looks like you might be feeling
535
00:27:21,590 --> 00:27:24,202
a little idiotic happiness right now.
536
00:27:24,226 --> 00:27:25,703
Mm...
537
00:27:25,727 --> 00:27:27,572
Maybe a touch.
538
00:27:27,596 --> 00:27:30,097
♪
539
00:27:32,901 --> 00:27:34,679
♪ No, no ♪
540
00:27:34,703 --> 00:27:36,681
Dance with a prom king?
541
00:27:36,705 --> 00:27:38,750
Ohh. (LAUGHS)
542
00:27:38,774 --> 00:27:42,053
♪ You look perfect tonight ♪
543
00:27:42,077 --> 00:27:44,122
(LAUGHS)
544
00:27:44,146 --> 00:27:47,448
♪
545
00:27:55,257 --> 00:27:56,490
- (MONITOR BEEPING RAPIDLY)
- He's tachycardic.
546
00:27:58,927 --> 00:28:00,471
We were talking,
and then he just stopped.
547
00:28:00,495 --> 00:28:01,806
We need to do a pericardial tap.
548
00:28:01,830 --> 00:28:03,775
Call the cath lab.
Tell them we're coming.
549
00:28:03,799 --> 00:28:05,209
No time. We're doing it here.
550
00:28:05,233 --> 00:28:06,477
James, the pain in your chest
551
00:28:06,501 --> 00:28:08,079
is from too much fluid around your heart.
552
00:28:08,103 --> 00:28:09,881
We're gonna put a tube
into your chest to drain it.
553
00:28:09,905 --> 00:28:11,405
Call Shaun and Carly.
Tell them we're running out of time.
554
00:28:15,577 --> 00:28:21,092
♪ ...will be loving you till we're 70 ♪
555
00:28:21,116 --> 00:28:23,751
(CAMERA SHUTTER CLICKING)
556
00:28:25,854 --> 00:28:32,526
♪ And, baby, my heart could
still fall as hard at 23 ♪
557
00:28:35,964 --> 00:28:38,610
♪ And I'm thinking about how ♪
558
00:28:38,634 --> 00:28:43,815
♪ People fall in love
in mysterious ways ♪
559
00:28:43,839 --> 00:28:45,416
I brought Angie's Bearfeet Bear.
560
00:28:45,440 --> 00:28:47,209
It always makes her feel like sh...
561
00:28:50,812 --> 00:28:53,424
It's... prom.
562
00:28:53,448 --> 00:28:55,616
Ryan has been wearing his mask all night.
563
00:28:57,219 --> 00:29:01,699
♪ And I just want to tell you I am ♪
564
00:29:01,723 --> 00:29:04,525
♪ So, honey, now ♪
565
00:29:07,162 --> 00:29:09,897
♪ Take me into your loving arms ♪
566
00:29:11,400 --> 00:29:13,311
Don't let her stay up too late.
567
00:29:13,335 --> 00:29:17,538
♪ Kiss me under the light
of a thousand stars ♪
568
00:29:19,474 --> 00:29:22,009
♪ Place your hand on my beating heart ♪
569
00:29:24,346 --> 00:29:26,213
(FOOTSTEPS APPROACH)
570
00:29:28,250 --> 00:29:31,211
Morgan called. James isn't doing well.
571
00:29:37,192 --> 00:29:40,012
Cross SL-327 off the list.
572
00:29:40,862 --> 00:29:43,374
I see one...
573
00:29:43,398 --> 00:29:46,474
No, two tumors.
574
00:29:46,498 --> 00:29:48,502
♪
575
00:30:07,371 --> 00:30:08,473
Okay.
576
00:30:08,945 --> 00:30:10,657
This is my stop.
577
00:30:10,682 --> 00:30:12,426
I'll see you after.
578
00:30:12,451 --> 00:30:13,928
I love you.
579
00:30:13,953 --> 00:30:15,254
I love you, too, Mom.
580
00:30:19,002 --> 00:30:21,014
Don't worry. Okay?
581
00:30:21,238 --> 00:30:22,438
I got this.
582
00:30:24,989 --> 00:30:26,723
I know you do.
583
00:30:27,224 --> 00:30:28,935
(CHUCKLES)
584
00:30:28,959 --> 00:30:30,693
♪
585
00:30:33,230 --> 00:30:34,608
(CHUCKLES)
586
00:30:34,632 --> 00:30:35,709
Okay.
587
00:30:35,733 --> 00:30:36,777
Okay.
588
00:30:36,801 --> 00:30:39,135
♪
589
00:30:42,185 --> 00:30:46,370
What if I wake up and
don't remember Ryan at all?
590
00:30:49,980 --> 00:30:51,181
Then...
591
00:30:52,516 --> 00:30:55,253
You'll have the chance to fall
in love with him all over again.
592
00:30:59,990 --> 00:31:01,090
Okay.
593
00:31:02,626 --> 00:31:03,770
Okay.
594
00:31:03,795 --> 00:31:05,005
(BREATHES SHAKILY)
595
00:31:05,030 --> 00:31:07,132
♪
596
00:31:14,725 --> 00:31:16,912
We're down to five potential options.
597
00:31:16,937 --> 00:31:19,316
I don't need five potential.
I need one actual.
598
00:31:19,340 --> 00:31:21,017
There are two that best curb...
599
00:31:21,041 --> 00:31:22,008
Choose one.
600
00:31:23,143 --> 00:31:27,123
We should try Refametinib.
601
00:31:27,147 --> 00:31:28,959
It caused abnormal cell growth.
602
00:31:28,983 --> 00:31:30,288
Trametinib is safer.
603
00:31:31,118 --> 00:31:32,495
Which doesn't mean it's safe.
604
00:31:32,519 --> 00:31:33,830
Nothing's safe.
605
00:31:33,854 --> 00:31:34,960
Which do you want us to do?
606
00:31:37,124 --> 00:31:38,224
(SIGHS)
607
00:31:39,460 --> 00:31:40,770
Trametinib.
608
00:31:40,794 --> 00:31:42,439
That's the one.
609
00:31:42,463 --> 00:31:44,797
♪
610
00:31:48,235 --> 00:31:49,736
Saline in.
611
00:31:49,760 --> 00:31:52,382
Advancing scope
toward the third ventricle.
612
00:31:52,406 --> 00:31:54,351
Claire, hold gentle pressure on the tumor
613
00:31:54,375 --> 00:31:56,119
while I cut off its blood supply.
614
00:31:56,143 --> 00:31:58,211
(MONITORS BEEPING STEADILY)
615
00:32:02,816 --> 00:32:04,494
We've got some significant bleeding.
616
00:32:04,518 --> 00:32:06,116
Adjust the scope and suction.
617
00:32:11,025 --> 00:32:12,456
Look higher.
618
00:32:13,494 --> 00:32:14,971
Septal vein... There's your bleeder.
619
00:32:14,995 --> 00:32:16,418
Cauterize away.
620
00:32:28,542 --> 00:32:30,576
♪
621
00:33:01,642 --> 00:33:03,006
DR. MELENDEZ: Micro dissector.
622
00:33:08,115 --> 00:33:09,956
The tumor's immobile.
623
00:33:09,980 --> 00:33:12,028
I can't resect it without
injuring the nerve tracts.
624
00:33:12,052 --> 00:33:13,797
She'd be comatose.
625
00:33:13,821 --> 00:33:15,185
Try sharp dissection.
626
00:33:16,957 --> 00:33:18,569
- DR. MELENDEZ: I can't get a plane.
- DR. GLASSMAN: How bad?
627
00:33:18,593 --> 00:33:20,470
DR. MELENDEZ: It's completely
invaded her thalamus.
628
00:33:20,494 --> 00:33:24,069
Thin it out with a suction aspirator.
629
00:33:29,970 --> 00:33:31,481
DR. MELENDEZ: It's too adherent.
630
00:33:31,505 --> 00:33:33,245
If I keep going, I'm gonna kill her.
631
00:33:35,409 --> 00:33:36,609
Any ideas?
632
00:33:40,314 --> 00:33:42,648
♪
633
00:33:58,759 --> 00:34:02,274
Tell ICU Angie will be coming
sooner than we planned.
634
00:34:03,804 --> 00:34:05,171
Let's close her up.
635
00:34:22,885 --> 00:34:24,329
What's next?
636
00:34:24,353 --> 00:34:26,631
Another round of radiation, chemo?
637
00:34:29,625 --> 00:34:32,314
Her carcinoma is
638
00:34:32,338 --> 00:34:35,015
unlikely to respond to those therapies.
639
00:34:38,667 --> 00:34:41,021
No. We have to try.
640
00:34:42,004 --> 00:34:43,348
Angie will want to fight.
641
00:34:43,372 --> 00:34:44,683
- (MONITOR BEEPING RAPIDLY)
- She's seizing.
642
00:34:44,707 --> 00:34:45,951
Give me lorazepam and Dilantin, stat.
643
00:34:45,975 --> 00:34:47,285
Phenobarb and propofol on deck.
644
00:34:47,309 --> 00:34:49,811
♪
645
00:35:10,266 --> 00:35:11,426
You're crying.
646
00:35:14,937 --> 00:35:16,014
Yes.
647
00:35:19,708 --> 00:35:20,875
Why?
648
00:35:23,546 --> 00:35:26,024
I found James on Facebook.
649
00:35:26,048 --> 00:35:27,659
(SNIFFLES)
650
00:35:27,683 --> 00:35:30,236
He and Marjorie want to go to Costa Rica.
651
00:35:32,087 --> 00:35:35,834
Their dog is a three-legged
rescue named Tripod.
652
00:35:35,858 --> 00:35:37,892
♪
653
00:35:40,429 --> 00:35:42,540
He's not a slide. He's a person.
654
00:35:43,933 --> 00:35:45,377
He's a good person.
655
00:35:45,401 --> 00:35:47,179
And he might die.
656
00:35:47,203 --> 00:35:48,847
(SNIFFLES)
657
00:35:48,871 --> 00:35:50,924
This is why I like to stay in the lab.
658
00:35:56,378 --> 00:35:57,973
That...
659
00:35:58,614 --> 00:36:01,267
Is a very dumb thing to say.
660
00:36:04,046 --> 00:36:06,564
If you had stayed in the lab,
661
00:36:06,822 --> 00:36:10,026
James would probably be dead already.
662
00:36:12,728 --> 00:36:17,943
Your plan with the
zebrafish gave him a chance.
663
00:36:17,967 --> 00:36:23,748
It was a beautiful, perfect idea,
664
00:36:23,772 --> 00:36:26,451
from a beautiful, almost perfect person.
665
00:36:26,475 --> 00:36:28,309
♪
666
00:36:32,581 --> 00:36:35,393
Your earlobes are lopsided.
667
00:36:35,417 --> 00:36:36,951
(CHUCKLES)
668
00:37:08,884 --> 00:37:11,129
I'm so sorry.
669
00:37:11,153 --> 00:37:12,831
We couldn't save her.
670
00:37:12,855 --> 00:37:15,033
(BREATHING RAGGEDLY)
671
00:37:15,057 --> 00:37:17,825
♪
672
00:37:24,633 --> 00:37:26,334
(CRYING)
673
00:37:33,509 --> 00:37:35,076
Ms. Valens?
674
00:38:07,656 --> 00:38:09,437
Nice call on the zebrafish.
675
00:38:12,081 --> 00:38:14,492
(INAUDIBLE)
676
00:38:14,516 --> 00:38:16,718
♪
677
00:38:29,018 --> 00:38:31,129
About our paper, let's meet weekly.
678
00:38:31,154 --> 00:38:33,799
I'm thinking lunch every
Tuesday in the cafeteria.
679
00:38:33,902 --> 00:38:35,069
Perfect.
680
00:38:43,145 --> 00:38:45,557
(KNOCK ON DOOR)
681
00:38:45,581 --> 00:38:48,017
I heard about Melendez's patient.
682
00:38:51,453 --> 00:38:52,487
Yeah.
683
00:39:02,498 --> 00:39:04,242
You were right.
684
00:39:04,266 --> 00:39:08,413
I should probably try
another medication for my RA.
685
00:39:10,105 --> 00:39:11,624
I need solid food.
686
00:39:23,619 --> 00:39:25,180
DR. MELENDEZ: Claire? Wait up.
687
00:39:26,488 --> 00:39:27,999
You okay?
688
00:39:28,023 --> 00:39:30,101
Fine. I'm just tired.
689
00:39:32,101 --> 00:39:34,346
You did an amazing thing for Angie.
690
00:39:34,371 --> 00:39:37,483
You gave her mother a memory
that she will have forever.
691
00:39:37,508 --> 00:39:39,402
Well, it won't make up
for the daughter she lost.
692
00:39:40,102 --> 00:39:41,146
You're angry.
693
00:39:41,170 --> 00:39:43,648
I'm not. I am sad.
694
00:39:43,672 --> 00:39:45,650
- Who are you angry at?
- I'm not.
695
00:39:45,674 --> 00:39:46,785
Are you angry at me and Glassman
696
00:39:46,809 --> 00:39:47,952
because we couldn't save her?
697
00:39:47,976 --> 00:39:49,687
- No!
- At Angie?
698
00:39:49,711 --> 00:39:51,979
No, you can't be mad
at someone for dying!
699
00:39:53,315 --> 00:39:55,293
That's not true. You know that.
700
00:39:55,317 --> 00:39:57,662
♪
701
00:39:57,686 --> 00:39:59,364
She was sick.
702
00:39:59,388 --> 00:40:01,633
And she was trying to get better.
703
00:40:01,657 --> 00:40:03,986
She failed and left you alone.
704
00:40:04,010 --> 00:40:07,639
After you'd spent a lifetime
trying to take care of her.
705
00:40:07,663 --> 00:40:09,599
You have every reason
to be mad at your mother.
706
00:40:11,306 --> 00:40:13,017
I hate feeling this way.
707
00:40:13,042 --> 00:40:14,920
My whole life, I've been angry at her,
708
00:40:14,945 --> 00:40:16,856
and now it will never change.
709
00:40:18,040 --> 00:40:19,609
I don't know how to stop.
710
00:40:23,512 --> 00:40:25,890
Therapy will help.
711
00:40:25,914 --> 00:40:27,215
Time will help.
712
00:40:29,605 --> 00:40:31,773
There is one other thing
that's worked for me.
713
00:40:32,588 --> 00:40:34,222
♪
714
00:40:39,361 --> 00:40:40,472
(KEYS CLACK)
715
00:40:40,496 --> 00:40:42,240
(GIGGLES)
716
00:40:42,264 --> 00:40:44,375
♪
717
00:40:44,399 --> 00:40:46,367
Did we fix our mutation?
718
00:40:50,372 --> 00:40:51,439
(LAUGHS)
719
00:41:00,015 --> 00:41:01,659
That the best you got?
720
00:41:01,683 --> 00:41:04,685
♪