1
00:00:04,487 --> 00:00:05,521
Those are yours.
2
00:00:06,356 --> 00:00:08,780
We bought them together.
3
00:00:08,804 --> 00:00:11,799
Because you "found the pattern soothing".
4
00:00:16,633 --> 00:00:19,845
♪
5
00:00:19,869 --> 00:00:21,684
I'm gonna miss you, Shaun.
6
00:00:22,539 --> 00:00:23,839
I love Carly.
7
00:00:26,176 --> 00:00:27,520
And that's great.
8
00:00:27,544 --> 00:00:29,746
I am so happy for you.
9
00:00:29,770 --> 00:00:34,860
Now you can hang the toilet paper
incorrectly anytime you want.
10
00:00:34,884 --> 00:00:36,586
And Carly and I can go back
11
00:00:36,610 --> 00:00:38,659
to the way things were before our fight.
12
00:00:40,103 --> 00:00:43,335
Well, sometimes couples need
a little time to recover.
13
00:00:43,359 --> 00:00:44,570
We won't.
14
00:00:44,594 --> 00:00:47,039
Carly asked for you to move out.
15
00:00:47,063 --> 00:00:49,265
You are moving out.
16
00:00:49,289 --> 00:00:52,192
♪
17
00:00:52,216 --> 00:00:54,619
How many kidneys do I need
in my body to attend prom?
18
00:00:54,643 --> 00:00:55,811
(CHUCKLING) Ryan...
19
00:00:55,835 --> 00:00:57,437
Even if the surgery removes my kidney,
20
00:00:57,461 --> 00:00:58,829
it'll be laparoscopic,
21
00:00:58,853 --> 00:01:01,856
so my inpatient time
will be seven days, tops.
22
00:01:01,880 --> 00:01:04,056
And then three more days of rest at home.
23
00:01:04,080 --> 00:01:05,978
I can take my girlfriend to prom, right?
24
00:01:07,116 --> 00:01:08,828
That's not a purely medical decision.
25
00:01:08,852 --> 00:01:10,362
I have to draw some blood.
26
00:01:10,386 --> 00:01:12,331
What are the chances
Dr. Melendez might be able
27
00:01:12,355 --> 00:01:14,400
to remove the tumor
but spare Ryan's kidney?
28
00:01:14,424 --> 00:01:16,235
Well, the MRI will let us know
29
00:01:16,259 --> 00:01:17,870
how much the chemo shrunk the tumor,
30
00:01:17,894 --> 00:01:20,230
but you shouldn't count on it.
31
00:01:20,254 --> 00:01:23,409
One chili burger,
extra mustard, extra pickles.
32
00:01:23,433 --> 00:01:25,211
Hi. Morning, Mr. Cooper.
33
00:01:25,235 --> 00:01:27,046
I'm not sure he can have
that with his surgery...
34
00:01:27,070 --> 00:01:29,251
Oh, he's fine until about 6:30 tonight.
35
00:01:29,973 --> 00:01:31,183
CLAIRE: I know you.
36
00:01:31,207 --> 00:01:33,919
Angie... Valens.
37
00:01:33,943 --> 00:01:35,421
I helped put in your chemo port.
38
00:01:35,445 --> 00:01:37,857
I owe you a big thank-you. (CHUCKLES)
39
00:01:37,881 --> 00:01:39,758
We met in chemo.
40
00:01:39,782 --> 00:01:41,894
They should put us in a public
service announcement or something.
41
00:01:41,918 --> 00:01:45,473
Yeah... "I lost a tumor and gained
a boyfriend. Thanks, chemo."
42
00:01:45,497 --> 00:01:46,989
(LAUGHTER)
43
00:01:49,726 --> 00:01:51,070
James McDougall?
44
00:01:51,094 --> 00:01:52,371
That's who we're here for, too.
45
00:01:52,395 --> 00:01:54,874
All of you can head over to Bay 4.
46
00:01:54,898 --> 00:01:57,076
Guy saw me six months ago
for a stress fracture.
47
00:01:57,100 --> 00:01:59,478
He's a lunatic ultra-marathoner.
48
00:01:59,502 --> 00:02:02,201
I just hope he didn't go too
hard too soon and break it again.
49
00:02:05,308 --> 00:02:06,808
(BREATHES SHAKILY)
50
00:02:08,478 --> 00:02:10,956
He didn't break it again.
51
00:02:10,980 --> 00:02:13,348
♪
52
00:02:14,400 --> 00:02:17,236
(THEME MUSIC PLAYING)
53
00:02:17,260 --> 00:02:18,660
Synced & corrected by -robtor-
www.addic7ed.com
54
00:02:25,295 --> 00:02:27,693
DR. LIM: Your GP was right to start
you on ketoprofen for the swelling,
55
00:02:27,717 --> 00:02:29,553
but clearly, it isn't working.
56
00:02:29,577 --> 00:02:31,003
That's why Drs. Murphy and Reznick
57
00:02:31,027 --> 00:02:33,178
are going to block off some
of your lymphatic channels.
58
00:02:33,202 --> 00:02:35,014
It should reduce production.
59
00:02:35,038 --> 00:02:37,244
The more pressing concern is why.
60
00:02:37,268 --> 00:02:39,738
Have you ever had surgery
on your lymph nodes?
61
00:02:40,709 --> 00:02:43,155
What about cancer or radiation treatment?
62
00:02:43,179 --> 00:02:45,324
No. Physically, I've always been healthy.
63
00:02:45,348 --> 00:02:46,601
Physically?
64
00:02:46,625 --> 00:02:49,915
I was diagnosed with Persistent
Depressive Disorder when I was 16.
65
00:02:51,220 --> 00:02:53,699
That's why you got to get me
back out on the road, Doc.
66
00:02:53,723 --> 00:02:55,868
Are antidepressants
not effective for you?
67
00:02:55,892 --> 00:02:57,469
I mean, they help.
68
00:02:57,493 --> 00:03:00,339
But running really is key.
69
00:03:00,363 --> 00:03:02,975
Saved my marriage and... And my life.
70
00:03:02,999 --> 00:03:05,227
Lymphedema can be caused by an infection.
71
00:03:05,251 --> 00:03:07,567
He doesn't have a fever.
72
00:03:07,591 --> 00:03:09,281
Ketoprofen can suppress fevers.
73
00:03:09,305 --> 00:03:10,472
Let's get some cultures
74
00:03:10,496 --> 00:03:12,532
and start him on broad-spec antibiotics.
75
00:03:12,556 --> 00:03:14,557
♪
76
00:03:17,080 --> 00:03:20,492
As requested, your restock on enemas.
77
00:03:20,516 --> 00:03:21,717
Nice cover.
78
00:03:23,252 --> 00:03:24,396
How've you been feeling?
79
00:03:24,420 --> 00:03:26,465
The methotrexate is working great.
80
00:03:26,489 --> 00:03:28,667
No pain, no redness.
81
00:03:28,691 --> 00:03:30,536
Stiffness, flu-like symptoms?
82
00:03:30,560 --> 00:03:31,972
No. All good.
83
00:03:31,996 --> 00:03:33,472
(FAUCET HANDLES SQUEAK)
84
00:03:33,496 --> 00:03:35,140
How long are you planning to hide out
85
00:03:35,164 --> 00:03:38,339
doing RA exams and clipping
diabetics' toenails?
86
00:03:39,168 --> 00:03:41,413
Dizziness, headaches, nausea?
87
00:03:41,437 --> 00:03:44,929
I... Sometimes I'm a little
queasy after I eat.
88
00:03:45,341 --> 00:03:47,932
You had to love neurosurgery.
89
00:03:48,845 --> 00:03:50,482
How about we try to get you a medication
90
00:03:50,506 --> 00:03:52,273
that doesn't irritate your stomach?
91
00:03:52,297 --> 00:03:54,897
No. My hands feel great.
That's all I care about.
92
00:03:56,019 --> 00:03:59,164
You used to open up skulls and
poke around people's brains.
93
00:03:59,188 --> 00:04:01,535
There's no way this fulfills you.
94
00:04:01,559 --> 00:04:03,369
I enjoy it.
95
00:04:03,393 --> 00:04:06,171
Or, rather, I usually enjoy it.
96
00:04:06,195 --> 00:04:07,873
(INHALES SHARPLY)
97
00:04:07,897 --> 00:04:09,578
I'll let you get back to it.
98
00:04:11,801 --> 00:04:13,862
Maybe someone out there needs an enema.
99
00:04:13,886 --> 00:04:15,404
(DOOR CLOSES)
100
00:04:16,873 --> 00:04:18,917
(MRI MACHINE HUMMING)
101
00:04:18,941 --> 00:04:20,552
Got a measurement on the Wilms tumor?
102
00:04:20,576 --> 00:04:22,688
Mm, not quite there yet.
103
00:04:22,712 --> 00:04:25,524
You mentioned 7 centimeters as our limit
104
00:04:25,548 --> 00:04:26,959
to doing this laparoscopically.
105
00:04:26,983 --> 00:04:29,094
What if we pushed it to 7.2?
106
00:04:29,118 --> 00:04:31,463
Would speed up recovery.
107
00:04:31,487 --> 00:04:32,935
By a few days.
108
00:04:34,457 --> 00:04:36,135
Forget I brought it up.
109
00:04:36,159 --> 00:04:38,637
Ryan wanting to take
his girlfriend to prom
110
00:04:38,661 --> 00:04:41,235
should not factor into our surgical plan.
111
00:04:42,098 --> 00:04:43,275
Is he nuts about her?
112
00:04:43,299 --> 00:04:46,145
Ohh. Crazy, head over heels in love.
113
00:04:46,169 --> 00:04:47,212
They both are.
114
00:04:47,236 --> 00:04:48,380
Idiots.
115
00:04:48,404 --> 00:04:50,482
(CHUCKLES)
116
00:04:50,506 --> 00:04:54,119
I wouldn't mind being
an idiot like that again.
117
00:04:54,143 --> 00:04:57,322
Though, I'm not sure
I ever felt that way,
118
00:04:57,346 --> 00:04:58,824
totally happy.
119
00:04:58,848 --> 00:05:00,275
So therapy's going well?
120
00:05:00,299 --> 00:05:01,760
(CHUCKLES)
121
00:05:01,784 --> 00:05:03,966
No metastasis in the lungs.
122
00:05:05,488 --> 00:05:06,689
Look at that.
123
00:05:06,713 --> 00:05:08,647
♪
124
00:05:12,528 --> 00:05:14,073
Your tumor is gone.
125
00:05:14,097 --> 00:05:15,597
(GASPS)
126
00:05:16,310 --> 00:05:17,677
Gone?
127
00:05:18,768 --> 00:05:20,345
How's that possible? (CHUCKLES)
128
00:05:20,369 --> 00:05:22,915
The chemotherapy worked
better than we expected.
129
00:05:22,939 --> 00:05:25,851
Wait, like, no tumor? Zero?
130
00:05:25,875 --> 00:05:28,320
- No need for surgery whatsoever?
- CLAIRE: That is right.
131
00:05:28,344 --> 00:05:30,189
These are discharge forms.
132
00:05:30,213 --> 00:05:31,957
(LAUGHS)
133
00:05:31,981 --> 00:05:33,325
(SQUEALS, GIGGLES)
134
00:05:33,349 --> 00:05:35,494
Both of my kidneys
are taking you to prom!
135
00:05:35,518 --> 00:05:36,929
Aah! Hell, yeah, we are!
136
00:05:36,953 --> 00:05:38,697
(LAUGHS)
137
00:05:38,721 --> 00:05:40,021
(LAUGHS)
138
00:05:41,624 --> 00:05:42,991
(CLEARS THROAT)
139
00:05:44,360 --> 00:05:45,694
Angie?
140
00:05:48,131 --> 00:05:49,875
- Angie!
- She's having a seizure!
141
00:05:49,899 --> 00:05:51,400
(GRUNTING)
142
00:05:51,424 --> 00:05:53,779
2 milligrams of lorazepam
and portable oxygen, stat.
143
00:05:53,803 --> 00:05:55,142
Let's get that under her head.
144
00:05:56,498 --> 00:05:58,532
(ALARM BLARING)
145
00:05:58,808 --> 00:06:00,272
His lungs are filled with fluid.
146
00:06:01,910 --> 00:06:04,546
I need a chest X-ray
and a bedside ultrasound.
147
00:06:04,570 --> 00:06:06,028
And page Dr. Reznick.
148
00:06:08,584 --> 00:06:10,329
(COUGHING)
149
00:06:10,353 --> 00:06:12,364
(PAGER BEEPING)
150
00:06:12,388 --> 00:06:14,389
♪
151
00:06:16,859 --> 00:06:17,993
(BEEPING CONTINUES)
152
00:06:21,084 --> 00:06:22,340
Imaging has confirmed
153
00:06:22,364 --> 00:06:24,499
a reoccurrence of your brain tumor.
154
00:06:25,441 --> 00:06:26,835
What stage?
155
00:06:27,777 --> 00:06:29,463
Three.
156
00:06:30,547 --> 00:06:33,858
DR. MELENDEZ: The best approach is
surgery, a wide resection of the tumor,
157
00:06:33,882 --> 00:06:36,803
followed by radiation and chemo
to encourage full remission.
158
00:06:38,087 --> 00:06:40,056
Sounds like a fun couple months.
159
00:06:40,557 --> 00:06:44,352
Full recovery will probably
take closer to eight.
160
00:06:45,762 --> 00:06:46,895
(SIGHS)
161
00:06:49,399 --> 00:06:51,359
We can get through this, baby,
just like last time.
162
00:06:53,736 --> 00:06:56,115
W-When will the surgery be?
163
00:06:56,139 --> 00:06:58,117
We need to do some additional imaging,
164
00:06:58,141 --> 00:06:59,618
and I'd like to consult a colleague
165
00:06:59,642 --> 00:07:01,086
about the best surgical approach.
166
00:07:01,110 --> 00:07:02,496
That'll take a few days.
167
00:07:04,160 --> 00:07:05,193
Take your time.
168
00:07:07,317 --> 00:07:08,317
Prom?
169
00:07:09,586 --> 00:07:10,796
(CHUCKLING) Yeah.
170
00:07:10,820 --> 00:07:12,322
Now that Ryan can go, I have to go.
171
00:07:12,346 --> 00:07:13,948
Honey.
172
00:07:13,972 --> 00:07:15,840
This is your health we're talking about.
173
00:07:15,864 --> 00:07:18,533
(VOICE BREAKING) Mom, please.
174
00:07:18,557 --> 00:07:20,859
I just want to do this one
thing like a normal kid.
175
00:07:22,265 --> 00:07:23,909
(SIGHS)
176
00:07:23,933 --> 00:07:25,519
Can you tell her it's okay?
177
00:07:27,270 --> 00:07:28,468
DR. PARK: We can't.
178
00:07:28,492 --> 00:07:29,796
Until we remove your tumor,
179
00:07:29,820 --> 00:07:31,775
you're at risk of
potentially fatal seizures.
180
00:07:34,143 --> 00:07:35,454
After you're recovered,
181
00:07:35,478 --> 00:07:37,180
you and Ryan can get all dressed up,
182
00:07:37,204 --> 00:07:39,616
and we'll go have dinner
at the Grandview. Okay?
183
00:07:46,322 --> 00:07:48,300
Prom sucks.
184
00:07:48,324 --> 00:07:49,969
My buddy had a fake ID.
185
00:07:49,993 --> 00:07:51,770
I got so drunk in the limo
that I passed out
186
00:07:51,794 --> 00:07:53,463
and never made it into the dance.
187
00:07:54,497 --> 00:07:56,550
Maybe that wasn't everybody's experience.
188
00:07:57,100 --> 00:07:59,094
I was prom king. My date was queen.
189
00:08:03,506 --> 00:08:05,047
I had the dress, I had the date,
190
00:08:05,071 --> 00:08:07,033
I had the mom who got arrested.
191
00:08:07,057 --> 00:08:09,188
Spent the night picking
her up from the drunk tank.
192
00:08:09,212 --> 00:08:10,289
Did you see Park while you were there?
193
00:08:10,313 --> 00:08:11,519
(LAUGHS)
194
00:08:11,543 --> 00:08:14,326
Go to scheduling, get Angie's
surgery set for Friday
195
00:08:14,350 --> 00:08:16,194
with the best neurosurgery OR nurses.
196
00:08:18,354 --> 00:08:19,655
Let's go see Glassman.
197
00:08:20,823 --> 00:08:22,058
DR. ANDREWS: Now I'm identifying
198
00:08:22,082 --> 00:08:23,850
the submillimeter lymphatic vessels.
199
00:08:23,874 --> 00:08:27,455
I need an 11-0 micro suture
and a 70 micron needle.
200
00:08:28,158 --> 00:08:30,565
Instead of harvesting nodes to this area,
201
00:08:30,589 --> 00:08:33,512
could we redirect lymphatics
away from his lymph system?
202
00:08:33,536 --> 00:08:34,680
DR. ANDREWS: We could.
203
00:08:34,704 --> 00:08:36,649
If you identify an appropriate vessel,
204
00:08:36,673 --> 00:08:38,517
you can make the connection.
205
00:08:38,541 --> 00:08:40,928
DR. LIM: We're clearly not
dealing with an infection.
206
00:08:40,952 --> 00:08:43,188
There must be a blockage
somewhere in his lymph system.
207
00:08:43,212 --> 00:08:45,124
Most likely cancer.
208
00:08:45,148 --> 00:08:48,360
SHAUN: His CBC didn't show
any abnormal cells.
209
00:08:48,384 --> 00:08:50,687
Lymphoma doesn't always show up.
210
00:08:50,711 --> 00:08:53,231
We need to run cytology
on his lymphatic fluid.
211
00:08:58,881 --> 00:09:01,183
It's either gonna be nasty or very nasty,
212
00:09:01,207 --> 00:09:05,177
depending upon how it attaches
to the thalamus and fornix.
213
00:09:05,201 --> 00:09:08,663
Which no imaging or testing
can possibly determine.
214
00:09:09,839 --> 00:09:11,350
So, our options are?
215
00:09:11,374 --> 00:09:14,987
Between an endoscopic approach
or an open anterior one.
216
00:09:15,011 --> 00:09:16,379
That is correct.
217
00:09:18,901 --> 00:09:23,262
I'd run a stereotactic MRI
with fiducials and DTI
218
00:09:23,286 --> 00:09:26,264
to gauge how close the white
matter tracts actually are.
219
00:09:27,523 --> 00:09:28,600
You should scrub in.
220
00:09:28,624 --> 00:09:30,269
(CHUCKLES)
221
00:09:30,293 --> 00:09:32,103
Another doctor can cover the clinic.
222
00:09:33,396 --> 00:09:36,299
I haven't been in an OR in over a year,
223
00:09:36,323 --> 00:09:38,358
and then, as a patient.
224
00:09:38,382 --> 00:09:40,446
I'm not asking you to cut.
225
00:09:40,470 --> 00:09:42,771
But it'd be a huge value
to have you there.
226
00:09:43,156 --> 00:09:44,850
(CHUCKLES SOFTLY)
227
00:09:44,874 --> 00:09:46,585
I appreciate that.
228
00:09:46,609 --> 00:09:47,953
I'll consider it.
229
00:09:47,977 --> 00:09:50,379
♪
230
00:09:55,418 --> 00:09:57,396
(DOOR OPENS)
231
00:09:57,420 --> 00:09:59,054
(DOOR CLOSES)
232
00:10:02,392 --> 00:10:05,437
Hello. We need to run cytology
on this lymphatic fluid.
233
00:10:05,461 --> 00:10:07,430
I would be happy to.
234
00:10:11,334 --> 00:10:13,228
Lea moved out this morning.
235
00:10:16,139 --> 00:10:18,083
- Thank you.
- You're welcome.
236
00:10:18,107 --> 00:10:19,985
Can you come over tonight?
237
00:10:20,009 --> 00:10:21,787
Uh, that probably won't work...
238
00:10:21,811 --> 00:10:23,405
Or we could go to your apartment?
239
00:10:24,814 --> 00:10:26,116
I can't.
240
00:10:28,184 --> 00:10:30,662
Lea said that it might take time
241
00:10:30,686 --> 00:10:32,631
for us to recover from our fight.
242
00:10:32,655 --> 00:10:34,400
But I told her that we were okay.
243
00:10:34,424 --> 00:10:36,526
We are.
244
00:10:36,550 --> 00:10:38,319
I made plans tonight.
245
00:10:38,343 --> 00:10:41,464
To hang out with a friend
who just got fired.
246
00:10:41,864 --> 00:10:44,217
But I would love to come over
tomorrow night.
247
00:10:44,700 --> 00:10:46,678
Okay.
248
00:10:46,702 --> 00:10:48,639
I'll put a rush on this test, too.
249
00:10:48,663 --> 00:10:50,830
♪
250
00:10:56,612 --> 00:10:59,324
Your lymphovenous
anastomosis technique...
251
00:10:59,348 --> 00:11:01,326
I was impressed.
252
00:11:01,350 --> 00:11:02,795
It's a little early in the morning
253
00:11:02,819 --> 00:11:04,177
to be sucking up, Reznick.
254
00:11:04,201 --> 00:11:06,365
Not for me.
I like to get a jump on things.
255
00:11:06,389 --> 00:11:08,667
I'm fascinated by the way
you use plastic procedures,
256
00:11:08,691 --> 00:11:11,561
like microsurgery,
in other surgical specialties.
257
00:11:11,585 --> 00:11:13,913
I thought it might make an
interesting topic for a paper.
258
00:11:14,530 --> 00:11:15,797
Want to write it with me?
259
00:11:17,400 --> 00:11:18,510
Yes.
260
00:11:18,534 --> 00:11:19,701
Let's talk and eat.
261
00:11:22,872 --> 00:11:24,172
That's not breakfast.
262
00:11:25,675 --> 00:11:27,352
I'm buying.
263
00:11:27,376 --> 00:11:29,488
What publications do you want to target?
264
00:11:29,512 --> 00:11:30,745
(SIGHS)
265
00:11:32,215 --> 00:11:34,417
Last time, Angie had
bad post-op vomiting.
266
00:11:34,441 --> 00:11:35,707
- Of course. I'll make note of it...
- Excuse me.
267
00:11:37,487 --> 00:11:40,466
She's asleep. She needs her rest.
268
00:11:40,490 --> 00:11:42,067
I'll wait out here until she's awake.
269
00:11:42,091 --> 00:11:44,002
Ryan, your immune system is weak.
270
00:11:44,026 --> 00:11:47,072
It would be so easy for you to
pick up a bug and pass it to Angie.
271
00:11:47,096 --> 00:11:49,007
I haven't been around
anyone but my dad. I swear.
272
00:11:49,031 --> 00:11:50,700
He could wear a mask.
273
00:11:55,004 --> 00:11:58,143
After Angie's surgery,
we'll see about arranging a visit.
274
00:11:58,167 --> 00:11:59,709
Please tell her Ryan came by.
275
00:12:02,945 --> 00:12:04,923
I'm sorry if I overstepped.
276
00:12:05,615 --> 00:12:07,226
I'd like to change Angie's status
277
00:12:07,250 --> 00:12:08,594
to "No visitors" on her chart.
278
00:12:08,618 --> 00:12:09,785
Yeah.
279
00:12:09,809 --> 00:12:11,977
♪
280
00:12:17,426 --> 00:12:18,871
Please take Mr. McDougall to his room.
281
00:12:18,895 --> 00:12:20,313
I'll be there in a moment.
282
00:12:22,365 --> 00:12:24,150
Is that James McDougall?
283
00:12:24,967 --> 00:12:26,778
- And the woman with him?
- His wife.
284
00:12:26,802 --> 00:12:28,714
- Is it cancer?
- (SIGHS)
285
00:12:28,738 --> 00:12:31,016
No... Worse.
286
00:12:31,040 --> 00:12:34,453
His lymphedema is caused
by a genetic mutation.
287
00:12:34,477 --> 00:12:36,922
If you don't find a
medication he responds to,
288
00:12:36,946 --> 00:12:39,291
he'll drown from the inside.
289
00:12:39,315 --> 00:12:41,082
♪
290
00:12:43,770 --> 00:12:46,582
The mutation is on James' ARAF gene...
291
00:12:46,606 --> 00:12:48,479
It makes an enzyme called kinase,
292
00:12:48,503 --> 00:12:50,686
which can cause cells to overproliferate.
293
00:12:50,710 --> 00:12:52,552
It's a genetic condition.
294
00:12:53,980 --> 00:12:55,622
What set it off now?
295
00:12:55,646 --> 00:12:57,089
Probably the stress fracture.
296
00:12:57,113 --> 00:12:58,661
Sent his immune system into overdrive,
297
00:12:58,685 --> 00:13:00,268
which fired up his lymphatic system.
298
00:13:01,128 --> 00:13:02,932
What treatment protocol
targets this mutation?
299
00:13:02,956 --> 00:13:04,867
An MEK inhibitor.
300
00:13:04,891 --> 00:13:06,352
The problem is, which one?
301
00:13:06,376 --> 00:13:09,694
There are 41 possibilities,
each with different side effects.
302
00:13:10,563 --> 00:13:11,697
Good luck.
303
00:13:12,196 --> 00:13:14,157
Well, I was hoping you could stay.
304
00:13:17,871 --> 00:13:19,871
Okay. Sure.
305
00:13:21,388 --> 00:13:22,522
(MRI MACHINE HUMMING)
306
00:13:22,546 --> 00:13:24,375
We need you to stay completely still.
307
00:13:25,718 --> 00:13:26,961
Not a problem.
308
00:13:28,848 --> 00:13:29,915
You okay?
309
00:13:31,217 --> 00:13:33,062
Ryan totally bailed.
310
00:13:33,086 --> 00:13:34,468
He hasn't come back to see me.
311
00:13:37,817 --> 00:13:39,653
If you tell her that her mom
said he couldn't visit,
312
00:13:39,677 --> 00:13:41,137
she'll be pissed at her mom.
313
00:13:41,161 --> 00:13:42,476
How's that gonna help?
314
00:13:44,998 --> 00:13:47,607
He's probably busy catching up in school.
315
00:13:50,837 --> 00:13:52,748
We had a pact.
316
00:13:52,772 --> 00:13:55,489
As long as we were together,
cancer wasn't gonna beat us.
317
00:13:56,710 --> 00:13:58,487
He broke it.
318
00:13:58,511 --> 00:13:59,855
Cancer wins.
319
00:13:59,879 --> 00:14:02,247
♪
320
00:14:05,303 --> 00:14:06,471
Do you mind finishing?
321
00:14:06,495 --> 00:14:08,029
(SIGHS)
322
00:14:10,690 --> 00:14:13,125
♪
323
00:14:18,732 --> 00:14:19,775
Imaging finished?
324
00:14:19,799 --> 00:14:21,177
Not quite.
325
00:14:21,201 --> 00:14:25,181
Mrs. Valens, Angie would
really like to see Ryan.
326
00:14:25,205 --> 00:14:26,949
I know you're concerned about infection,
327
00:14:26,973 --> 00:14:28,308
but there is minimal risk.
328
00:14:28,332 --> 00:14:31,317
Actually... Actually, none,
if they do a video chat.
329
00:14:32,212 --> 00:14:33,756
Interesting idea.
330
00:14:33,780 --> 00:14:35,029
I'll think about it.
331
00:14:37,784 --> 00:14:39,586
Angie's depressed.
332
00:14:39,610 --> 00:14:42,131
And studies have shown that
that can have a negative impact
333
00:14:42,155 --> 00:14:43,663
on her surgical outcome.
334
00:14:44,724 --> 00:14:46,736
(LAUGHS)
335
00:14:46,760 --> 00:14:50,306
Ryan doesn't always improve Angie's mood.
336
00:14:50,330 --> 00:14:52,665
A couple of weeks ago,
they had some silly fight,
337
00:14:52,689 --> 00:14:55,111
and she cried for days.
338
00:14:55,135 --> 00:14:56,879
Thank you for letting me know.
339
00:14:56,903 --> 00:14:58,414
I'm gonna do my best to cheer her up.
340
00:14:58,438 --> 00:15:00,416
She's a 16-year-old.
341
00:15:00,440 --> 00:15:01,817
She wants her boyfriend.
342
00:15:01,841 --> 00:15:03,486
Yeah.
343
00:15:03,510 --> 00:15:05,434
And how smart were you when you were 16?
344
00:15:13,019 --> 00:15:14,930
DR. REZNICK: Well,
what about Selumetinib?
345
00:15:14,954 --> 00:15:17,666
It's shown promising results
on related conditions.
346
00:15:17,690 --> 00:15:20,302
And a high occurrence of liver disease.
347
00:15:20,326 --> 00:15:23,995
Binimetinib is similar,
but has fewer complications.
348
00:15:24,764 --> 00:15:26,247
Any objections?
349
00:15:29,035 --> 00:15:30,376
Let's start James on that.
350
00:15:34,941 --> 00:15:35,974
(DOOR OPENS)
351
00:15:38,878 --> 00:15:41,957
This is exciting, working together.
352
00:15:41,981 --> 00:15:43,606
It is.
353
00:15:43,630 --> 00:15:48,185
Although, I'm used to samples
and slides instead of patients.
354
00:15:52,025 --> 00:15:54,804
Patients can be difficult.
355
00:15:54,828 --> 00:15:56,277
But you will be fine.
356
00:16:06,372 --> 00:16:09,174
♪
357
00:16:15,515 --> 00:16:16,682
Do you need something?
358
00:16:17,584 --> 00:16:19,061
(SIGHS)
359
00:16:19,085 --> 00:16:22,298
I was curious how James was
responding to the Binimetinib.
360
00:16:22,322 --> 00:16:23,532
His urine output is up,
361
00:16:23,556 --> 00:16:26,140
which suggests the lymphatic fluid...
362
00:16:27,160 --> 00:16:28,704
And his potassium is a little low.
363
00:16:28,728 --> 00:16:30,263
Can you... give him this?
364
00:16:30,287 --> 00:16:31,307
I wasn't really...
365
00:16:31,331 --> 00:16:33,899
♪
366
00:16:48,181 --> 00:16:49,258
Hi.
367
00:16:49,282 --> 00:16:51,026
I'm Dr. Lever.
368
00:16:51,050 --> 00:16:52,952
The tumor's abutting
and possibly infiltrating
369
00:16:52,976 --> 00:16:54,711
the white matter tracts of her fornix.
370
00:16:54,735 --> 00:16:56,565
We'll likely have to remove a section.
371
00:16:56,589 --> 00:16:59,001
That'll affect her ability
to form memories.
372
00:16:59,025 --> 00:17:00,369
With a lot of neuropsych rehab,
373
00:17:00,393 --> 00:17:03,131
she may be able to compensate
with other pathways.
374
00:17:03,155 --> 00:17:06,541
Studies have shown that positive
attitudes lead to positive outcomes.
375
00:17:06,565 --> 00:17:07,666
You're worried about her attitude?
376
00:17:07,690 --> 00:17:09,091
She's worried about young love.
377
00:17:09,115 --> 00:17:11,217
I'm worried about what Angie
is facing after surgery.
378
00:17:11,241 --> 00:17:13,610
Physical therapy, cognitive therapy,
379
00:17:13,634 --> 00:17:15,069
one challenge after another.
380
00:17:15,093 --> 00:17:16,732
And what she wants is so simple.
381
00:17:19,212 --> 00:17:20,694
You want to make a sad kid happy?
382
00:17:22,454 --> 00:17:23,622
I guess I do.
383
00:17:23,646 --> 00:17:25,447
Which isn't my job, and I need to stop
384
00:17:25,471 --> 00:17:26,939
getting sucked into
people's personal issues.
385
00:17:26,963 --> 00:17:29,245
Is there a way to do that
without antagonizing the mother?
386
00:17:33,159 --> 00:17:34,570
Maybe.
387
00:17:34,594 --> 00:17:35,662
(ELEVATOR BELL DINGS)
388
00:17:35,686 --> 00:17:36,961
Then make her happy.
389
00:17:41,234 --> 00:17:42,978
(BOTH BREATHING HEAVILY)
390
00:17:43,002 --> 00:17:45,837
♪
391
00:17:46,973 --> 00:17:48,340
(GIGGLES)
392
00:17:54,180 --> 00:17:56,759
We've never gotten this far before.
393
00:17:56,783 --> 00:17:57,927
No.
394
00:17:57,951 --> 00:17:59,561
We haven't.
395
00:17:59,585 --> 00:18:00,619
And you're okay?
396
00:18:02,088 --> 00:18:03,612
I am very okay.
397
00:18:12,298 --> 00:18:13,442
(GASPS)
398
00:18:13,466 --> 00:18:14,510
Carly.
399
00:18:14,534 --> 00:18:16,111
Ohh.
400
00:18:16,135 --> 00:18:17,536
(LAUGHS)
401
00:18:29,682 --> 00:18:30,782
Okay.
402
00:18:37,957 --> 00:18:40,859
Did... I do something wrong?
403
00:18:42,128 --> 00:18:44,069
No, I'm sorry. It's me.
404
00:18:45,298 --> 00:18:48,777
You said we were okay.
405
00:18:48,801 --> 00:18:50,179
I thought we were.
406
00:18:50,203 --> 00:18:51,380
I-I want us to be.
407
00:18:51,404 --> 00:18:53,482
You have no reason to still be mad.
408
00:18:53,506 --> 00:18:54,783
I'm not mad.
409
00:18:54,807 --> 00:18:56,151
I'm... I'm just...
410
00:18:56,175 --> 00:18:58,043
(CELL PHONE BEEPING)
411
00:19:02,641 --> 00:19:03,842
It's Morgan.
412
00:19:03,866 --> 00:19:07,170
The medication caused James
an upper GI bleed.
413
00:19:07,194 --> 00:19:09,963
♪
414
00:19:15,812 --> 00:19:17,457
Have you localized
the source of the bleeding?
415
00:19:17,481 --> 00:19:18,698
Working on it.
416
00:19:18,722 --> 00:19:20,994
Seems to be coming from
the antrum of the stomach.
417
00:19:21,018 --> 00:19:22,854
DR. REZNICK: We stopped the Binimetinib.
418
00:19:22,878 --> 00:19:25,298
On top of causing this, it hadn't
done much to curtail the swelling.
419
00:19:25,322 --> 00:19:26,699
Where's Dr. Lever?
420
00:19:26,723 --> 00:19:28,659
DR. ANDREWS: There's the
ulcerative lesion. Cautery.
421
00:19:31,895 --> 00:19:33,806
Zebrafish.
422
00:19:33,830 --> 00:19:35,041
They're used in medical research
423
00:19:35,065 --> 00:19:36,566
because of their quick maturation,
424
00:19:36,590 --> 00:19:39,360
and 84% of genes associated
with human disease
425
00:19:39,384 --> 00:19:41,219
have a zebrafish equivalent.
426
00:19:41,243 --> 00:19:44,613
You think we should do
a transgenic expression
427
00:19:44,637 --> 00:19:48,740
of James' ARAF mutation
into the zebrafish genome.
428
00:19:48,764 --> 00:19:50,023
Translation for those of us
429
00:19:50,047 --> 00:19:51,858
without a genetics textbook handy?
430
00:19:51,882 --> 00:19:54,193
We make mini-Jameses, as zebrafish,
431
00:19:54,217 --> 00:19:55,752
all with the same disorder.
432
00:19:55,776 --> 00:19:58,965
Then we test every conceivable
drug on those fish.
433
00:19:58,989 --> 00:20:00,500
How long before we can start testing?
434
00:20:00,524 --> 00:20:02,168
If we implant the embryos now,
435
00:20:02,192 --> 00:20:03,970
probably by late afternoon tomorrow.
436
00:20:03,994 --> 00:20:05,159
Get going.
437
00:20:05,183 --> 00:20:07,240
Shaun, go with her.
You have Path experience.
438
00:20:07,264 --> 00:20:09,375
♪
439
00:20:09,399 --> 00:20:11,100
(DOOR OPENS)
440
00:20:28,418 --> 00:20:31,597
I understand no means no.
441
00:20:31,621 --> 00:20:35,057
If you don't want to have sex,
442
00:20:35,459 --> 00:20:37,126
I accept that.
443
00:20:37,413 --> 00:20:39,796
But I am very confused.
444
00:20:40,130 --> 00:20:42,075
So am I.
445
00:20:42,099 --> 00:20:44,177
I thought I was fine u-until I...
446
00:20:44,201 --> 00:20:48,247
I told Lea to move out, like you wanted.
447
00:20:48,271 --> 00:20:51,391
You said that things were okay.
448
00:20:51,775 --> 00:20:54,436
They aren't. How do I make them okay?
449
00:20:55,278 --> 00:20:57,689
I can't tell you, because I don't know.
450
00:20:58,882 --> 00:21:02,118
♪
451
00:21:22,239 --> 00:21:23,673
When I was in chemo,
452
00:21:23,697 --> 00:21:25,966
the nurses used to force
that stuff down my throat,
453
00:21:25,990 --> 00:21:28,588
so I know you're not drinking
it because of the taste.
454
00:21:28,612 --> 00:21:29,789
(CHUCKLES LIGHTLY)
455
00:21:29,813 --> 00:21:31,457
It's fast, easy nutrition.
456
00:21:31,481 --> 00:21:34,434
That and you don't end up puking
your guts out in the bathroom.
457
00:21:36,045 --> 00:21:38,581
I was president of this
hospital for over 10 years.
458
00:21:38,605 --> 00:21:41,275
I made a few friends,
including Jack the janitor...
459
00:21:41,299 --> 00:21:44,403
Talks a lot, A's fan, horrible gossip.
460
00:21:44,427 --> 00:21:46,863
If the methotrexate is making you sick,
461
00:21:46,887 --> 00:21:48,573
we should try another medication.
462
00:21:51,367 --> 00:21:53,970
How can you guarantee
that you're not gonna throw up
463
00:21:53,994 --> 00:21:55,594
in the middle of your next surgery?
464
00:21:56,458 --> 00:21:57,859
It won't happen.
465
00:21:59,276 --> 00:22:01,788
Because it only happens
if I eat solid food.
466
00:22:01,812 --> 00:22:03,296
And I stopped.
467
00:22:04,606 --> 00:22:05,873
At least at work.
468
00:22:13,102 --> 00:22:15,403
♪
469
00:22:17,661 --> 00:22:20,206
That is a lot of fish tanks.
470
00:22:20,230 --> 00:22:25,201
Forty. So we can test all of
the possible medications for...
471
00:22:25,458 --> 00:22:27,026
Are you throwing a party?
472
00:22:27,050 --> 00:22:28,216
Hope so.
473
00:22:41,051 --> 00:22:42,218
How are you doing, Shaun?
474
00:22:43,687 --> 00:22:45,422
Since your father passed away?
475
00:22:47,691 --> 00:22:51,678
I don't think about him very much.
476
00:22:56,066 --> 00:22:59,212
My mom... died recently.
477
00:22:59,236 --> 00:23:01,229
I-I don't know if you knew that.
478
00:23:02,873 --> 00:23:05,317
She pops into my head all the time.
479
00:23:07,210 --> 00:23:09,237
Not always the nicest thoughts.
480
00:23:15,852 --> 00:23:19,706
It's okay not to love them.
481
00:23:21,725 --> 00:23:23,226
They didn't make us who we are.
482
00:23:23,250 --> 00:23:25,685
♪
483
00:23:42,612 --> 00:23:45,247
♪
484
00:24:00,430 --> 00:24:01,964
Has your mom gone home?
485
00:24:04,560 --> 00:24:07,697
There is one more thing
we have to deal with tonight.
486
00:24:07,721 --> 00:24:09,382
(SCOFFS)
487
00:24:09,406 --> 00:24:10,917
Come on.
488
00:24:10,941 --> 00:24:13,385
How many more sets of imaging
can you possibly do?
489
00:24:15,245 --> 00:24:18,124
One of these is your prom dress.
490
00:24:18,148 --> 00:24:21,894
I like the pink, but I think
you'd look gorgeous in both.
491
00:24:21,918 --> 00:24:23,852
♪
492
00:24:25,622 --> 00:24:27,066
Hurry up and choose.
493
00:24:27,090 --> 00:24:28,650
Your date'll be here soon.
494
00:24:30,460 --> 00:24:32,094
(LAUGHS)
495
00:24:41,972 --> 00:24:43,915
All the medications are in.
496
00:24:44,658 --> 00:24:48,654
Which means more waiting
to see which medicine works.
497
00:24:48,678 --> 00:24:50,297
It's hard to be patient.
498
00:24:55,885 --> 00:24:59,598
Do you think the fish control
how they react to the meds?
499
00:25:00,056 --> 00:25:01,123
No.
500
00:25:02,459 --> 00:25:04,811
It's just how their bodies respond.
501
00:25:07,477 --> 00:25:09,482
That's how I felt last night.
502
00:25:12,068 --> 00:25:14,697
I thought I was ready
for us to be together,
503
00:25:14,721 --> 00:25:18,617
but my body had a different response.
504
00:25:20,844 --> 00:25:22,521
I can't turn that response off
505
00:25:22,545 --> 00:25:24,390
any more than these fish can control
506
00:25:24,414 --> 00:25:27,159
how their mutation reacts
to the medication.
507
00:25:27,183 --> 00:25:29,218
♪
508
00:25:33,423 --> 00:25:35,634
Was our mutation
509
00:25:35,658 --> 00:25:38,511
me going to Wyoming with Lea?
510
00:25:45,268 --> 00:25:49,439
Do you think we can find
our right medication?
511
00:26:02,719 --> 00:26:05,931
♪ I found a love ♪
512
00:26:05,955 --> 00:26:08,501
♪ For me ♪
513
00:26:08,525 --> 00:26:10,269
♪
514
00:26:10,293 --> 00:26:14,006
♪ Darling, just dive right in ♪
515
00:26:14,030 --> 00:26:16,131
♪ Follow my lead ♪
516
00:26:18,034 --> 00:26:21,414
♪ I found a girl ♪
517
00:26:21,438 --> 00:26:23,716
♪ Beautiful and sweet ♪
518
00:26:23,740 --> 00:26:25,584
You look amazing.
519
00:26:25,608 --> 00:26:30,556
♪ I never knew you were
the someone waiting for me ♪
520
00:26:30,580 --> 00:26:32,058
So do you.
521
00:26:32,082 --> 00:26:36,729
♪ 'Cause we were just kids
when we fell in love ♪
522
00:26:36,753 --> 00:26:40,800
♪ Not knowing what it was ♪
523
00:26:40,824 --> 00:26:47,740
♪ I will not give you up this time ♪
524
00:26:47,764 --> 00:26:51,811
♪ Darling, just kiss me slow ♪
525
00:26:51,835 --> 00:26:56,082
♪ Your heart is all I own ♪
526
00:26:56,106 --> 00:27:02,288
♪ And in your eyes, you're holding mine ♪
527
00:27:02,312 --> 00:27:06,058
♪ Baby, I'm ♪
528
00:27:06,082 --> 00:27:09,728
♪ Dancing in the dark ♪
529
00:27:09,752 --> 00:27:13,933
♪ With you between my arms ♪
530
00:27:13,957 --> 00:27:17,570
♪ Barefoot on the grass ♪
531
00:27:17,594 --> 00:27:21,030
♪ Listening to our favorite song ♪
532
00:27:21,054 --> 00:27:24,424
♪ When you said you looked a mess ♪
533
00:27:24,448 --> 00:27:27,847
♪ I whispered underneath my breath ♪
534
00:27:27,871 --> 00:27:29,148
Looks like you might be feeling
535
00:27:29,172 --> 00:27:31,784
a little idiotic happiness right now.
536
00:27:31,808 --> 00:27:33,285
Mm...
537
00:27:33,309 --> 00:27:35,154
Maybe a touch.
538
00:27:35,178 --> 00:27:37,679
♪
539
00:27:40,483 --> 00:27:42,261
♪ No, no ♪
540
00:27:42,285 --> 00:27:44,263
Dance with a prom king?
541
00:27:44,287 --> 00:27:46,332
Ohh. (LAUGHS)
542
00:27:46,356 --> 00:27:49,635
♪ You look perfect tonight ♪
543
00:27:49,659 --> 00:27:51,704
(LAUGHS)
544
00:27:51,728 --> 00:27:55,030
♪
545
00:28:02,839 --> 00:28:04,072
- (MONITOR BEEPING RAPIDLY)
- He's tachycardic.
546
00:28:06,509 --> 00:28:08,053
We were talking,
and then he just stopped.
547
00:28:08,077 --> 00:28:09,388
We need to do a pericardial tap.
548
00:28:09,412 --> 00:28:11,357
Call the cath lab.
Tell them we're coming.
549
00:28:11,381 --> 00:28:12,791
No time. We're doing it here.
550
00:28:12,815 --> 00:28:14,059
James, the pain in your chest
551
00:28:14,083 --> 00:28:15,661
is from too much fluid around your heart.
552
00:28:15,685 --> 00:28:17,463
We're gonna put a tube
into your chest to drain it.
553
00:28:17,487 --> 00:28:18,987
Call Shaun and Carly.
Tell them we're running out of time.
554
00:28:23,159 --> 00:28:28,674
♪ ...will be loving you till we're 70 ♪
555
00:28:28,698 --> 00:28:31,333
(CAMERA SHUTTER CLICKING)
556
00:28:33,436 --> 00:28:40,108
♪ And, baby, my heart could
still fall as hard at 23 ♪
557
00:28:43,546 --> 00:28:46,192
♪ And I'm thinking about how ♪
558
00:28:46,216 --> 00:28:51,397
♪ People fall in love
in mysterious ways ♪
559
00:28:51,421 --> 00:28:52,998
I brought Angie's Bearfeet Bear.
560
00:28:53,022 --> 00:28:54,791
It always makes her feel like sh...
561
00:28:58,394 --> 00:29:01,006
It's... prom.
562
00:29:01,030 --> 00:29:03,198
Ryan has been wearing his mask all night.
563
00:29:04,801 --> 00:29:09,281
♪ And I just want to tell you I am ♪
564
00:29:09,305 --> 00:29:12,107
♪ So, honey, now ♪
565
00:29:14,744 --> 00:29:17,479
♪ Take me into your loving arms ♪
566
00:29:18,982 --> 00:29:20,893
Don't let her stay up too late.
567
00:29:20,917 --> 00:29:25,120
♪ Kiss me under the light
of a thousand stars ♪
568
00:29:27,056 --> 00:29:29,591
♪ Place your hand on my beating heart ♪
569
00:29:31,928 --> 00:29:33,795
(FOOTSTEPS APPROACH)
570
00:29:35,832 --> 00:29:38,793
Morgan called. James isn't doing well.
571
00:29:44,774 --> 00:29:47,594
Cross SL-327 off the list.
572
00:29:48,444 --> 00:29:50,956
I see one...
573
00:29:50,980 --> 00:29:54,056
No, two tumors.
574
00:29:54,080 --> 00:29:56,084
♪
575
00:30:17,129 --> 00:30:18,231
Okay.
576
00:30:18,703 --> 00:30:20,415
This is my stop.
577
00:30:20,440 --> 00:30:22,184
I'll see you after.
578
00:30:22,209 --> 00:30:23,686
I love you.
579
00:30:23,711 --> 00:30:25,012
I love you, too, Mom.
580
00:30:28,760 --> 00:30:30,772
Don't worry. Okay?
581
00:30:30,996 --> 00:30:32,196
I got this.
582
00:30:34,747 --> 00:30:36,481
I know you do.
583
00:30:36,982 --> 00:30:38,693
(CHUCKLES)
584
00:30:38,717 --> 00:30:40,451
♪
585
00:30:42,988 --> 00:30:44,366
(CHUCKLES)
586
00:30:44,390 --> 00:30:45,467
Okay.
587
00:30:45,491 --> 00:30:46,535
Okay.
588
00:30:46,559 --> 00:30:48,893
♪
589
00:30:51,943 --> 00:30:56,128
What if I wake up and
don't remember Ryan at all?
590
00:30:59,738 --> 00:31:00,939
Then...
591
00:31:02,274 --> 00:31:05,011
You'll have the chance to fall
in love with him all over again.
592
00:31:09,748 --> 00:31:10,848
Okay.
593
00:31:12,384 --> 00:31:13,528
Okay.
594
00:31:13,553 --> 00:31:14,763
(BREATHES SHAKILY)
595
00:31:14,788 --> 00:31:16,890
♪
596
00:31:24,483 --> 00:31:26,670
We're down to five potential options.
597
00:31:26,695 --> 00:31:29,074
I don't need five potential.
I need one actual.
598
00:31:29,098 --> 00:31:30,775
There are two that best curb...
599
00:31:30,799 --> 00:31:31,766
Choose one.
600
00:31:32,901 --> 00:31:36,881
We should try Refametinib.
601
00:31:36,905 --> 00:31:38,717
It caused abnormal cell growth.
602
00:31:38,741 --> 00:31:40,046
Trametinib is safer.
603
00:31:40,876 --> 00:31:42,253
Which doesn't mean it's safe.
604
00:31:42,277 --> 00:31:43,588
Nothing's safe.
605
00:31:43,612 --> 00:31:44,718
Which do you want us to do?
606
00:31:46,882 --> 00:31:47,982
(SIGHS)
607
00:31:49,218 --> 00:31:50,528
Trametinib.
608
00:31:50,552 --> 00:31:52,197
That's the one.
609
00:31:52,221 --> 00:31:54,555
♪
610
00:31:57,993 --> 00:31:59,494
Saline in.
611
00:31:59,518 --> 00:32:02,140
Advancing scope
toward the third ventricle.
612
00:32:02,164 --> 00:32:04,109
Claire, hold gentle pressure on the tumor
613
00:32:04,133 --> 00:32:05,877
while I cut off its blood supply.
614
00:32:05,901 --> 00:32:07,969
(MONITORS BEEPING STEADILY)
615
00:32:12,574 --> 00:32:14,252
We've got some significant bleeding.
616
00:32:14,276 --> 00:32:15,874
Adjust the scope and suction.
617
00:32:20,783 --> 00:32:22,214
Look higher.
618
00:32:23,252 --> 00:32:24,729
Septal vein... There's your bleeder.
619
00:32:24,753 --> 00:32:26,176
Cauterize away.
620
00:32:38,300 --> 00:32:40,334
♪
621
00:33:11,400 --> 00:33:12,764
DR. MELENDEZ: Micro dissector.
622
00:33:17,873 --> 00:33:19,714
The tumor's immobile.
623
00:33:19,738 --> 00:33:21,786
I can't resect it without
injuring the nerve tracts.
624
00:33:21,810 --> 00:33:23,555
She'd be comatose.
625
00:33:23,579 --> 00:33:24,943
Try sharp dissection.
626
00:33:26,715 --> 00:33:28,327
- DR. MELENDEZ: I can't get a plane.
- DR. GLASSMAN: How bad?
627
00:33:28,351 --> 00:33:30,228
DR. MELENDEZ: It's completely
invaded her thalamus.
628
00:33:30,252 --> 00:33:33,827
Thin it out with a suction aspirator.
629
00:33:39,728 --> 00:33:41,239
DR. MELENDEZ: It's too adherent.
630
00:33:41,263 --> 00:33:43,003
If I keep going, I'm gonna kill her.
631
00:33:45,167 --> 00:33:46,367
Any ideas?
632
00:33:50,072 --> 00:33:52,406
♪
633
00:34:08,517 --> 00:34:12,032
Tell ICU Angie will be coming
sooner than we planned.
634
00:34:13,562 --> 00:34:14,929
Let's close her up.
635
00:34:34,573 --> 00:34:36,017
What's next?
636
00:34:36,041 --> 00:34:38,319
Another round of radiation, chemo?
637
00:34:41,313 --> 00:34:44,002
Her carcinoma is
638
00:34:44,026 --> 00:34:46,703
unlikely to respond to those therapies.
639
00:34:50,355 --> 00:34:52,709
No. We have to try.
640
00:34:53,692 --> 00:34:55,036
Angie will want to fight.
641
00:34:55,060 --> 00:34:56,371
- (MONITOR BEEPING RAPIDLY)
- She's seizing.
642
00:34:56,395 --> 00:34:57,639
Give me lorazepam and Dilantin, stat.
643
00:34:57,663 --> 00:34:58,973
Phenobarb and propofol on deck.
644
00:34:58,997 --> 00:35:01,499
♪
645
00:35:21,954 --> 00:35:23,114
You're crying.
646
00:35:26,625 --> 00:35:27,702
Yes.
647
00:35:31,396 --> 00:35:32,563
Why?
648
00:35:35,234 --> 00:35:37,712
I found James on Facebook.
649
00:35:37,736 --> 00:35:39,347
(SNIFFLES)
650
00:35:39,371 --> 00:35:41,924
He and Marjorie want to go to Costa Rica.
651
00:35:43,775 --> 00:35:47,522
Their dog is a three-legged
rescue named Tripod.
652
00:35:47,546 --> 00:35:49,580
♪
653
00:35:52,117 --> 00:35:54,228
He's not a slide. He's a person.
654
00:35:55,621 --> 00:35:57,065
He's a good person.
655
00:35:57,089 --> 00:35:58,867
And he might die.
656
00:35:58,891 --> 00:36:00,535
(SNIFFLES)
657
00:36:00,559 --> 00:36:02,612
This is why I like to stay in the lab.
658
00:36:08,066 --> 00:36:09,661
That...
659
00:36:10,302 --> 00:36:12,955
Is a very dumb thing to say.
660
00:36:15,734 --> 00:36:18,252
If you had stayed in the lab,
661
00:36:18,510 --> 00:36:21,714
James would probably be dead already.
662
00:36:24,416 --> 00:36:29,631
Your plan with the
zebrafish gave him a chance.
663
00:36:29,655 --> 00:36:35,436
It was a beautiful, perfect idea,
664
00:36:35,460 --> 00:36:38,139
from a beautiful, almost perfect person.
665
00:36:38,163 --> 00:36:39,997
♪
666
00:36:44,269 --> 00:36:47,081
Your earlobes are lopsided.
667
00:36:47,105 --> 00:36:48,639
(CHUCKLES)
668
00:37:20,572 --> 00:37:22,817
I'm so sorry.
669
00:37:22,841 --> 00:37:24,519
We couldn't save her.
670
00:37:24,543 --> 00:37:26,721
(BREATHING RAGGEDLY)
671
00:37:26,745 --> 00:37:29,513
♪
672
00:37:36,321 --> 00:37:38,022
(CRYING)
673
00:37:45,197 --> 00:37:46,764
Ms. Valens?
674
00:38:19,344 --> 00:38:21,125
Nice call on the zebrafish.
675
00:38:23,769 --> 00:38:26,180
(INAUDIBLE)
676
00:38:26,204 --> 00:38:28,406
♪
677
00:38:40,706 --> 00:38:42,817
About our paper, let's meet weekly.
678
00:38:42,842 --> 00:38:45,487
I'm thinking lunch every
Tuesday in the cafeteria.
679
00:38:45,590 --> 00:38:46,757
Perfect.
680
00:38:54,833 --> 00:38:57,245
(KNOCK ON DOOR)
681
00:38:57,269 --> 00:38:59,705
I heard about Melendez's patient.
682
00:39:03,141 --> 00:39:04,175
Yeah.
683
00:39:14,186 --> 00:39:15,930
You were right.
684
00:39:15,954 --> 00:39:20,101
I should probably try
another medication for my RA.
685
00:39:21,793 --> 00:39:23,312
I need solid food.
686
00:39:35,307 --> 00:39:36,868
DR. MELENDEZ: Claire? Wait up.
687
00:39:38,176 --> 00:39:39,687
You okay?
688
00:39:39,711 --> 00:39:41,789
Fine. I'm just tired.
689
00:39:43,789 --> 00:39:46,034
You did an amazing thing for Angie.
690
00:39:46,059 --> 00:39:49,171
You gave her mother a memory
that she will have forever.
691
00:39:49,196 --> 00:39:51,090
Well, it won't make up
for the daughter she lost.
692
00:39:51,790 --> 00:39:52,834
You're angry.
693
00:39:52,858 --> 00:39:55,336
I'm not. I am sad.
694
00:39:55,360 --> 00:39:57,338
- Who are you angry at?
- I'm not.
695
00:39:57,362 --> 00:39:58,473
Are you angry at me and Glassman
696
00:39:58,497 --> 00:39:59,640
because we couldn't save her?
697
00:39:59,664 --> 00:40:01,375
- No!
- At Angie?
698
00:40:01,399 --> 00:40:03,667
No, you can't be mad
at someone for dying!
699
00:40:05,003 --> 00:40:06,981
That's not true. You know that.
700
00:40:07,005 --> 00:40:09,350
♪
701
00:40:09,374 --> 00:40:11,052
She was sick.
702
00:40:11,076 --> 00:40:13,321
And she was trying to get better.
703
00:40:13,345 --> 00:40:15,674
She failed and left you alone.
704
00:40:15,698 --> 00:40:19,327
After you'd spent a lifetime
trying to take care of her.
705
00:40:19,351 --> 00:40:21,287
You have every reason
to be mad at your mother.
706
00:40:22,994 --> 00:40:24,705
I hate feeling this way.
707
00:40:24,730 --> 00:40:26,608
My whole life, I've been angry at her,
708
00:40:26,633 --> 00:40:28,544
and now it will never change.
709
00:40:29,728 --> 00:40:31,297
I don't know how to stop.
710
00:40:35,200 --> 00:40:37,578
Therapy will help.
711
00:40:37,602 --> 00:40:38,903
Time will help.
712
00:40:41,293 --> 00:40:43,461
There is one other thing
that's worked for me.
713
00:40:44,276 --> 00:40:45,910
♪
714
00:40:51,049 --> 00:40:52,160
(KEYS CLACK)
715
00:40:52,184 --> 00:40:53,928
(GIGGLES)
716
00:40:53,952 --> 00:40:56,063
♪
717
00:40:56,087 --> 00:40:58,055
Did we fix our mutation?
718
00:41:02,060 --> 00:41:03,127
(LAUGHS)
719
00:41:11,703 --> 00:41:13,347
That the best you got?
720
00:41:13,371 --> 00:41:16,373
♪