1 00:00:10,520 --> 00:00:11,628 Oh! 2 00:00:16,849 --> 00:00:20,195 We can't both shower at the same time, Lea. 3 00:00:20,219 --> 00:00:22,964 One of us would block the stream of water for the other. 4 00:00:22,988 --> 00:00:25,433 Oh, Shaun, this is not for the purpose of cleanliness. 5 00:00:25,457 --> 00:00:28,126 This is for the purpose of having sex with you. 6 00:00:29,795 --> 00:00:31,540 Oh. 7 00:00:31,564 --> 00:00:33,108 N-No. No. 8 00:00:33,132 --> 00:00:35,777 It would be inconvenient, possibly dangerous. 9 00:00:35,801 --> 00:00:38,113 Soap might get into difficult places. 10 00:00:38,137 --> 00:00:39,714 If we leaned against the shower handle, 11 00:00:39,738 --> 00:00:40,782 we could scald ourselves. 12 00:00:40,806 --> 00:00:43,251 Bottles could be disarranged. 13 00:00:43,275 --> 00:00:45,086 It was just a thought. 14 00:00:45,110 --> 00:00:47,122 It was a bad thought. 15 00:00:47,146 --> 00:00:48,223 I'm surprised. 16 00:00:48,247 --> 00:00:49,847 You're such an intelligent person. 17 00:00:51,450 --> 00:00:54,095 I'll... reset your alarm. 18 00:00:57,823 --> 00:01:00,302 It's a three-day weekend and a full moon. 19 00:01:00,326 --> 00:01:01,836 People are gonna do stupid things. 20 00:01:01,860 --> 00:01:04,806 I'm asking everyone to take an extra trauma call in the E.R. 21 00:01:04,830 --> 00:01:06,942 Make yourselves available if you're needed. 22 00:01:06,966 --> 00:01:08,421 Questions? 23 00:01:08,968 --> 00:01:10,979 How'd you get the bruise? 24 00:01:11,003 --> 00:01:12,247 First casualty of the full moon. 25 00:01:12,271 --> 00:01:13,648 I smacked my head on a cupboard door 26 00:01:13,672 --> 00:01:15,150 when I was reaching for my coffee mug. 27 00:01:15,174 --> 00:01:16,351 Any other questions? 28 00:01:16,375 --> 00:01:19,521 Why is there a Subaru in your parking space? 29 00:01:19,545 --> 00:01:21,022 Because it's my car. 30 00:01:21,046 --> 00:01:22,057 You have a car? 31 00:01:22,081 --> 00:01:24,059 You're gonna be seeing a lot of it. I sold the Ducati. 32 00:01:24,083 --> 00:01:25,060 What? No. 33 00:01:25,084 --> 00:01:26,294 It just wasn't practical. 34 00:01:26,318 --> 00:01:27,529 Is it already gone? Because... 35 00:01:27,553 --> 00:01:29,998 A guy from Craigslist snatched it up. 36 00:01:30,022 --> 00:01:33,191 Any other questions... Not dealing with the bike? 37 00:01:34,893 --> 00:01:36,738 It wasn't that much of a bruise. 38 00:01:37,863 --> 00:01:40,241 But the doctor at the ski resort told us 39 00:01:40,265 --> 00:01:41,910 I might develop a hematoma? 40 00:01:41,934 --> 00:01:44,647 It's not unusual, but it'll need to be drained. 41 00:01:45,104 --> 00:01:48,049 I see you were treated for melanoma six years ago, 42 00:01:48,073 --> 00:01:50,118 and, more recently, breast cancer. 43 00:01:50,142 --> 00:01:51,653 Hence the ski trip. 44 00:01:51,677 --> 00:01:53,431 A celebration. 45 00:01:53,879 --> 00:01:56,057 One year cancer-free. Also five years cancer-free. 46 00:01:58,717 --> 00:02:02,731 I don't suppose a long needle will be involved in this? 47 00:02:02,755 --> 00:02:04,699 Your hematoma extends pretty deep, 48 00:02:04,723 --> 00:02:06,334 so the needle will have to be long. 49 00:02:06,358 --> 00:02:08,003 But it's over quickly. 50 00:02:08,027 --> 00:02:10,005 Sorry, I have to intervene before this deal goes south. 51 00:02:10,029 --> 00:02:11,949 You don't mind if I step out? 52 00:02:13,544 --> 00:02:16,289 Would you like us to wait for your husband to come back? 53 00:02:16,720 --> 00:02:17,830 No. 54 00:02:18,303 --> 00:02:19,547 Let's go ahead. 55 00:02:22,901 --> 00:02:25,092 How do you get frostbite in San Jose? 56 00:02:25,116 --> 00:02:26,421 Cryotherapy accident. 57 00:02:26,445 --> 00:02:28,323 I stayed in the booth a little too long. 58 00:02:28,347 --> 00:02:30,425 I was going to stand outside for the full three minutes, 59 00:02:30,449 --> 00:02:32,127 - but he said... - I said, "No need." 60 00:02:32,151 --> 00:02:33,995 I'd set the stopwatch on my phone... 61 00:02:34,019 --> 00:02:36,698 After which, my thoughts immediately drifted, and... 62 00:02:36,722 --> 00:02:38,667 I came back to find him frozen in carbonite. 63 00:02:39,650 --> 00:02:41,826 You know, I'm more worried about the fever. 64 00:02:41,850 --> 00:02:43,772 Was the cryotherapy meant to treat something? 65 00:02:43,796 --> 00:02:45,106 No. Routine self-care. 66 00:02:45,130 --> 00:02:47,308 We've made life extension part of our health regime... 67 00:02:47,332 --> 00:02:49,964 Supplements, meditation, exercise. 68 00:02:49,998 --> 00:02:51,976 Three of my gaming apps have gone viral. 69 00:02:52,000 --> 00:02:54,789 I'm lucky enough to afford basically whatever I want, 70 00:02:54,813 --> 00:02:56,885 so I spend it on my health. 71 00:02:56,918 --> 00:03:00,318 No, I figure fever, must be an infection. 72 00:03:00,346 --> 00:03:03,286 Well, I know that frostbite can make you vulnerable. 73 00:03:03,310 --> 00:03:08,209 It just... It didn't seem severe enough to... 74 00:03:08,233 --> 00:03:11,029 Oh, sorry. I feel a little queasy. 75 00:03:11,190 --> 00:03:12,267 Aah! 76 00:03:12,291 --> 00:03:13,334 Wyatt. 77 00:03:13,358 --> 00:03:14,402 Ow! 78 00:03:22,735 --> 00:03:24,512 I need a medical transport team, stat. 79 00:03:24,536 --> 00:03:26,748 Perforated bowel. He needs immediate surgery. 80 00:03:28,355 --> 00:03:36,355 Synced & corrected by -robtor- www.addic7ed.com 81 00:03:36,380 --> 00:03:38,696 No. No. Why do people hate wind farms? 82 00:03:38,720 --> 00:03:40,731 Everyone thinks they're noisy. 83 00:03:40,755 --> 00:03:42,366 This could make a turbine sound as quiet 84 00:03:42,390 --> 00:03:43,868 as a page turning in a library. 85 00:03:43,892 --> 00:03:45,336 That's not worth our investing in? 86 00:03:45,360 --> 00:03:46,904 Did you even look... Hold on. 87 00:03:46,928 --> 00:03:48,772 Anything I need to know? 88 00:03:48,796 --> 00:03:49,940 Hematoma's drained. 89 00:03:49,964 --> 00:03:51,842 We're sending a sample to Pathology... routine. 90 00:03:51,866 --> 00:03:53,210 Should have it back sometime tomorrow. 91 00:03:53,234 --> 00:03:55,069 - Thank you. - Mm-hmm. 92 00:03:55,637 --> 00:03:58,115 I couldn't help overhearing a little. 93 00:03:58,139 --> 00:03:59,974 Are you a venture capitalist? 94 00:04:01,009 --> 00:04:03,220 The only people who ask me if I'm a VC 95 00:04:03,244 --> 00:04:05,913 are people who want a VC to invest in their project. 96 00:04:07,668 --> 00:04:11,715 Maybe, after we get your wife healthy again, we could talk? 97 00:04:11,786 --> 00:04:12,763 Call whenever you're ready. 98 00:04:12,787 --> 00:04:14,498 My life is listening to ideas. 99 00:04:14,522 --> 00:04:16,033 If it's good, I'll run it by my two partners. 100 00:04:16,057 --> 00:04:17,083 If it's really good, 101 00:04:17,124 --> 00:04:19,326 we'll take a 30% equity position in your company. 102 00:04:21,663 --> 00:04:22,788 Yeah. 103 00:04:23,131 --> 00:04:25,365 Yeah, you're the one who wanted us to get into clean technology. 104 00:04:27,535 --> 00:04:29,469 I think I've been asked out on a date. 105 00:04:31,411 --> 00:04:32,622 Nice. 106 00:04:32,647 --> 00:04:33,757 No, I work with him. 107 00:04:33,782 --> 00:04:35,693 - Hasn't stopped you before. - I supervise him. 108 00:04:35,718 --> 00:04:36,762 Schedules can be changed. 109 00:04:36,787 --> 00:04:38,198 He's polyamorous. 110 00:04:39,102 --> 00:04:41,725 Unless he also texted you a ring, it's just a date. 111 00:04:41,749 --> 00:04:43,283 And you need to get out more. 112 00:04:44,652 --> 00:04:45,752 So do I. 113 00:04:51,626 --> 00:04:54,506 You want to take down the splenocolic ligament. 114 00:04:54,530 --> 00:04:57,509 Just don't nick the inferior mesenteric artery. 115 00:04:57,533 --> 00:05:01,347 I feel the I.M.A. under my finger. 116 00:05:01,371 --> 00:05:03,329 Placing the stapler. 117 00:05:03,806 --> 00:05:05,414 And cutting. 118 00:05:06,207 --> 00:05:07,486 I voted "approve." 119 00:05:10,414 --> 00:05:12,091 Disapprove. 120 00:05:12,115 --> 00:05:13,926 No opinion. 121 00:05:13,950 --> 00:05:14,927 There's a poll? 122 00:05:14,951 --> 00:05:17,329 Yes... About shower sex. 123 00:05:17,353 --> 00:05:20,065 I know it's wrong to discuss shower sex at work, 124 00:05:20,089 --> 00:05:21,767 so I did a poll instead. 125 00:05:21,791 --> 00:05:23,202 Much better. 126 00:05:23,226 --> 00:05:25,604 Dr. Murphy, do you really want people knowing the details 127 00:05:25,628 --> 00:05:26,805 of your personal life? 128 00:05:26,829 --> 00:05:30,342 You don't think they took it as an abstract question? 129 00:05:30,366 --> 00:05:33,197 No. We all take it as something that happened between you and Lea. 130 00:05:33,221 --> 00:05:34,580 And that there was a fight. 131 00:05:34,604 --> 00:05:36,115 Sometime before 8:00 a.m. today, 132 00:05:36,139 --> 00:05:38,340 which was when the poll was sent out. 133 00:05:39,876 --> 00:05:41,587 You are very astute. 134 00:05:41,611 --> 00:05:44,823 I'm seeing diffuse dilation of the large bowel here. 135 00:05:44,847 --> 00:05:46,163 Is that normal? 136 00:05:47,216 --> 00:05:49,750 Some calcified lesions. 137 00:05:50,620 --> 00:05:52,097 Wall's thin, too. 138 00:05:52,121 --> 00:05:53,265 Hirschsprung's. 139 00:05:53,289 --> 00:05:55,200 I thought Hirschsprung's was a disease only babies 140 00:05:55,224 --> 00:05:56,301 and young children got. 141 00:05:56,325 --> 00:05:57,591 It is. 142 00:05:58,261 --> 00:05:59,471 But he has it. 143 00:06:08,620 --> 00:06:10,224 We treated the Hirschsprung's 144 00:06:10,267 --> 00:06:12,438 by removing the dilated part of your colon. 145 00:06:12,462 --> 00:06:14,206 It won't impact your life, 146 00:06:14,230 --> 00:06:15,874 but we would like an explanation. 147 00:06:15,898 --> 00:06:17,242 Dr. Murphy doesn't mean 148 00:06:17,266 --> 00:06:18,877 we expect you to be a diagnostician. 149 00:06:18,901 --> 00:06:20,178 It's just... 150 00:06:20,202 --> 00:06:21,947 this was kind of singular. 151 00:06:21,971 --> 00:06:24,316 So, if you have any thoughts... 152 00:06:24,340 --> 00:06:27,609 Did anyone in your family suddenly develop these symptoms? 153 00:06:31,080 --> 00:06:35,026 I did something singular to myself about six months ago. 154 00:06:35,362 --> 00:06:37,796 I modified my genetic code. 155 00:06:37,820 --> 00:06:40,565 I did a CRISPR procedure under the guidance of some researchers 156 00:06:40,589 --> 00:06:41,967 I know in China through my work. 157 00:06:41,991 --> 00:06:43,735 They put together a series of cocktails. 158 00:06:43,759 --> 00:06:48,206 They FedExed them to be, and Sophie helped me inject them 159 00:06:48,230 --> 00:06:49,508 into my bone marrow. 160 00:06:49,532 --> 00:06:50,876 Why? 161 00:06:50,900 --> 00:06:52,277 If you know anything about CRISPR, 162 00:06:52,301 --> 00:06:54,379 you know how risky it is to tinker with your genome. 163 00:06:54,403 --> 00:06:57,126 You have no idea what problems you might let loose. 164 00:06:57,150 --> 00:06:59,751 I needed to optimize my telomerase activity. 165 00:06:59,775 --> 00:07:01,386 It's the enzyme responsible for correcting 166 00:07:01,410 --> 00:07:02,420 cell replication errors... 167 00:07:02,444 --> 00:07:03,588 Essentially, the cause of aging. 168 00:07:03,612 --> 00:07:04,856 You can't stop aging 169 00:07:04,880 --> 00:07:06,958 through changing your telomerase activity. 170 00:07:06,982 --> 00:07:10,629 You might extend your life a little, but exercise... 171 00:07:10,653 --> 00:07:12,097 It does the same thing. 172 00:07:12,121 --> 00:07:13,098 Much less risky. 173 00:07:13,122 --> 00:07:14,699 Your decision makes no sense. 174 00:07:14,723 --> 00:07:18,336 Extending my life by a few years is only my short-term goal. 175 00:07:18,360 --> 00:07:20,472 Look, you know how fast medicine is moving. 176 00:07:20,496 --> 00:07:22,374 The day isn't that far away when cloning 177 00:07:22,398 --> 00:07:25,410 will make transplants as easy as switching out a light socket. 178 00:07:25,434 --> 00:07:27,212 AI will start to make breakthroughs 179 00:07:27,236 --> 00:07:28,880 that we can't predict or understand. 180 00:07:28,904 --> 00:07:31,871 Medical knowledge will rise exponentially. 181 00:07:31,895 --> 00:07:34,653 There are babies born now who could live to see it, 182 00:07:34,677 --> 00:07:36,688 could live to be 1,000 years old. 183 00:07:36,712 --> 00:07:38,323 Maybe more. Maybe forever. 184 00:07:38,676 --> 00:07:40,959 Or at least, as long as they want to. 185 00:07:40,983 --> 00:07:43,395 So, our plan is to give my CRISPR a year 186 00:07:43,419 --> 00:07:45,463 to make sure the telomerase change works, 187 00:07:45,487 --> 00:07:47,855 and then we'll do her. 188 00:07:49,592 --> 00:07:51,580 We'll aspirate a sample of your bone marrow. 189 00:07:51,604 --> 00:07:53,838 See if we can figure out what the hell you did. 190 00:08:01,182 --> 00:08:02,293 Hey. 191 00:08:02,318 --> 00:08:06,598 Um... I don't think coffee's a good idea. 192 00:08:06,842 --> 00:08:08,653 Entire civilizations rely on it. 193 00:08:08,677 --> 00:08:10,755 But I don't think you're referring to the beverage itself. 194 00:08:10,779 --> 00:08:12,591 I don't think it's a good idea for first-years 195 00:08:12,615 --> 00:08:13,925 and fourth-years to go out. 196 00:08:13,949 --> 00:08:16,895 I am bound to supervise you at some point in the future, 197 00:08:16,919 --> 00:08:20,098 and it'd get complicated trying to change dates out, 198 00:08:20,122 --> 00:08:23,034 and the fact is... 199 00:08:23,058 --> 00:08:26,004 seeing somebody you work with rarely ends happily. 200 00:08:26,028 --> 00:08:28,139 So, I appreciate you thinking of me, but I... 201 00:08:28,163 --> 00:08:29,977 Oh, you thought it was a date. 202 00:08:31,400 --> 00:08:33,144 I'm still new here, and I thought it was 203 00:08:33,168 --> 00:08:35,774 a good opportunity to get to know each other. 204 00:08:36,472 --> 00:08:38,650 Coffee's perfect because you're asking 205 00:08:38,674 --> 00:08:41,419 the least amount of commitment from another human being. 206 00:08:41,443 --> 00:08:43,488 It's not even lunch. 207 00:08:43,512 --> 00:08:45,523 If it's still a "no," it's still a "no," 208 00:08:45,547 --> 00:08:47,911 but I'll let you re-think your answer. 209 00:08:54,176 --> 00:08:55,830 _ 210 00:08:55,864 --> 00:08:57,833 _ 211 00:09:01,318 --> 00:09:04,230 He only claimed it wasn't a date to save face. 212 00:09:04,255 --> 00:09:06,767 Or maybe I just assumed. 213 00:09:06,792 --> 00:09:08,069 But why did I assume? 214 00:09:08,094 --> 00:09:09,939 I don't think I'm some kind of narcissist 215 00:09:09,964 --> 00:09:13,176 who thinks every man wants to get close to me. 216 00:09:13,201 --> 00:09:16,714 Or we both assumed it's a date because it's a date. 217 00:09:16,739 --> 00:09:18,917 This is fun. I like being your bestie. 218 00:09:18,942 --> 00:09:20,253 Slumber party? 219 00:09:26,064 --> 00:09:29,043 I made a poll to test the popularity of shower sex. 220 00:09:29,067 --> 00:09:30,211 I heard. 221 00:09:30,235 --> 00:09:32,313 I fielded some questions about that. 222 00:09:32,337 --> 00:09:36,885 "Approve" has won, but don't get too excited, Lea. 223 00:09:36,909 --> 00:09:39,320 It's only 58-38, 224 00:09:39,344 --> 00:09:41,890 with several complicated noncommittals, 225 00:09:41,914 --> 00:09:44,259 so clearly my attitude is reasonable. 226 00:09:44,283 --> 00:09:46,528 We don't have room for a... 227 00:09:46,552 --> 00:09:48,696 skier exercise thing. 228 00:09:48,720 --> 00:09:51,733 I'm only putting it together so I can take a picture 229 00:09:51,757 --> 00:09:53,067 and sell it online. 230 00:09:53,091 --> 00:09:55,393 Why do you have it if you don't want it? 231 00:10:01,200 --> 00:10:03,987 My ex sent it. 232 00:10:05,003 --> 00:10:06,848 "Ex"? 233 00:10:06,872 --> 00:10:08,700 Husband. 234 00:10:09,808 --> 00:10:11,686 I left this thing in the attic 235 00:10:11,710 --> 00:10:13,922 until I got settled somewhere with enough space. 236 00:10:13,946 --> 00:10:15,723 And okay, that was 10 years ago, 237 00:10:15,747 --> 00:10:17,392 but it's not like it was in his way. 238 00:10:21,153 --> 00:10:25,433 We got married, not for long, right out of high school. 239 00:10:25,457 --> 00:10:27,135 Literally the boy next door. 240 00:10:27,159 --> 00:10:29,237 We grew up together. People expected it. 241 00:10:29,261 --> 00:10:32,474 It... was a big mistake. 242 00:10:32,498 --> 00:10:34,542 We both realized it pretty quickly. 243 00:10:39,304 --> 00:10:41,483 Why would you even want to live forever? 244 00:10:41,507 --> 00:10:42,851 You'd be bored out of your mind. 245 00:10:43,976 --> 00:10:45,320 The person I am now 246 00:10:45,344 --> 00:10:49,700 is miles away from the person I was at 14. 247 00:10:50,082 --> 00:10:52,578 I only get more distant every year. 248 00:10:53,305 --> 00:10:56,790 You learn to understand, 249 00:10:57,655 --> 00:11:00,669 love books that you once hated, 250 00:11:01,460 --> 00:11:04,305 sometimes people you once hated. 251 00:11:04,330 --> 00:11:09,078 Music that you didn't get the point of becomes magical. 252 00:11:09,201 --> 00:11:11,052 And a thousand new doors will open. 253 00:11:11,083 --> 00:11:13,182 I look forward to the adventure. 254 00:11:13,672 --> 00:11:14,885 Ow. 255 00:11:14,909 --> 00:11:17,842 Sorry. Adventure's not always gonna be fun. 256 00:11:19,057 --> 00:11:22,603 I figure it takes 40 or 50 years 257 00:11:22,628 --> 00:11:25,140 just to get over the things your parents did. 258 00:11:25,165 --> 00:11:26,876 If only we lived long enough, 259 00:11:26,901 --> 00:11:30,881 the human race might finally have a chance to grow up. 260 00:11:37,247 --> 00:11:39,792 What size shoes do you wear? 261 00:11:39,817 --> 00:11:41,376 7 1/2. 262 00:11:42,387 --> 00:11:44,499 "Dr. Allen's Walking On Clouds Inserts." 263 00:11:44,524 --> 00:11:46,935 Putting "doctor" in the name is always good marketing strategy. 264 00:11:46,960 --> 00:11:49,639 They're designed to reduce inflammation 265 00:11:49,664 --> 00:11:51,776 that could lead to plantar fasciitis, 266 00:11:51,801 --> 00:11:54,613 calluses, arthritis, and they feel damn good. 267 00:11:54,638 --> 00:11:56,482 Does this have anything to do with our patient's 268 00:11:56,507 --> 00:11:57,718 venture capitalist husband? 269 00:11:57,743 --> 00:11:59,254 I need testimonials. 270 00:11:59,279 --> 00:12:00,746 Labs and Path for Hannah Palmer. 271 00:12:04,024 --> 00:12:06,936 Aren't we all busy enough learning how to be surgeons? 272 00:12:06,960 --> 00:12:09,561 Do you really want to divide your focus onto something trivial? 273 00:12:14,501 --> 00:12:17,736 Because wanting to make money taints the purity of medicine? 274 00:12:19,606 --> 00:12:21,284 I have five brothers. 275 00:12:21,308 --> 00:12:23,686 I've been taking care of people my whole life. 276 00:12:23,710 --> 00:12:27,223 Someone got hurt, they came to me to patch them up. 277 00:12:27,247 --> 00:12:30,526 I became a doctor so I could get paid for it, 278 00:12:30,550 --> 00:12:33,729 but also because I'm good at taking care of people. 279 00:12:33,753 --> 00:12:36,065 It's possible to do something for more than one reason. 280 00:12:47,634 --> 00:12:49,111 The news is bad. 281 00:12:58,171 --> 00:13:01,483 There's an abnormally healthy population 282 00:13:01,508 --> 00:13:04,554 of hematopoietic progenitor stem cells. 283 00:13:04,579 --> 00:13:05,690 He did it? 284 00:13:05,715 --> 00:13:06,925 It's significant. 285 00:13:06,950 --> 00:13:09,929 He's succeeded in optimizing enough telomerase activity 286 00:13:09,954 --> 00:13:12,433 to potentially add 10 years to his natural life. 287 00:13:12,458 --> 00:13:14,936 Well, assuming it doesn't subtract about 50. 288 00:13:14,961 --> 00:13:16,539 There's already an autoimmune reaction 289 00:13:16,564 --> 00:13:17,774 that mimics Hirschsprung's. 290 00:13:17,799 --> 00:13:19,121 Who knows what else he did? 291 00:13:19,146 --> 00:13:21,664 What if this is the opposite of an auto-immune condition? 292 00:13:21,689 --> 00:13:22,924 What if he's done something 293 00:13:22,949 --> 00:13:24,756 that lowers his resistance to infection? 294 00:13:24,781 --> 00:13:27,126 Then we'd be seeing more opportunistic infections 295 00:13:27,151 --> 00:13:28,657 of the lungs and skin. 296 00:13:28,681 --> 00:13:30,392 If you lived another 1,000 years, 297 00:13:30,416 --> 00:13:32,628 would you be with the same person at the end 298 00:13:32,652 --> 00:13:34,029 as at the beginning? 299 00:13:34,053 --> 00:13:35,287 - No. - No. 300 00:13:36,389 --> 00:13:37,933 No, if you assume monogamy. 301 00:13:37,957 --> 00:13:39,935 I mean, that puts too much strain on a relationship. 302 00:13:39,959 --> 00:13:42,004 Is one person supposed to be everything to another, 303 00:13:42,028 --> 00:13:43,839 all the time, for 1,000 years? 304 00:13:43,863 --> 00:13:47,546 Apparently Jesus agrees. On monogamy. 305 00:13:47,570 --> 00:13:49,978 He said that, in Heaven, there'll be no more marriages. 306 00:13:50,002 --> 00:13:53,415 I guess humans can't sustain a relationship that long. 307 00:13:53,439 --> 00:13:54,816 You read the New Testament, too? 308 00:13:54,840 --> 00:13:57,319 And the Qur'an. And other things. 309 00:13:57,343 --> 00:13:58,720 It's like you're a stalker. 310 00:13:58,744 --> 00:14:01,323 It's like you and God had an acrimonious divorce. 311 00:14:01,347 --> 00:14:04,783 What if he caused neurofibromatosis? 312 00:14:04,807 --> 00:14:07,229 Microscopic tumors forming on the nerve sheath? 313 00:14:07,253 --> 00:14:08,764 Mm. Possible, but there'd have been 314 00:14:08,788 --> 00:14:10,132 some evidence of Schwann cell growth 315 00:14:10,156 --> 00:14:11,262 around his colon. 316 00:14:11,286 --> 00:14:14,159 Would you still love your wife in 1,000 years? 317 00:14:15,995 --> 00:14:18,073 You have three answers. That should be enough. 318 00:14:18,097 --> 00:14:20,409 Park's marriage failed in far less time, 319 00:14:20,433 --> 00:14:22,010 and Enrique doesn't even try. 320 00:14:22,034 --> 00:14:23,645 Asher is an... 321 00:14:23,669 --> 00:14:25,113 unknown quantity. 322 00:14:25,137 --> 00:14:26,439 You're committed. 323 00:14:26,463 --> 00:14:28,106 You've made promises. 324 00:14:30,509 --> 00:14:32,554 I've made promises based on 325 00:14:32,578 --> 00:14:35,634 an understood human life-span, Murphy. 326 00:14:36,415 --> 00:14:39,494 Most likely diagnosis is autoimmune polyneuropathy. 327 00:14:39,518 --> 00:14:41,196 It damaged the enteral ganglion nerve 328 00:14:41,220 --> 00:14:42,511 and led to the perforations. 329 00:14:42,545 --> 00:14:44,893 Start him on steroids and immunosuppressants. 330 00:14:45,356 --> 00:14:46,734 Dr. Andrews. 331 00:14:46,759 --> 00:14:48,637 So, you wouldn't have gotten married 332 00:14:48,662 --> 00:14:50,439 if you thought it would be forever. 333 00:14:50,464 --> 00:14:53,210 You expect all relationships to fail over time. 334 00:14:53,235 --> 00:14:55,002 It's just a question of how long? 335 00:14:56,895 --> 00:14:58,615 I love her now. 336 00:14:59,138 --> 00:15:02,661 I intend to love her as long as I live. 337 00:15:03,516 --> 00:15:08,263 But, eventually, everything breaks. 338 00:15:16,965 --> 00:15:18,275 I always go back to comfort reading 339 00:15:18,300 --> 00:15:19,450 when I'm in the hospital. 340 00:15:19,480 --> 00:15:21,315 Cozy mysteries in little English villages, 341 00:15:21,340 --> 00:15:23,807 where nothing bad happens to anyone we like. 342 00:15:25,624 --> 00:15:27,535 We've gotten your results back. 343 00:15:27,560 --> 00:15:28,604 When will your husband be... 344 00:15:28,629 --> 00:15:29,862 Is it cancer? 345 00:15:32,371 --> 00:15:33,538 Yes. 346 00:15:35,601 --> 00:15:37,320 Thyroid carcinoma. 347 00:15:38,089 --> 00:15:39,967 We're gonna do a complete imaging series 348 00:15:39,992 --> 00:15:41,170 to pinpoint just how advanced... 349 00:15:41,195 --> 00:15:42,617 Treatment? 350 00:15:43,229 --> 00:15:46,541 Surgery to remove some or all of your thyroid 351 00:15:46,566 --> 00:15:48,945 is usually the first line of defense. 352 00:15:48,970 --> 00:15:51,548 Sometimes, we can wait, but given the hematoma 353 00:15:51,573 --> 00:15:55,720 was probably caused by the tumor invading nearby vasculatures, 354 00:15:55,745 --> 00:15:58,157 we should probably do it in the next few days. 355 00:15:58,182 --> 00:16:01,428 Later, there'll be radioactive iodine treatment... 356 00:16:03,122 --> 00:16:04,466 Panic attack? 357 00:16:10,242 --> 00:16:11,552 Her trachea's deviated to the right. 358 00:16:11,577 --> 00:16:13,989 The tumor's compressing it. We're doing surgery now. 359 00:16:26,603 --> 00:16:28,181 What happened? The nurse just said "surgery." 360 00:16:28,205 --> 00:16:29,804 Was it the hematoma? 361 00:16:30,887 --> 00:16:32,288 It's more serious. 362 00:16:33,977 --> 00:16:36,489 I-It's not cancer... 363 00:16:36,513 --> 00:16:38,158 again. 364 00:16:38,182 --> 00:16:40,356 Thyroid carcinoma. 365 00:16:40,984 --> 00:16:43,930 We've removed her thyroid. She's doing well. 366 00:16:43,954 --> 00:16:45,732 We're looking into potential causes... 367 00:16:45,756 --> 00:16:47,567 Genetic, environmental. 368 00:16:47,591 --> 00:16:51,701 There may be a deeper issue that we can find and address. 369 00:17:02,005 --> 00:17:03,713 I can't do this. 370 00:17:05,676 --> 00:17:07,717 You've done it before. 371 00:17:08,412 --> 00:17:10,136 You'll do it this time. 372 00:17:15,853 --> 00:17:17,602 Do you know what it's like... 373 00:17:18,489 --> 00:17:20,100 to wake up every morning and know your wife 374 00:17:20,124 --> 00:17:21,772 might not be here next year? 375 00:17:23,727 --> 00:17:26,873 All those treatments... 376 00:17:26,897 --> 00:17:30,343 they all... they all have this little tag attached to them 377 00:17:30,367 --> 00:17:33,780 that says, "Because she might die." 378 00:17:33,804 --> 00:17:37,383 And you see them put those gloves on 379 00:17:37,407 --> 00:17:38,618 before they hook up the chemo. 380 00:17:38,642 --> 00:17:40,082 You know why they do that. 381 00:17:41,512 --> 00:17:43,379 It's because it's poison. 382 00:17:45,649 --> 00:17:47,340 And you sit there... 383 00:17:48,485 --> 00:17:52,011 and you watch them shove poison into the person you love. 384 00:17:52,322 --> 00:17:53,930 And why? 385 00:17:55,325 --> 00:17:57,627 Because she might die. 386 00:17:59,997 --> 00:18:02,698 We're killing her because she might die. 387 00:18:07,437 --> 00:18:08,715 Go for a run. 388 00:18:09,111 --> 00:18:11,072 Go punch a wall. 389 00:18:11,475 --> 00:18:13,016 You need to release some endorphins. 390 00:18:13,040 --> 00:18:15,088 My release is my job. 391 00:18:15,112 --> 00:18:16,823 That's why I love it. 392 00:18:16,847 --> 00:18:19,692 My work requires total focus. 393 00:18:19,716 --> 00:18:20,994 And every minute I'm working 394 00:18:21,018 --> 00:18:23,292 is a minute I'm not thinking about... 395 00:18:23,887 --> 00:18:25,021 losing her. 396 00:18:30,625 --> 00:18:32,071 I have to go. 397 00:18:37,750 --> 00:18:40,961 Your pain and weakness are consistent with polyneuropathy, 398 00:18:40,985 --> 00:18:43,716 treatable with steroids and immunosuppressants. 399 00:18:43,740 --> 00:18:46,943 If you live 1,000 years, will you still love Sophie? 400 00:18:49,398 --> 00:18:50,542 Yes. 401 00:18:50,567 --> 00:18:52,378 How can you be sure? 402 00:18:52,403 --> 00:18:55,049 People change. You expect to change. 403 00:18:55,408 --> 00:18:58,498 Sophie and I will change together. 404 00:18:58,522 --> 00:18:59,732 We'll go through the same adventures 405 00:18:59,756 --> 00:19:00,834 and learn the same lessons. 406 00:19:00,858 --> 00:19:03,131 What if you go through the same adventures 407 00:19:03,160 --> 00:19:05,038 and learn different lessons? 408 00:19:05,062 --> 00:19:08,107 Even if we did, whoever, whatever we become, 409 00:19:08,131 --> 00:19:09,809 Sophie will always be beautiful. 410 00:19:09,833 --> 00:19:12,385 I mean, she could turn into a machine or a set of pixels 411 00:19:12,409 --> 00:19:15,248 or a giant purple flower, and she'll still be beautiful, 412 00:19:15,272 --> 00:19:18,474 because it's part of her essential nature. 413 00:19:21,525 --> 00:19:23,936 But if you don't know how you'll change, 414 00:19:23,961 --> 00:19:25,773 you don't know how you'll change. 415 00:19:25,798 --> 00:19:27,231 Shaun. 416 00:19:28,444 --> 00:19:29,822 We'll let you get some rest. 417 00:19:29,847 --> 00:19:31,798 The steroids should make you feel a lot better. 418 00:19:38,128 --> 00:19:42,413 Why didn't you ever mention you had an ex-husband? 419 00:19:43,226 --> 00:19:47,239 Shaun, I've barely thought about him in years. 420 00:19:47,264 --> 00:19:51,244 I didn't mention him because he's not important. 421 00:19:51,269 --> 00:19:54,248 I know. That's the problem. 422 00:19:54,337 --> 00:19:57,383 At one time, you felt he was important enough to your life 423 00:19:57,408 --> 00:20:01,088 to marry him, and now you barely think of him. 424 00:20:01,113 --> 00:20:04,759 You make long-term plans, you have expectations, 425 00:20:04,784 --> 00:20:06,495 and then something happens to you, 426 00:20:06,520 --> 00:20:09,357 and suddenly you're a different person. 427 00:20:10,894 --> 00:20:15,279 I know you don't like change, but it's not all bad. 428 00:20:15,978 --> 00:20:20,359 After all, you are working to change yourself all the time. 429 00:20:20,384 --> 00:20:26,499 I'm working to be a better surgeon, a better boyfriend, 430 00:20:26,524 --> 00:20:28,789 better at the things I've chosen, 431 00:20:28,817 --> 00:20:30,211 but this... 432 00:20:30,679 --> 00:20:32,224 other change... It's unpredictable. 433 00:20:32,249 --> 00:20:33,259 You don't choose it. 434 00:20:33,284 --> 00:20:35,007 It just comes at you. 435 00:20:35,719 --> 00:20:38,105 Oh, it's like hurricanes before 1873, 436 00:20:38,141 --> 00:20:40,201 when the Army Signal Corps first put up flags 437 00:20:40,238 --> 00:20:42,101 to warn people storms were coming. 438 00:20:42,125 --> 00:20:44,837 Before that, houses were flattened, lives destroyed, 439 00:20:44,861 --> 00:20:46,996 and there was no way to see it was heading for you. 440 00:20:47,020 --> 00:20:48,234 Shaun. 441 00:20:49,245 --> 00:20:52,991 Our relationship will not end in natural disaster. 442 00:20:53,016 --> 00:20:54,560 It did begin in one. 443 00:20:56,922 --> 00:21:00,034 I'm going to look in on my patient. 444 00:21:00,491 --> 00:21:02,221 Okay. 445 00:21:08,554 --> 00:21:12,100 Blood and saliva will tell us if there's a genetic cause, 446 00:21:12,124 --> 00:21:13,936 and the samples we take from your house 447 00:21:13,960 --> 00:21:15,961 will tell us if there's something environmental. 448 00:21:17,897 --> 00:21:20,720 I know it's s-stupid. 449 00:21:21,500 --> 00:21:24,079 I've almost felt guilty for my cancer, 450 00:21:24,103 --> 00:21:28,506 like I arbitrarily decided to be sick and burdensome. 451 00:21:30,977 --> 00:21:32,454 Do the people you're close to 452 00:21:32,478 --> 00:21:35,290 ever act like you're a burden to them? 453 00:21:35,314 --> 00:21:36,481 You mean Alan. 454 00:21:38,784 --> 00:21:40,696 He's scared. 455 00:21:40,720 --> 00:21:45,033 He takes the exit he's got and he turns to his work. 456 00:21:45,057 --> 00:21:46,868 You're okay with that? 457 00:21:54,433 --> 00:21:56,845 I accept this compromise. 458 00:21:56,869 --> 00:21:59,149 That's not the hard part. The hard part is... 459 00:22:00,039 --> 00:22:01,635 not knowing. 460 00:22:03,083 --> 00:22:06,599 Each new thing that happens, I worry, "Is this it? 461 00:22:07,880 --> 00:22:09,769 Is this where I lose him? 462 00:22:10,976 --> 00:22:12,854 Is this where he breaks?" 463 00:22:19,820 --> 00:22:22,332 So, this is boiled coffee. 464 00:22:22,357 --> 00:22:24,101 Some people call it "Turkish coffee," 465 00:22:24,263 --> 00:22:27,202 or "Greek coffee," or "Egyptian coffee"... 466 00:22:27,252 --> 00:22:28,502 Because we need to take ownership 467 00:22:28,541 --> 00:22:30,105 and put things in categories. 468 00:22:30,135 --> 00:22:31,457 Yeah. 469 00:22:31,910 --> 00:22:33,454 You actually live in this thing, 470 00:22:33,479 --> 00:22:35,691 in the hospital parking garage? 471 00:22:35,716 --> 00:22:36,893 Why not? 472 00:22:36,918 --> 00:22:38,162 Convenient for work. 473 00:22:38,187 --> 00:22:40,632 When I want to spend a few days off the beaten track, 474 00:22:40,657 --> 00:22:42,384 it's convenient for that, too. 475 00:22:42,882 --> 00:22:45,627 Ooh. I'm gonna get three sips in this. 476 00:22:45,652 --> 00:22:47,653 But three really great sips. 477 00:22:49,395 --> 00:22:51,340 That's how I try to live my life... 478 00:22:51,365 --> 00:22:55,601 Try to appreciate, savor, not pass by. 479 00:22:58,644 --> 00:23:00,694 Is that what the polyamory is about? 480 00:23:01,874 --> 00:23:04,686 Does it really work, or is it one of those theories about life 481 00:23:04,711 --> 00:23:06,522 that people regret later? 482 00:23:06,547 --> 00:23:07,724 No regrets so far. 483 00:23:07,749 --> 00:23:09,327 Mm-hmm. No, I guess not. 484 00:23:09,352 --> 00:23:11,789 Not while you're young and having fun. 485 00:23:12,666 --> 00:23:13,976 It is fun, 486 00:23:14,001 --> 00:23:15,779 but not for the reasons that you're thinking. 487 00:23:15,804 --> 00:23:17,336 It isn't about sex. 488 00:23:17,991 --> 00:23:20,903 It's about commitment, emotional connection. 489 00:23:20,928 --> 00:23:23,273 The joy I'm sure you get out of a relationship, 490 00:23:23,298 --> 00:23:24,275 I get a little more. 491 00:23:24,300 --> 00:23:26,412 Also, I have to give a little more. 492 00:23:26,532 --> 00:23:28,264 But that's meaningful, too. 493 00:23:29,295 --> 00:23:30,891 Hmm. 494 00:23:31,737 --> 00:23:33,298 Do you mind if I ask you something, 495 00:23:33,366 --> 00:23:35,240 since we're getting personal? 496 00:23:39,005 --> 00:23:40,482 Sure. 497 00:23:40,806 --> 00:23:43,241 What's your favorite misheard song lyric? 498 00:23:51,577 --> 00:23:53,010 This is nice. 499 00:23:55,000 --> 00:23:57,084 I'm glad it's not a date. 500 00:23:57,490 --> 00:23:59,000 Me, too. 501 00:23:59,025 --> 00:24:00,793 I don't believe in those categories. 502 00:24:05,244 --> 00:24:07,856 He reported widespread bilateral pain, 503 00:24:07,881 --> 00:24:08,858 then he keeled over. 504 00:24:08,883 --> 00:24:10,227 B.P. dropped to 80 over palp. 505 00:24:10,252 --> 00:24:11,363 I'll order a vasopressor. 506 00:24:11,388 --> 00:24:12,799 - Already did. - Good. 507 00:24:12,824 --> 00:24:16,737 We need an EKG, CBC, and chest images, and a new diagnosis. 508 00:24:16,762 --> 00:24:19,541 Whatever he caused with CRISPR, it's not just neuropathy. 509 00:24:19,566 --> 00:24:21,510 Something else is killing him. 510 00:24:29,067 --> 00:24:30,721 What if he's caused something that mimics 511 00:24:30,761 --> 00:24:32,797 carcinomatous autonomic neuropathy? 512 00:24:32,821 --> 00:24:35,196 It explains the B.P. and bowel issue. 513 00:24:35,434 --> 00:24:38,402 That doesn't explain the sensory issue that led to the frostbite. 514 00:24:41,594 --> 00:24:43,205 A connective tissue disorder? 515 00:24:43,229 --> 00:24:44,606 That would have shown up on the scans. 516 00:24:44,630 --> 00:24:46,144 His chest looks normal. 517 00:24:51,170 --> 00:24:53,782 Maybe we can't think of the answer because there is no answer. 518 00:24:53,806 --> 00:24:55,884 We keep trying to jam it into these categories we know, 519 00:24:55,908 --> 00:24:57,381 the diseases that we know. 520 00:24:57,405 --> 00:24:59,755 But this never existed before. 521 00:24:59,779 --> 00:25:01,723 He created a new combination of genetic code. 522 00:25:01,747 --> 00:25:03,592 That means a new combination of symptoms. 523 00:25:03,616 --> 00:25:05,827 So, we shouldn't be looking at what fits the picture, 524 00:25:05,851 --> 00:25:07,529 but at what's closest to the picture, 525 00:25:07,553 --> 00:25:09,397 so we can at least figure out a treatment. 526 00:25:09,421 --> 00:25:13,268 And what it's closest to is amyloidosis. 527 00:25:13,292 --> 00:25:15,904 This isn't an autoimmune neuropathy, 528 00:25:15,928 --> 00:25:18,306 so the nerves must be under attack by something else. 529 00:25:18,330 --> 00:25:20,408 Something like amyloid disease could leave deposits 530 00:25:20,432 --> 00:25:23,145 along the nerves, causing the symptoms we've seen. 531 00:25:23,169 --> 00:25:25,080 Where do we look for those deposits? 532 00:25:25,104 --> 00:25:27,115 The spleen. 533 00:25:33,212 --> 00:25:34,756 Drink all 8 ounces. 534 00:25:35,656 --> 00:25:37,826 We talked. We had a few laughs. 535 00:25:37,850 --> 00:25:39,661 Well, sounds date-y to me. 536 00:25:40,753 --> 00:25:42,497 I don't think Enrique's a player. 537 00:25:42,521 --> 00:25:44,032 No, he's kind of the opposite of a player. 538 00:25:44,056 --> 00:25:46,535 With him, emotional connection is the point. 539 00:25:46,559 --> 00:25:48,770 He's trying to live some idealistic fantasy 540 00:25:48,794 --> 00:25:50,739 where everyone is nice and no one is jealous. 541 00:25:50,763 --> 00:25:52,307 I am so staying away. 542 00:25:52,331 --> 00:25:53,508 Well, of course. 543 00:25:53,532 --> 00:25:54,709 Once I heard "emotional connection," 544 00:25:54,733 --> 00:25:56,478 I knew the game was over. 545 00:25:56,502 --> 00:25:57,846 What does that mean? 546 00:25:57,870 --> 00:25:59,581 I'm against emotion? 547 00:25:59,605 --> 00:26:01,750 I'm not the one with "cold-hearted bitch" 548 00:26:01,774 --> 00:26:03,451 as my social media hashtag. 549 00:26:03,475 --> 00:26:04,653 She's an excellent doctor. 550 00:26:04,677 --> 00:26:06,121 Every time you've loved somebody, 551 00:26:06,145 --> 00:26:08,089 it's ended in disappointment or death... 552 00:26:08,113 --> 00:26:09,191 Sometimes both. 553 00:26:09,215 --> 00:26:10,525 It's like a reflex now. 554 00:26:10,549 --> 00:26:13,628 You just expect that everything ends badly, so why start? 555 00:26:13,652 --> 00:26:17,065 So, despite the many practical reasons not to go out 556 00:26:17,089 --> 00:26:19,067 with a first-year, this is all about me? 557 00:26:19,091 --> 00:26:21,602 Is that a diamond ring? 558 00:26:22,795 --> 00:26:23,972 I mean, it's pretty. 559 00:26:23,996 --> 00:26:25,607 Our patient caught her fiancé cheating. 560 00:26:25,631 --> 00:26:27,709 Big fight. He demanded the ring back. 561 00:26:27,733 --> 00:26:29,110 She swallowed it. 562 00:26:29,134 --> 00:26:30,312 I did. 563 00:26:30,336 --> 00:26:32,914 You don't even know if this is "going out," and that's the point. 564 00:26:32,938 --> 00:26:34,883 It doesn't matter what Enrique's offering. 565 00:26:34,907 --> 00:26:37,252 Whether it's friendship or romance, you're not investing. 566 00:26:37,276 --> 00:26:38,486 You're risk-averse. 567 00:26:38,510 --> 00:26:39,654 Your portfolio right now 568 00:26:39,678 --> 00:26:41,723 is entirely in T-Bills and money market. 569 00:26:41,747 --> 00:26:42,991 I have no idea what that means. 570 00:26:43,015 --> 00:26:44,693 And it's too bad, because a guy that can make you laugh 571 00:26:44,717 --> 00:26:46,661 might be just what you need right now. 572 00:26:47,146 --> 00:26:49,064 It's progressed to your large intestine. 573 00:26:49,088 --> 00:26:51,466 Here's a plastic bag. Put it over the toilet seat. 574 00:26:51,490 --> 00:26:53,702 You'll have every opportunity to recover your property. 575 00:26:57,582 --> 00:27:00,349 Don't run away from a chance at love. 576 00:27:01,725 --> 00:27:03,644 It's a date... 577 00:27:04,303 --> 00:27:06,314 maybe. I don't know. 578 00:27:06,338 --> 00:27:07,505 Oh. 579 00:27:09,141 --> 00:27:11,052 Her house is full of T.C.E... 580 00:27:11,076 --> 00:27:12,287 A side effect from chip-making 581 00:27:12,311 --> 00:27:14,189 back in Silicon Valley's early days. 582 00:27:14,213 --> 00:27:16,157 So, they move away from their toxic home, 583 00:27:16,181 --> 00:27:17,626 and hopefully things get a little better. 584 00:27:17,650 --> 00:27:18,927 Probably not much. 585 00:27:18,951 --> 00:27:20,929 She also has a genetic predisposition. 586 00:27:20,953 --> 00:27:22,764 It's both? 587 00:27:22,788 --> 00:27:24,589 She shouldn't go outside in a rainstorm. 588 00:27:25,949 --> 00:27:27,969 How do you tell a woman that her third cancer 589 00:27:27,993 --> 00:27:29,794 likely won't be close to her last? 590 00:27:32,898 --> 00:27:35,466 Unfortunately, this is a teaching moment. 591 00:27:38,270 --> 00:27:40,849 Dr. Allen, after 12 hours on duty, 592 00:27:40,873 --> 00:27:43,551 I can report that your inserts came through. 593 00:27:43,575 --> 00:27:45,832 Check your e-mail. You'll find my testimonial. 594 00:27:46,892 --> 00:27:48,023 Claire. Olivia. 595 00:27:55,721 --> 00:27:58,657 And if you're right, what will you do? 596 00:27:58,958 --> 00:28:01,569 We'll treat the symptoms with targeted drug therapies. 597 00:28:01,593 --> 00:28:04,112 There really isn't a disease, as such, that we can address. 598 00:28:04,154 --> 00:28:05,530 Ow. 599 00:28:11,474 --> 00:28:12,518 The pain shifted? 600 00:28:12,542 --> 00:28:13,652 Yeah. 601 00:28:13,676 --> 00:28:14,853 Oh. 602 00:28:14,877 --> 00:28:16,155 Never mind about the ultrasound. 603 00:28:16,179 --> 00:28:17,556 It'll be easier to check for deposits 604 00:28:17,580 --> 00:28:18,624 after the organ's been removed. 605 00:28:18,648 --> 00:28:19,958 After it's... Yeah. 606 00:28:19,982 --> 00:28:21,817 His spleen's about to rupture. Call a transport team. 607 00:28:34,307 --> 00:28:37,352 It's called Li-Fraumeni Syndrome... LFS. 608 00:28:37,376 --> 00:28:39,087 An inherited predisposition 609 00:28:39,111 --> 00:28:41,823 to developing a wide range of cancers. 610 00:28:41,847 --> 00:28:43,792 Yes, there was a toxin in your environment 611 00:28:43,816 --> 00:28:45,460 that likely played a role in this, 612 00:28:45,484 --> 00:28:47,696 but there will be other triggers in the future. 613 00:28:48,512 --> 00:28:49,898 Your body is super sensitive 614 00:28:49,922 --> 00:28:52,590 and will respond with tumors for the rest of your life. 615 00:28:59,898 --> 00:29:02,610 I know that's a shock, 616 00:29:02,634 --> 00:29:05,113 but here's what you should know... 617 00:29:05,137 --> 00:29:08,806 Most cancers are treatable if found early enough. 618 00:29:12,144 --> 00:29:15,056 We know the most common associated with LFS, 619 00:29:15,080 --> 00:29:17,258 and we can do surveillance... 620 00:29:17,282 --> 00:29:20,752 Nip anything in the bud before it becomes a problem. 621 00:29:22,287 --> 00:29:26,534 It may not seem this way now, but this is good. 622 00:29:26,558 --> 00:29:28,570 We know what we're dealing with. 623 00:29:28,594 --> 00:29:31,606 We're warned, and we'll be ready. 624 00:29:39,371 --> 00:29:41,616 He won't be able to handle this. 625 00:29:46,345 --> 00:29:49,324 Liver, pancreas... Other organs look normal. 626 00:29:49,348 --> 00:29:50,658 Ah. 627 00:29:50,682 --> 00:29:53,762 But there are calcified lesions along these nerves. 628 00:29:53,786 --> 00:29:55,864 He's gonna be in pain like this for the rest of his life. 629 00:29:55,888 --> 00:29:59,167 No. There's a reasonable chance it'll get worse 630 00:29:59,191 --> 00:30:00,568 as time goes on. 631 00:30:00,592 --> 00:30:02,637 I need my sharp-blunt curved scissors. 632 00:30:02,661 --> 00:30:04,996 What if we used CRISPR to reverse CRISPR? 633 00:30:06,532 --> 00:30:09,377 Researchers have identified a protein in certain bacteria 634 00:30:09,401 --> 00:30:11,346 that inhibits CRISPR. 635 00:30:11,370 --> 00:30:13,748 What if we insert the DNA that makes that protein 636 00:30:13,772 --> 00:30:15,083 into our patient's genome? 637 00:30:15,107 --> 00:30:17,052 That would deactivate the CRISPR gene. 638 00:30:17,076 --> 00:30:18,420 So, CRISPR messed him up permanently, 639 00:30:18,444 --> 00:30:20,155 and you think we should do more of it? 640 00:30:20,179 --> 00:30:21,956 I don't know. Our patient is a risk-taker. 641 00:30:21,980 --> 00:30:23,625 We'd need a delivery mechanism. 642 00:30:23,649 --> 00:30:25,927 The code would have to be introduced through a virus... 643 00:30:25,951 --> 00:30:28,986 A virus that specifically targets nerves. 644 00:30:30,722 --> 00:30:32,400 Polio targets nerves. 645 00:30:32,424 --> 00:30:34,369 Because this isn't risky enough. 646 00:30:34,393 --> 00:30:35,837 Polio is such a dangerous virus 647 00:30:35,861 --> 00:30:38,273 because it's so good at penetrating the nervous system. 648 00:30:56,315 --> 00:30:57,659 Dr. Murphy? 649 00:31:01,720 --> 00:31:06,734 She's going to be this way... forever. 650 00:31:06,758 --> 00:31:09,737 She'll have good periods and bad periods. 651 00:31:09,761 --> 00:31:12,990 But she will always have to be on her guard. 652 00:31:13,465 --> 00:31:17,077 Is she always gonna have to be on guard against you, too? 653 00:31:17,775 --> 00:31:18,986 What does that mean? 654 00:31:19,011 --> 00:31:21,289 Chronic illness puts strain on relationships. 655 00:31:21,440 --> 00:31:25,120 Statistically, it is more often the man who can't handle it. 656 00:31:25,144 --> 00:31:27,422 Our marriage is none of your business. 657 00:31:27,446 --> 00:31:28,956 Her health is my business. 658 00:31:28,981 --> 00:31:31,032 And your behavior adds to her stress. 659 00:31:33,418 --> 00:31:37,699 You look at her, and you imagine she's gone, and that is hard. 660 00:31:37,723 --> 00:31:38,956 I get it. 661 00:31:41,026 --> 00:31:43,979 She thinks the same thing when she looks at you. 662 00:31:44,730 --> 00:31:47,350 I never complain to her. I know it's nobody's fault. 663 00:31:47,374 --> 00:31:50,311 You don't think she knows you have trouble with all this? 664 00:31:50,335 --> 00:31:52,780 Every time something new happens, 665 00:31:52,804 --> 00:31:55,617 she wonders, is this the straw 666 00:31:55,641 --> 00:31:58,243 that is gonna break your marriage? 667 00:31:59,083 --> 00:32:01,628 You've got her living in a constant state of uncertainty. 668 00:32:01,653 --> 00:32:04,541 That is practically the definition of stress. 669 00:32:05,834 --> 00:32:09,631 So, this is the "straighten up and fly right" lecture. 670 00:32:09,655 --> 00:32:10,788 No. 671 00:32:12,758 --> 00:32:14,718 I am... 672 00:32:15,561 --> 00:32:20,598 I'm telling you to consider how best to time your divorce. 673 00:32:21,967 --> 00:32:24,879 There are gonna be a lot of new issues dropping on Hannah, 674 00:32:24,903 --> 00:32:26,424 and if you're gonna end up leaving anyway, 675 00:32:26,465 --> 00:32:27,797 you should start planning now. 676 00:32:27,833 --> 00:32:29,123 I don't want to leave my wife. 677 00:32:29,148 --> 00:32:30,776 My best advice? 678 00:32:31,816 --> 00:32:35,572 Help her through this next round of treatment as best you can, 679 00:32:36,087 --> 00:32:37,949 and then get out. 680 00:32:38,877 --> 00:32:42,323 It's hard living with someone who needs so much. 681 00:32:42,348 --> 00:32:46,328 I know you feel there is a point where you have nothing left, 682 00:32:46,353 --> 00:32:48,126 where you're ready to break. 683 00:32:49,707 --> 00:32:54,745 Just... don't break when she needs you most. 684 00:32:55,954 --> 00:32:58,032 Get out before that happens. 685 00:33:19,871 --> 00:33:22,116 Reading an article that's five years old? 686 00:33:22,140 --> 00:33:24,953 Dr. Glassman was once involved in an experimental attempt 687 00:33:24,977 --> 00:33:27,922 to treat Parkinson's with CRISPR technology. 688 00:33:27,946 --> 00:33:29,023 It failed. 689 00:33:29,047 --> 00:33:30,892 So, it's both old and it didn't work? 690 00:33:30,916 --> 00:33:33,561 Dr. Glassman likes his failures to be informative. 691 00:33:33,585 --> 00:33:35,596 That's why his articles are longer. 692 00:33:35,620 --> 00:33:38,215 Do you worry about losing the people you love? 693 00:33:43,929 --> 00:33:46,674 Because we can't stop ourselves from changing, 694 00:33:46,698 --> 00:33:49,010 which means we might stop loving someone, 695 00:33:49,034 --> 00:33:50,545 or they might stop loving us. 696 00:33:50,569 --> 00:33:52,563 It is a very bad thing. 697 00:33:53,189 --> 00:33:54,615 It is. 698 00:33:57,676 --> 00:34:01,990 So, no one can ever feel... safe. 699 00:34:02,014 --> 00:34:05,983 How can you keep going if you never feel safe? 700 00:34:10,389 --> 00:34:13,157 Well, sometimes, not changing is just as dangerous. 701 00:34:16,028 --> 00:34:19,673 So, how do you know when to do what? 702 00:34:22,134 --> 00:34:24,379 If you find the answer to that, let me know. 703 00:34:30,842 --> 00:34:32,653 - I have it. - You do? 704 00:34:32,677 --> 00:34:35,590 Dr. Glassman used varicella zoster virus 705 00:34:35,614 --> 00:34:38,426 as the delivery mechanism, which didn't work. 706 00:34:38,450 --> 00:34:40,528 His first choice was herpes simplex, 707 00:34:40,552 --> 00:34:42,196 but the technology was not up 708 00:34:42,220 --> 00:34:43,998 to putting their DNA package into it. 709 00:34:44,470 --> 00:34:46,401 The technology has improved. 710 00:34:46,425 --> 00:34:47,792 It can be done. 711 00:34:54,099 --> 00:34:55,743 Using conventional treatments, 712 00:34:55,767 --> 00:34:57,412 there's nothing more we can do for you. 713 00:34:57,436 --> 00:35:00,304 The pain will be permanent, and it could get worse. 714 00:35:01,673 --> 00:35:05,553 Well, I've not been one to be limited by the conventional. 715 00:35:06,477 --> 00:35:08,407 We think we can reverse the CRISPR. 716 00:35:08,432 --> 00:35:11,459 You want to reverse what I did? My telomerase change? 717 00:35:11,484 --> 00:35:13,029 They want to stop your pain. 718 00:35:13,054 --> 00:35:14,965 Soph, it's temporary. 719 00:35:14,990 --> 00:35:16,327 What is it, 40 years? 720 00:35:16,365 --> 00:35:19,405 That's nothing. Our real lives are ahead of us. 721 00:35:19,430 --> 00:35:21,775 Hey, look, as long as this doesn't kill me, 722 00:35:21,800 --> 00:35:25,046 I've made the right choice, no matter how bad things get. 723 00:35:25,071 --> 00:35:26,115 No. 724 00:35:27,992 --> 00:35:32,529 I was willing to exercise for hours and fast, 725 00:35:32,553 --> 00:35:34,886 to give up all sugar and alcohol 726 00:35:34,913 --> 00:35:37,652 and do all the other things that we needed to do 727 00:35:37,676 --> 00:35:41,547 to get to a future that I knew might never come. 728 00:35:42,654 --> 00:35:46,427 But now, you're asking me to watch you suffer 729 00:35:46,832 --> 00:35:48,643 for the rest of your life. 730 00:35:57,462 --> 00:36:00,608 You're the one who embraces change. 731 00:36:01,773 --> 00:36:07,288 So, change to the person who can be happy with me... 732 00:36:07,606 --> 00:36:09,374 here and now. 733 00:36:18,150 --> 00:36:20,584 Doctors, would you mind waiting outside? 734 00:36:27,031 --> 00:36:29,470 Why did she want us to leave? 735 00:36:30,202 --> 00:36:32,147 I think she's delivering an ultimatum. 736 00:36:45,321 --> 00:36:46,932 Are you sure about this? 737 00:36:46,957 --> 00:36:49,669 It seems there's always something else 738 00:36:49,694 --> 00:36:51,295 that I have to give up. 739 00:36:54,019 --> 00:36:56,846 But this isn't like sugar or cigarettes. 740 00:36:56,870 --> 00:36:59,124 You won't get over this in a hurry. 741 00:36:59,570 --> 00:37:01,085 No. 742 00:37:01,860 --> 00:37:03,461 Not in 1,000 years. 743 00:37:13,338 --> 00:37:15,099 Are you gonna be okay? 744 00:37:15,360 --> 00:37:16,537 I'm fine. 745 00:37:16,562 --> 00:37:19,608 Alan's at work, but there should be a taxi waiting. 746 00:37:19,633 --> 00:37:22,345 I won't say goodbye, Dr. Browne, 747 00:37:22,370 --> 00:37:25,983 'cause I'll probably be seeing you again pretty soon. 748 00:37:28,745 --> 00:37:31,591 I sent your cab away. 749 00:37:31,616 --> 00:37:33,909 I'm sorry I wasn't here sooner. 750 00:37:34,239 --> 00:37:37,886 I had to present a proposal to my partners. 751 00:37:45,454 --> 00:37:47,199 I'm selling them my share of the business. 752 00:37:51,509 --> 00:37:53,921 Is... Is there something else you want to do? 753 00:37:55,914 --> 00:37:56,891 Yes. 754 00:37:56,915 --> 00:37:58,828 ♪ What you're doing here? ♪ 755 00:37:58,852 --> 00:38:00,751 I want to be your husband. 756 00:38:08,047 --> 00:38:11,529 I realized I was so... 757 00:38:11,585 --> 00:38:14,783 afraid of losing you in the future... 758 00:38:17,395 --> 00:38:18,772 I was losing you now. 759 00:38:46,720 --> 00:38:48,353 Sorry. 760 00:38:48,393 --> 00:38:51,368 I hear your VC contact decided to quit the business. 761 00:38:53,377 --> 00:38:54,988 He did the right thing. 762 00:39:00,011 --> 00:39:02,221 ♪ Baby, don't lie to me ♪ 763 00:39:02,245 --> 00:39:03,749 You know... 764 00:39:05,150 --> 00:39:07,862 my feet are killing me. 765 00:39:30,255 --> 00:39:33,335 I'm open. To being friends. 766 00:39:33,376 --> 00:39:34,522 That's great. 767 00:39:34,559 --> 00:39:37,282 I'm open, too, to wherever this goes. 768 00:39:38,030 --> 00:39:40,508 It's going to friendship. 769 00:39:40,985 --> 00:39:42,329 Understood. 770 00:39:42,354 --> 00:39:43,909 But life is about change, 771 00:39:43,934 --> 00:39:45,545 which means, one day, you might change your mind. 772 00:39:45,570 --> 00:39:48,116 And if you did, I'd be open to that, too. 773 00:39:48,141 --> 00:39:49,641 It's not gonna happen. 774 00:39:52,364 --> 00:39:53,441 Okay. 775 00:40:01,581 --> 00:40:02,817 _ 776 00:40:02,842 --> 00:40:04,842 _ 777 00:40:04,867 --> 00:40:06,867 _ 778 00:40:14,086 --> 00:40:16,365 First, there should be no soap involved. 779 00:40:16,390 --> 00:40:18,268 Also, we need to stay at one end of the shower, 780 00:40:18,293 --> 00:40:21,705 so we don't accidentally knock into the temperature control. 781 00:40:22,114 --> 00:40:24,125 What changed your mind? 782 00:40:24,343 --> 00:40:27,356 I've been thinking about change over time. 783 00:40:27,381 --> 00:40:29,259 I spoke with people and also graphed 784 00:40:29,284 --> 00:40:30,861 several possibilities for us, 785 00:40:30,886 --> 00:40:32,698 using time as the horizontal axis 786 00:40:32,723 --> 00:40:33,966 and change as the vertical. 787 00:40:33,991 --> 00:40:37,104 I realized that the problem isn't really change. 788 00:40:37,129 --> 00:40:41,276 It's whether two people change in the same direction. 789 00:40:41,301 --> 00:40:43,323 We want to keep our coordinates close to each other 790 00:40:43,348 --> 00:40:45,313 for the rest of our lives. 791 00:40:46,779 --> 00:40:48,591 We certainly do. 792 00:40:49,276 --> 00:40:52,128 But people sometimes do drift apart. 793 00:40:52,153 --> 00:40:53,231 Yes. 794 00:40:53,268 --> 00:40:55,634 You need a warning when you and your partner 795 00:40:55,659 --> 00:40:57,070 might be starting to veer off, 796 00:40:57,095 --> 00:40:58,772 so you can both change course a little. 797 00:40:58,797 --> 00:41:01,042 You don't want a surprise realization when it's too late. 798 00:41:01,067 --> 00:41:02,445 Surprises are awful. 799 00:41:02,470 --> 00:41:05,615 The U.S. Army Signal Corps used flags to warn of hurricanes. 800 00:41:05,640 --> 00:41:07,618 I brought us this. 801 00:41:08,293 --> 00:41:10,861 A cowbell? 802 00:41:10,886 --> 00:41:14,032 If you see us heading in different directions, 803 00:41:14,057 --> 00:41:15,301 you ring it. 804 00:41:15,327 --> 00:41:17,872 Do we really need a bell? Can't I just tell you? 805 00:41:19,066 --> 00:41:21,311 Oh! When you ring it, I'll pay attention. 806 00:41:21,336 --> 00:41:22,847 I really hate the sound. 807 00:41:23,409 --> 00:41:25,879 Only in emergencies. 808 00:41:26,745 --> 00:41:30,066 I've already moved the shampoo bottles. 809 00:41:30,857 --> 00:41:32,001 What? 810 00:41:34,296 --> 00:41:35,740 Oh. 811 00:41:35,765 --> 00:41:37,510 You mean now? 812 00:41:40,939 --> 00:41:43,184 Don't worry about putting the bottles back. 813 00:41:43,209 --> 00:41:44,253 I'll do it later. 814 00:41:45,313 --> 00:41:47,310 I love you. 815 00:41:47,336 --> 00:41:50,195 It's no trouble. I remember where they all go.